Results 21 to 30 of about 52,950,106 (199)

Cathelicidin LL-37 Ignites Primed NLRP3 Inflammasomes in Rosacea [PDF]

Journal of Investigative Dermatology, 2021
Microbes and commensal mites contribute to the development of inflammation and neurovascular dysregulation in rosacea. Cathelicidin family proteins are epithelial antimicrobial peptides expressed in higher-order mammals. In humans, mature LL-37 is cleaved from its precursor in response to microbial infection, UV light, and injury.
David O. Croitoru, Vincent Piguet
openaire   +2 more sources

The Role of Cathelicidin LL-37 in Cancer Development. [PDF]

Arch Immunol Ther Exp (Warsz), 2016
LL-37 is a C-terminal peptide proteolytically released from 18 kDa human cathelicidin protein (hCAP18). Chronic infections, inflammation, tissue injury and tissue regeneration are all linked with neoplastic growth, and involve LL-37 antibacterial and immunomodulatory functions.
Piktel E, Niemirowicz K, Wnorowska U, Wątek M, Wollny T, Głuszek K, Góźdź S, Levental I, Bucki R.   +8 more
europepmc   +5 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

The Roles of Cathelicidin LL-37 in Inflammatory Bowel Disease [PDF]

Inflammatory Bowel Diseases, 2016
Human cathelicidin LL-37, the only member of the cathelicidin family of host defense peptides expressed in humans, plays a crucial role in host defense against pathogen invasion, as well as in regulating the functions of anti-inflammation, antitumorigenesis, and tissue repair.
Lihua, Sun, Wensheng, Wang, Weidong, Xiao, Hua, Yang   +3 more
openaire   +2 more sources

Study of serum level of cathelicidin in patients with inflammatory bowel disease and its correlation to disease activity

Al-Azhar Assiut Medical Journal, 2020
Introduction Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn’s disease (CD). Genetic susceptibility together with environmental factors disturbs intestinal homeostasis, resulting in repeated and chronic inflammation with ...
Abeer A Mohamed, Amani K Mohamed, Radwa S Shahin, Fatma M El-Senosy   +3 more
doaj   +1 more source

Modulation of exogenous antibiotic activity by host cathelicidin LL‐37 [PDF]

APMIS, 2010
Leszczyńska K, Namiot A, Janmey PA, Bucki R. Modulation of exogenous antibiotic activity by host cathelicidin LL‐37. APMIS 2010; 118: 830–6.The increasing number of infections caused by drug‐resistant bacteria has spurred efforts to develop new therapeutic strategies. When applied locally, exogenous antibiotics work in an environment rich in endogenous
Katarzyna Leszczyńska, Andrzej Namiot, Janmey, Paul, Robert Bucki   +3 more
openaire   +2 more sources

Differential cathelicidin expression in duodenal and gastric biopsies from Tanzanian and German patients. [PDF]

, 2011
Epithelial surfaces such as the gastrointestinal mucosa depend on expression of antimicrobial peptides like cathelicidin for immune defence against pathogens. The mechanisms behind mucosal cathelicidin regulation are incompletely understood. Cathelicidin
Juergen Schauber, August Stich, Wolfgang Scheppach, Rogoll Dorothee, Koy K Mheta, Stich, August, Dorothee Rogoll, Schauber Juergen, Stich August, Scheppach, Wolfgang, Mheta Koy K., Schauber, Jürgen, Scheppach Wolfgang, Rogoll, Dorothee, Mheta, Koy K., Schauber, Juergen, Koy K. Mheta   +16 more
core   +1 more source

IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection

Gut Microbes, 2021
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory
Banglao Xu, Xianan Wu, Yi Gong, Ju Cao
doaj   +1 more source

An Unexplored Molecule in the Diagnosis of Allergic Rhinitis: LL-37

B-ENT, 2023
Objective: Cathelicidin (LL-37) is an innate immune endogenous peptide. Although its activity has been proven in many diseases in the literature, there is no information about the role of LL-37 in allergic rhinitis.
Erkan Yıldız, Selçuk Kuzu, Şahin Ulu, Orhan Kemal Kahveci   +3 more
doaj   +2 more sources

A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages

Frontiers in Immunology, 2021
BackgroundRosacea, a chronic inflammatory skin disorder etiologically associated with immune cells and the antibacterial peptide cathelicidin LL-37, can be effectively treated by oral carvedilol administration.ObjectiveTo investigate the molecular ...
Jiawen Zhang, Peiyu Jiang, Lei Sheng, Yunyi Liu, Yixuan Liu, Min Li, Meng Tao, Liang Hu, Xiaoyan Wang, Yanjing Yang, Yang Xu, Wentao Liu   +11 more
doaj   +1 more source