Results 91 to 100 of about 53,126,315 (234)

Induction of clnR is specific to LL-37-like cathelicidins.

, 2018
Induction of clnR is specific to LL-37-like cathelicidins.
Adrianne N. Edwards (5646344), Kevin O. Childress (5646347), Joshua B. Jones (5646350), Emily C. Woods (5646341), Shonna M. McBride (57435)   +4 more
core   +1 more source

Descriptor‐Informed Screening of Interface‐Active Molecules for Efficient Magnesium Metal Anodes

Advanced Materials, EarlyView.
A descriptor‐informed molecular screening strategy identifies 4‐bromo‐N, N‐dimethylaniline (BrNNA) as an interface‐active electrolyte component that enables fast Mg stripping/plating in Mg(TFSI)2‐based electrolytes. By simultaneously regulating Mg2+ solvation and interphase formation, the BrNNA‐containing electrolyte delivers activation‐free Mg ...
Hao Xu, Yue Li, Tian Xie, Arafat Hossain Khan, Fengzhan Sun, Zhao Li, Lingyue Liu, Zhaohui Yang, Xinlong Xie, Huayu Qiu, Quanquan Guo, Tian Sun, Xingyuan Chu, Jingwei Du, Jianxin Zou, Xinliang Feng, Minghao Yu   +16 more
wiley   +1 more source

Activation of Eosinophils Interacting with Bronchial Epithelial Cells by Antimicrobial Peptide LL-37: Implications in Allergic Asthma

Scientific Reports, 2017
The role of antimicrobial peptide LL-37 in asthma exacerbation is unclear. Microbial infection, which is the most common inducer of asthma exacerbation, is accompanied by elevated LL-37.
Delong Jiao, Chun-Kwok Wong, Miranda Sin-Man Tsang, Ida Miu-Ting Chu, Dehua Liu, Jing Zhu, Man Chu, Christopher Wai-Kei Lam   +7 more
doaj   +1 more source

Apolipoprotein A-I attenuates LL-37-induced endothelial cell cytotoxicity

, 2017
The human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm functions, but LL-37 may also damage the host by triggering inflammation and exerting a cytotoxic effect, thereby reducing host cell viability.
Daniel Svensson, Nilsson, Bengt Olof, Jens O. Lagerstedt, Del Giudice, Rita, Rita Del Giudice, Svensson, Daniel, Lagerstedt, Jens O., Bengt-Olof Nilsson, Nilsson, Bengt Olof,, Svensson, Daniel,, Lagerstedt, Jens O.,, Lund University., Del Giudice, Rita,   +12 more
core   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

LL-37 Attenuates Sepsis-Induced Lung Injury by Alleviating Inflammatory Response and Epithelial Cell Oxidative Injury via ZBP1-Mediated Autophagy

Toxins
Background: Sepsis-induced acute lung injury (ALI) is a serious disease constituting a heavy burden on society due to high mortality and morbidity. Inflammation and oxidative stress constitute key pathological mechanisms in ALI caused by sepsis.
Hu Gao, Fajuan Tang, Bin Chen, Xihong Li
doaj   +1 more source

LL-37 has antiviral activity against RSV.

, 2013
a) Sequences of LL-37, three 22-mer peptides (representing the N-terminal, central core and C-terminal regions) and scrambled LL-37 peptide, b) HEp-2 or c) 16HBE14o- cells were infected with RSV (MOI = 0.005) and simultaneously treated with LL-37 or a ...
Tian Man (452500), Donald J. Davidson (341314), Jürgen Schwarze (84947), Annie Mackellar (341310), Brian J. McHugh (317010), Silke M. Currie (452499), Derek Macmillan (452501), Hongwei Wang (151141), Emily Gwyer Findlay (401583), Paul M. Fitch (452502)   +9 more
core   +1 more source

Blending With Insulating Polymers Enables Stable Anti‐Ambipolar Characteristics in n‐Type Organic Mixed‐Conductors for Heterogeneous Spiking Neurons

Advanced Materials, EarlyView.
A polymer blend of n‐type OMIEC P(gNDI‐gT2) with insulating PMMA yields mechanically stabilized, anti‐ambipolar organic electrochemical transistors (OECTs) with tunable ionic‐electronic transport. This blending allows low‐power, fast‐spiking heterogeneous Hodgkin–Huxley neurons, enabling biomimetic frequency deconvolution and reservoir computing, which
Zachary Laswick, Ariel Lifer, Catherine Beaumont, Liad Hayoun, Priscila Cavassin, Zeinab Hamid, Dilara Meli, William Dupont, Lincoln J. Lauhon, Iain McCulloch, Gitti L. Frey, Giovanni Maria Matrone, Jonathan Rivnay   +12 more
wiley   +1 more source

Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn’s disease, and clinical prognosis in inflammatory bowel disease

BMC Gastroenterology, 2017
Background Cathelicidin (LL-37) is an antimicrobial peptide known to be associated with various autoimmune diseases. We attempt to determine if cathelicidin can accurately reflect IBD disease activity.
Diana Hoang-Ngoc Tran, Jiani Wang, Christina Ha, Wendy Ho, S. Anjani Mattai, Angelos Oikonomopoulos, Guy Weiss, Precious Lacey, Michelle Cheng, Christine Shieh, Caroline C. Mussatto, Samantha Ho, Daniel Hommes, Hon Wai Koon   +13 more
doaj   +1 more source

LL-37-induced human osteoblast cytotoxicity and permeability occurs independently of cellular LL-37 uptake through clathrin-mediated endocytosis

, 2018
The host defense peptide LL-37 is cytotoxic for bacteria but it has also been reported to reduce host cell viability through an intracellular mechanism.
Nilsson, Bengt Olof, Anders, Emma, Nilsson, Bengt Olof,, Svensson, Daniel, Svensson, Daniel,, Daniel Svensson, Sara Dahl, Dahl, Sara,, Dahl, Sara, Anders, Emma,, Lund University., Emma Anders, Bengt-Olof Nilsson   +12 more
core   +1 more source