Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success [PDF]
Pharmaceutics, 2021 Amphiphilic antimicrobial polymers have attracted considerable interest as structural mimics of host defense peptides (HDPs) that provide a broad spectrum of activity and do not induce bacterial-drug resistance.
Hashem Etayash, Robert E. W. Hancock
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Regulation of Host Defense Peptide Synthesis by Polyphenols [PDF]
Antibiotics, 2023 The rise of antimicrobial resistance has created an urgent need for antibiotic-alternative strategies for disease control and prevention. Host defense peptides (HDPs), which have both antimicrobial and immunomodulatory properties, are an important ...
Isabel Tobin, Guolong Zhang
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Impacts of PEGylation and Glycosylation on the Biological Properties of Host Defense Peptide IDR1018 [PDF]
Pharmaceutics, 2023 The multifunctional properties of host defense peptides (HDPs) make them promising drug candidates to tackle bacterial infections and tissue inflammation.
Hashem Etayash +2 more
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Resistin, a Novel Host Defense Peptide of Innate Immunity [PDF]
Frontiers in Immunology, 2021 Resistin, a cysteine-rich protein, expressed in adipocytes, was initially proposed as a link between obesity and diabetes in mice. In humans, resistin is considered to be a pro-inflammatory molecule expressed in immune cells, which plays a regulatory ...
Yanran Li +9 more
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Host-Defense-Peptide-Mimicking β-Peptide Polymer Acting as a Dual-Modal Antibacterial Agent by Interfering Quorum Sensing and Killing Individual Bacteria Simultaneously [PDF]
Research, 2023 Host defense peptides (HDPs) are one of the potentially promising agents for infection diseases due to their broad spectrum and low resistance rate, but their clinical applications are limited by proteolytic instability, high-cost, and complicated ...
Wanlin Li +12 more
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MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide [PDF]
eLifeThe mitochondrial DNA (mtDNA) can trigger immune responses and directly entrap pathogens, but it is not known to encode active immune factors. The immune system is traditionally thought to be exclusively nuclear-encoded.
Michelle C Rice +13 more
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Reassessing the Host Defense Peptide Landscape [PDF]
Frontiers in Chemistry, 2019 Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicrobial peptides (
Evan F. Haney +2 more
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Modulation of the immune response by the host defense peptide IDR-1002 in chicken hepatic cell culture [PDF]
Scientific Reports, 2023 IDR-1002, a synthetic host defense peptide (HDP), appears to be a potential candidate for the treatment of bacterial infections and the consequent inflammatory response due to its potent immunomodulatory activity.
Csilla Sebők +7 more
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Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus Aspergillus fumigatus [PDF]
Microbiology SpectrumAspergillus fumigatus is the primary etiological agent of aspergillosis. Here, we show that the host defense peptide mimetic brilacidin (BRI) can potentiate ibrexafungerp (IBX) against clinical isolates of A. fumigatus.
Thaila Fernanda dos Reis +4 more
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Functions of Cationic Host Defense Peptides in Immunity
Pharmaceuticals, 2016 Cationic host defense peptides are a widely distributed family of immunomodulatory molecules with antimicrobial properties. The biological functions of these peptides include the ability to influence innate and adaptive immunity for efficient resolution ...
Mahadevappa Hemshekhar +2 more
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