Results 41 to 50 of about 2,814,854 (281)

The Roles of Antimicrobial Peptides in Innate Host Defense [PDF]

Current Pharmaceutical Design, 2009
Antimicrobial peptides (AMPs) are multi-functional peptides whose fundamental biological role in vivo has been proposed to be the elimination of pathogenic microorganisms, including Gram-positive and -negative bacteria, fungi, and viruses. Genes encoding these peptides are expressed in a variety of cells in the host, including circulating phagocytic ...
Gill, Diamond, Nicholas, Beckloff, Aaron, Weinberg, Kevin O, Kisich   +3 more
openaire   +2 more sources

Defensins: A Double-Edged Sword in Host Immunity

Frontiers in Immunology, 2020
Defensins are a major family of host defense peptides expressed predominantly in neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted immunomodulatory functions have been extensively studied, cementing their role in ...
Dan Xu, Wuyuan Lu
doaj   +1 more source

Host Defense Peptides at the Ocular Surface: Roles in Health and Major Diseases, and Therapeutic Potentials

Frontiers in Medicine, 2022
Sight is arguably the most important sense in human. Being constantly exposed to the environmental stress, irritants and pathogens, the ocular surface – a specialized functional and anatomical unit composed of tear film, conjunctival and corneal ...
Darren Shu Jeng Ting, Darren Shu Jeng Ting, Darren Shu Jeng Ting, Imran Mohammed, Rajamani Lakshminarayanan, Roger W. Beuerman, Harminder S. Dua, Harminder S. Dua   +7 more
doaj   +1 more source

Antimicrobial peptides of buffalo and their role in host defenses [PDF]

Veterinary World, 2018
Antimicrobial peptides (AMPs) are highly conserved components of the innate immune system found among all classes of life. Buffalo (Bubalus bubalis), an important livestock for milk and meat production, is known to have a better resistance to many diseases as compared to cattle.
Khangembam Victoria Chanu, Dimpal Thakuria, Satish Kumar   +2 more
openaire   +3 more sources

Molecular Dynamics Simulations of the Host Defense Peptide Temporin L and Its Q3K Derivative: An Atomic Level View from Aggregation in Water to Bilayer Perturbation

Molecules, 2017
Temporin L (TempL) is a 13 residue Host Defense Peptide (HDP) isolated from the skin of frogs. It has a strong affinity for lipopolysaccharides (LPS), which is related to its high activity against Gram-negative bacteria and also to its strong tendency to
Andrea Farrotti, Paolo Conflitti, Saurabh Srivastava, Jimut Kanti Ghosh, Antonio Palleschi, Lorenzo Stella, Gianfranco Bocchinfuso   +6 more
doaj   +1 more source

Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection. [PDF]

PLoS ONE, 2017
Pseudomonas aeruginosa is a frequent cause of lung infections, particularly in chronic infections in cystic fibrosis patients. However, treatment is challenging due to P.
Kelli C Wuerth, Reza Falsafi, Robert E W Hancock   +2 more
doaj   +1 more source

Host Defense Peptides for Intracellular Bacterial Infections: Overcoming Translational Barriers Through Peptide Engineering and Nanotechnology-Based Drug Delivery Systems

Pharmaceutics
Intracellular bacterial infections represent a major therapeutic challenge due to the ability of pathogens to persist within host cells, evade host immune surveillance and exhibit reduced susceptibility to conventional antibiotics.
Aswathy R. Devan, Pradeesh Babu, Geetha B. Kumar, Bipin G. Nair, Agiesh Kumar Balakrishna Pillai, Aravind Madhavan   +5 more
doaj   +1 more source

The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria

Frontiers in Immunology, 2020
Host defense peptides, abundantly secreted by colonic epithelial cells and leukocytes, are proposed to be critical components of an innate immune response in the colon against enteropathogenic bacteria, including Shigella spp., Salmonella spp ...
Graham A. D. Blyth, Liam Connors, Cristina Fodor, Eduardo R. Cobo   +3 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag?TSG101 interaction

, 2008
The egress of HIV particles from virus-infected cells is accomplished by the recruitment of proteins that normally mediate host cell endocytic functions.
Gam, Jongsik, Cohen, Stanley N., Benkovic, Stephen J., Pans, Hui, Tavassoli, Ali, Lu, Quan   +5 more
core   +1 more source