Results 61 to 70 of about 2,814,854 (281)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The human host defense peptide LL-37 interacts with Neisseria meningitidis capsular polysaccharides and inhibits inflammatory mediators release. [PDF]

PLoS ONE, 2010
Capsular polysaccharides (CPS) are a major virulence factor in meningococcal infections and form the basis for serogroup designation and protective vaccines.
Susu M Zughaier, Pavel Svoboda, Jan Pohl, David S Stephens, William M Shafer   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Toward the Discovery of Host-Defense Peptides in Plants [PDF]

Frontiers in Immunology, 2020
Defense peptides protect multicellular eukaryotes from infections. In biomedical sciences, a dominant conceptual framework refers to defense peptides as host-defense peptides (HDPs), which are bifunctional peptides with both direct antimicrobial and immunomodulatory activities.
openaire   +5 more sources

Helminthic host defense peptides: using the parasite to defend the host

Trends in Parasitology, 2023
Parasitic helminths are destined to share niches with a variety of microbiota that inevitably influence their interaction with the host. To modulate the microbiome for their benefit and defend against pathogenic isolates, helminths have developed host defense peptides (HDPs) and proteins as integral elements of their immunity.
Mladineo, Ivona, Rončević, Tomislav, Gerdol, Marco, Tossi, Alessandro   +3 more
openaire   +5 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. [PDF]

, 2017
OBJECTIVE: To evaluate (1) levels of the host-defense/antimicrobial peptide LL-37 in patients with trauma and hemorrhagic shock (HS) and (2) the effects of a synthetic host-defense peptide; Pep19-4LF on multiple organ failure (MOF) associated with HS ...
Barbara Varrone, Fausto Chiazza, Brohi, Karim, Massimo Collino, Thiemermann, Christoph, Noriaki Yamada, Gernot Marx, Varrone, Barbara, Elisabeth Zechendorf, Chiazza, F, Yamada, Noriaki, Karim Brohi, Zechendorf, Elisabeth, Heinbockel, Lena, Christoph Thiemermann, Gutsmann, T, Klaus Brandenburg, Correa, W, Martin, Lukas B., Brandenburg, Klaus, Thomas Gutsmann, Heinbockel, L, Purvis, Gareth S. D., Varrone, B, Lena Heinbockel, Purvis, GSD, Zechendorf, E, Martin, Lukas Benjamin, Schuerholz, T, Collino, M, Marx, Gernot, Tobias Schuerholz, Gareth S. D. Purvis, Lukas B. Martin, Yamada, N, Marx, G, Thiemermann, C, Gutsmann, Thomas, Correa, Wilmar, Wilmar Correa, CHIAZZA, FAUSTO, Martin, LB, Shepherd, Joanna, Schuerholz, Tobias, Brohi, K, Shepherd, J, Brandenburg, K, Joanna Shepherd, COLLINO, Massimo   +48 more
core   +1 more source

Antimicrobial Peptides as Mediators of Epithelial Host Defense [PDF]

Pediatric Research, 1999
Mammalian epithelial surfaces are remarkable for their ability to provide critical physiologic functions in the face of frequent microbial challenges. The fact that these mucosal surfaces remain infection-free in the normal host suggests that highly effective mechanisms of host defense have evolved to protect these environmentally exposed tissues ...
K M, Huttner, C L, Bevins
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Optimal antimicrobial response to a changing microbial background at a mucus interface

Physical Review Research
Complex lifeforms host microbiota, microbes that live synergistically with their host. Accordingly, hosts have mechanisms to defend against and tolerate the microbiota.
Guilherme Volpe Bossa, Shai Bel, Andrew Mugler, Amir Erez   +3 more
doaj   +1 more source