Results 21 to 30 of about 142,808 (310)

Macrophage GSK3β-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy

Journal for ImmunoTherapy of Cancer, 2022
Background Glycogen synthase kinase 3β (GSK3β) was originally discovered to regulate glycogen synthesis and show a relationship to tumors. However, the biological functions of GSK3β in tumor-associated macrophages (TAMs) in cancers including ...
Li Liu, Jie Zhao, Jinyu Zhang, Guoqiang Sun, Yongxiang Xia, Xuehao Wang, Hanyuan Liu, Siqi Zhao, Zihao Zhang, Tian Huang, Xiangyi Kong, Weiwei Tang, Guangshun Sun, Hengsong Cao, Dawei Rong, Qinghua Ji   +15 more
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Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers

Molecular Therapy: Nucleic Acids, 2021
As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA modification processes have been reported, and they are widely present in every organism and overall RNA type.
Dawei Rong, Guangshun Sun, Fan Wu, Ye Cheng, Guoqiang Sun, Wei Jiang, Xiao Li, Yi Zhong, Liangliang Wu, Chuanyong Zhang, Weiwei Tang, Xuehao Wang   +11 more
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Impact of Retroperitoneoscopic Living Donor Nephrectomy at a Single Center [PDF]

, 2021
Laparoscopic living donor nephrectomy（LDN）has become a standard procedure, and transperitoneal LDN is now performed at many centers. Since 2001, we have been developing a retroperitoneoscopic living donor nephrectomy（RPLDN）technique that allows LDN to be
Inoue, Yasuyuki, Tokumoto, Tadahiko, Hyodo, Yoji, Osaka, Akiyoshi, Saito, Kazutaka, Setoguchi, Kiyoshi, Iwahata, Toshiyuki, Okada, Hiroshi   +7 more
core  

Long-term survival after anterior approach right hepatectomy combined with inferior vena cava thrombectomy using trans-diaphragmatic intrapericardial inferior vena cava occlusion: a case report and review of the literature

BMC Surgery, 2019
Background Presence of inferior vena cava tumor thrombosis (IVCTT) is an unfavorable factor to prognosis for patients with hepatocellular carcinoma (HCC). Case presentation Herein we report a case of HCC with IVC tumor thrombosis extending from the right
Yaodong Zhang, Zhengshan Wu, Ke Wang, Sheng Han, Changxian Li, Xiangcheng Li   +5 more
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PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells

Nature Communications, 2022
Members of the PRDI-BF1 and RIZ homology domain (PRDM) family have been involved in the regulation of several pathological conditions, including cancer.
Qing Li, Liren Zhang, Wenhua You, Jiali Xu, Jingjing Dai, Dongxu Hua, Ruizhi Zhang, Feifan Yao, Suiqing Zhou, Wei Huang, Yongjiu Dai, Yu Zhang, Tasiken Baheti, Xiaofeng Qian, Liyong Pu, Jing Xu, Yongxiang Xia, Chuanyong Zhang, Jinhai Tang, Xuehao Wang   +19 more
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Adult living donor liver imaging [PDF]

, 2016
Adult living donor liver transplantation (LDLT) is increasingly used for the treatment of end-stage liver disease. The three most commonly harvested grafts for LDLT are left lateral segment, left lobe, and right lobe grafts.
Westphalen, Antonio C, Yeh, Benjamin M, Larry Cai, Cai, Larry, Antonio C. Westphalen, John P. Roberts, Roberts, John P, Benjamin M. Yeh, Zhen J. Wang, Wang, Zhen J   +9 more
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Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function

Journal of Immunology Research, 2018
Transfer of splenocytes isolated from B6 mice into normal B6D2F1 mice induces acute graft-versus-host disease (aGVHD), resulting in the expansion of donor cytotoxic T lymphocytes that eliminate recipient B cells. The cytokine IL-22, secreted by Th1 cells,
Jianbo Wu, Jian Gu, Shun Zhou, Hao Lu, Yunjie Lu, Ling Lu, Xuehao Wang   +6 more
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Inhibition of Glycogen Synthase Kinase 3β Increases the Proportion and Suppressive Function of CD19+CD24hiCD27+ Breg Cells

Frontiers in Immunology, 2020
CD19+CD24hiCD27+ memory Breg cells exhibit decreased abundance in patients with chronic graft-versus-host disease (cGVHD) after liver transplantation and produce less IL-10 than those from patients without cGVHD and healthy donors.
Jinyang Li, Jinyang Li, Jinyang Li, Ji Gao, Ji Gao, Ji Gao, Haoming Zhou, Haoming Zhou, Haoming Zhou, Jinren Zhou, Jinren Zhou, Jinren Zhou, Zhenghua Deng, Zhenghua Deng, Zhenghua Deng, Yunjie Lu, Yunjie Lu, Yunjie Lu, Yunjie Lu, Jianhua Rao, Jianhua Rao, Jianhua Rao, Guwei Ji, Guwei Ji, Guwei Ji, Jian Gu, Jian Gu, Jian Gu, Xinxiang Yang, Xinxiang Yang, Xinxiang Yang, Yongxiang Xia, Yongxiang Xia, Yongxiang Xia, Xuehao Wang, Xuehao Wang, Xuehao Wang   +36 more
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PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Proteasome 26S subunit ATPase 2 (PSMC2) plays a pathogenic role in various cancers. However, its function and molecular mechanism in hepatocellular carcinoma (HCC) remain unknown.
Yiwei Liu, Yiwei Liu, Yiwei Liu, Hairong Chen, Xiangcheng Li, Xiangcheng Li, Xiangcheng Li, Feng Zhang, Feng Zhang, Feng Zhang, Lianbao Kong, Lianbao Kong, Lianbao Kong, Xuehao Wang, Xuehao Wang, Xuehao Wang, Jin Bai, Jin Bai, Xiaofeng Wu, Xiaofeng Wu, Xiaofeng Wu   +20 more
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HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

Signal Transduction and Targeted Therapy, 2021
N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia.
Qing Li, Yong Ni, Liren Zhang, Runqiu Jiang, Jing Xu, Hong Yang, Yuanchang Hu, Jiannan Qiu, Liyong Pu, Jinhai Tang, Xuehao Wang   +10 more
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