Results 101 to 110 of about 913,122 (305)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Investigating the effects of indoor lighting on measures of brain health in older adults: protocol for a cross-over randomized controlled trial

BMC Geriatrics
Background The worldwide number of adults aged 60 years and older is expected to double from 1 billion in 2019 to 2.1 billion by 2050. As the population lives longer, the rising incidence of chronic diseases, cognitive disorders, and behavioral health ...
Kevin A. Mazurek, Linhao Li, Robert J. Klein, Shengliang Rong, Aidan F. Mullan, David T. Jones, Erik K. St. Louis, Gregory A. Worrell, Christina Y. Chen   +8 more
doaj   +1 more source

Riverside Watershed Environmental Living Lab Systems [PDF]

, 2011
poster abstractThe project is named as Riverside Watershed Environmental Living Lab Systems (RWELLS). This project proposes extensive collaboration between community and university.
Koo, Dan
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Living lab approaches in rural healthcare: a scoping review

BMJ Open
Objective Living labs represent a user-centric approach to solving real-world challenges by encouraging active participation of external stakeholders in co-designing the research and innovation process.
Richard Fleet, Fatoumata Korinka Tounkara, Rose Joyal, Diane Singhroy   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Insights into maternal pertussis vaccination counselling: a qualitative study on perspectives and experiences among midwives and gynaecologists in the Netherlands

BMC Infectious Diseases
Background Healthcare professionals (HCPs) play a significant role in the decision-making process of pregnant women on maternal vaccinations. Whereas a high proportion of HCPs discuss maternal vaccinations with pregnant women, confidence in discussing ...
Veja Widdershoven, Eveline C.H. van Eerd, Marije Pfeyffer, Liesse M.L. Vanderhoven, Amanja Verhaegh-Haasnoot, Rianne P. Reijs, Christian J.P.A. Hoebe   +6 more
doaj   +1 more source

How can campus living labs thrive to reach sustainable solutions?

Cleaner Production Letters
Many Higher Education Institutions utilize living labs to address complex societal challenges and foster innovative and sustainable solutions on campus.
Annika Herth, Robert Verburg, Kornelis Blok   +2 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

URBAN LIVING LABS AS AN INNOVATIVE TOOL FOR ACHIEVING THE SUSTAINABLE DEVELOPMENT GOALS? EVIDENCE FROM POLAND

Central European Journal of Geography and Sustainable Development
The aim of the article is to analyse the activities of Urban Living Labs (ULL) in Poland from the perspective of supporting the realization of sustainable development goals at the local level. The article is based on an analysis of Internet materials (1,
Dagmara Helena Brzeziecka, Bartosz Piziak, Karolina Thel   +2 more
doaj   +1 more source