Results 71 to 80 of about 2,814,854 (281)
Host defense peptide-derived privileged scaffolds for anti-infective drug discovery
, 2017 'Privileged scaffolds' are molecular frameworks which have been successfully exploited for small molecule drug discovery. Peptide privileged scaffolds, featuring a strictly conserved multiple-disulfide framework and high variability in the rest of the ...
Pessi, Antonello +6 more
core +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
LL-37 Inhibits EV71 Infection by Upregulating STAC via the EGFR-ERK Signaling Pathway
VirusesLL-37, a 37-amino acid human-derived antimicrobial peptide, was shown in our earlier clinical study to shorten the negative conversion time of the Omicron BA.5.1.3 variant of SARS-CoV-2.
Jiaqi Zhang +10 more
doaj +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
, 2020 Multidrug-resistant (MDR) bacteria have emerged quickly and have caused serious nosocomial infections. It is urgent to develop novel antimicrobial agents for treating MDR bacterial infections.
Haodong Zhang (4417534) +19 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
PLoS Pathogens, 2013 Staphylococcus aureus contains an autoinducing quorum-sensing system encoded within the agr operon that coordinates expression of virulence genes required for invasive infection.
Pamela R Hall +13 more
doaj +1 more source
Neutrophil antimicrobial defense against Staphylococcus aureus. contribution of cathelicidin and the NADPH oxidase [PDF]
, 2009 Neutrophils are among the most important components of the innate immune response, which provides the first line of host defense. The antimicrobial potential of neutrophils has been traditionally divided into either non-oxidative or oxidative ...
Jann, Naja
core +1 more source
Dynamic Physicochemical Gradients for Tendon–Bone Regeneration
Advanced Functional Materials, EarlyView.Dynamic physicochemical gradients offer a framework for reconnecting soft tendon and hard bone. This Review examines how hydration, transport, loading and degradation reshape these gradients during healing. Coordinating regional biological cues with progressive transfer of load from scaffold to tissue guides the design of interfaces that retain ...
Wanxue Wang +11 more
wiley +1 more source