Results 11 to 20 of about 2,814,854 (281)

Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps [PDF]

Biomolecules, 2020
In recent years, the number of new antimicrobial drugs launched on the market has decreased considerably even though there has been an increase in the number of resistant microbial strains.
Carlos José Correia Santana, Ana Carolina Martins Magalhães, César Augusto Prías-Márquez, Diego A. Falico, Agenor C. M. dos Santos Júnior, Beatriz D. Lima, Carlos André Ornelas Ricart, Denise Regina Bairros de Pilger, Rafaela Milan Bonotto, Carolina Borsoi Moraes, Lúcio H. Freitas-Júnior, Alice da Cunha Morales Álvares, Sonia Maria Freitas, Isabelle S. Luz, Osmindo Rodrigues Pires Jr., Wagner Fontes, Mariana S. Castro   +16 more
doaj   +3 more sources

Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria [PDF]

Frontiers in Immunology, 2017
Host-defense peptides play a fundamental role in the innate immune system by modulating inflammatory responses. Previously, it was shown that the thrombin derived host-defense peptide GKY25 inhibits LPS-induced responses of monocytes and macrophages in ...
Finja C. Hansen, Ann-Charlotte Strömdahl, Matthias Mörgelin, Artur Schmidtchen, Artur Schmidtchen, Artur Schmidtchen, Mariena J. A. van der Plas   +6 more
doaj   +3 more sources

TLR4-interacting SPA4 peptide improves host defense and alleviates tissue injury in a mouse model of Pseudomonas aeruginosa lung infection.

PLoS ONE, 2019
Interaction between surfactant protein-A (SP-A) and toll-like receptor (TLR)4 plays a critical role in host defense. In this work, we studied the host defense function of SPA4 peptide (amino acids GDFRYSDGTPVNYTNWYRGE), derived from the TLR4-interacting ...
Shanjana Awasthi, Bhupinder Singh, Vijay Ramani, Jun Xie, Stanley Kosanke   +4 more
doaj   +2 more sources

Exploring the impact of the host defense peptide Pap12-6 on immune response and epithelial integrity in chicken-derived ileal explant cultures [PDF]

Poultry Science
Due to the spread of antimicrobial resistance, there is an urgent need to search for novel antimicrobial agents. In poultry farming, animals are constantly exposed to enteral pathogens and are simultaneously required to maintain high production ...
Rege Anna Márton, Patrik Tráj, Máté Mackei, Csilla Sebők, Júlia Vörösházi, Ágnes Kemény, Evelin Kámán-Tóth, Dávid Géza Horváth, Viviána Molnár-Nagy, Zsuzsanna Neogrády, Gábor Mátis   +10 more
doaj   +2 more sources

The Antimicrobial and Host Defense Peptides of Drosophila melanogaster [PDF]

Annual Review of Microbiology
Drosophila fruit flies are a powerful model for studying innate immunity. In Drosophila , seven classical antimicrobial peptide (AMP) gene families were identified in the 1990s.
Lemaitre, Bruno, Bulet, Philippe, Hanson, Mark A., Westlake, Hannah E.   +3 more
core   +4 more sources

Editorial: Advances in the Immunology of Host Defense Peptide: Mechanisms and Applications of Antimicrobial Functions and Beyond [PDF]

Frontiers in Immunology, 2021
Thanh Kha Phan, Charles L. Bevins, Mark D. Hulett   +2 more
doaj   +2 more sources

Host Defense Peptide Piscidin and Yeast-Derived Glycolipid Exhibit Synergistic Antimicrobial Action through Concerted Interactions with Membranes [PDF]

JACS Au, 2023
Fei Liu, Alexander I. Greenwood, Yawei Xiong, Rebecca T. Miceli, Riqiang Fu, Kyle W. Anderson, Scott A. McCallum, Mihaela Mihailescu, Richard Gross, Myriam L. Cotten   +9 more
doaj   +2 more sources

Host Defense Peptides from Asian Frogs as Potential Clinical Therapies

Antibiotics, 2015
Host defense peptides (HDPs) are currently major focal points of medical research as infectious microbes are gaining resistance to existing drugs. They are effective against multi-drug resistant pathogens due to their unique primary target, biological ...
Vineeth T.V. Kumar, David Holthausen, Joshy Jacob, Sanil George   +3 more
doaj   +2 more sources

Oncolytic Activities of Host Defense Peptides [PDF]

International Journal of Molecular Sciences, 2011
Cancer continues to be a leading source of morbidity and mortality worldwide in spite of progress in oncolytic therapies. In addition, the incidence of cancers affecting the breast, kidney, prostate and skin among others continue to rise. Chemotherapeutic drugs are widely used in cancer treatment but have the serious drawback of nonspecific toxicity ...
Benna, Sammy al-, Shai, Yechiel (Prof.), Jacobsen, Frank (Dr. med.), Steinsträßer, Lars (Prof. Dr. med.)   +3 more
openaire   +3 more sources

Pap12-6: A host defense peptide with potent immunomodulatory activity in a chicken hepatic cell culture [PDF]

PLoS ONE
Rege Anna Márton, Csilla Sebők, Máté Mackei, Patrik Tráj, Júlia Vörösházi, Ágnes Kemény, Zsuzsanna Neogrády, Gábor Mátis   +7 more
doaj   +2 more sources