Salivary Cathelicidin (LL-37) in Children and Adolescents Living with HIV [PDF]
Biomedicine HubIntroduction: Human cathelicidin LL-37 is a salivary antimicrobial peptide (AMP) with broad-spectrum activity against oral diseases, but few studies have assessed its role in children and adolescents living with HIV (CALHIV).
Ana Lucia Seminario +8 more
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Antifungal Activity of Human Cathelicidin LL-37, a Membrane Disrupting Peptide, by Triggering Oxidative Stress and Cell Cycle Arrest in Candida auris [PDF]
Journal of Fungi, 2022 Candida auris, an evolving multidrug-resistant pathogenic yeast, is known for causing severe invasive infections associated with high mortality rates in hospitalized individuals. Distinct from other Candida species, C.
Irfan A. Rather +3 more
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Efficacy of Cathelicidin LL-37 in an MRSA Wound Infection Mouse Model [PDF]
Antibiotics, 2021 Background: LL-37 is the only human antimicrobial peptide that belongs to the cathelicidins. The aim of the study was to evaluate the efficacy of LL-37 in the management of MRSA-infected surgical wounds in mice. Methods: A wound on the back of adult male
Oriana Simonetti +13 more
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Epithelial-Immune Cell Crosstalk Determines the Activation of Immune Cells In Vitro by the Human Cathelicidin LL-37 at Low Physiological Concentrations [PDF]
Biomolecules, 2023 The only human cathelicidin, LL-37, is a host defense antimicrobial peptide with antimicrobial activities against protozoans, fungi, Gram(+) and Gram(−) bacteria, and enveloped viruses.
Ivan V. Bogdanov +5 more
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Colonic epithelial cathelicidin (LL‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate [PDF]
The Journal of Pathology: Clinical Research, 2021 Colorectal cancer (CRC) remains a leading cause of cancer mortality. Here, we define the colonic epithelial expression of cathelicidin (LL‐37) in CRC. Cathelicidin exerts pleotropic effects including anti‐microbial and immunoregulatory functions. Genetic
Ross J Porter +9 more
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Cathelicidin LL-37: A new important molecule in the pathophysiology of systemic lupus erythematosus [PDF]
Journal of Translational Autoimmunity, 2020 Cathelicidin LL-37 is an antimicrobial peptide that is synthesized by epithelial cells, neutrophils, or lymphocytes and act as an essential defense mechanism against bacterial, viral, or fungi infection of eukaryotic organisms.
Alejandro Moreno-Angarita +2 more
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Evaluation of the relationship between salivary levels of Streptococcus mutans, statherin, and cathelicidin LL-37 and early childhood caries [PDF]
BMC Oral HealthBackground Although caries is known to be influenced by diet and oral hygiene factors, susceptibility to the disease may be reduced by host factors, such as saliva antimicrobial peptides (AMPs).
Ceren Pamuk +8 more
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Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection [PDF]
Frontiers in Immunology, 2020 Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and ...
Víctor Casanova +9 more
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Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
Frontiers in Immunology, 2023 Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk.
Qing Zhang +6 more
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Frontiers in Bioscience-Landmark, 2021 Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived from its precursor protein hCAP18, which is an only cathelicidin in human.
Keqiang Chen +4 more
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