Results 91 to 100 of about 2,814,854 (281)

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

Advanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz, A. Bandyopadhyay, S. Belkin, S. Bose, N. Eliaz, J. L. Gilbert, T. C. Lowe, F. Mücklich, R. J. Turner, C. C. Tasan   +9 more
wiley   +1 more source

Tissue expression distribution characterization of the host defense peptide dCATH in Anas platyrhynchos

Biotechnology & Biotechnological Equipment, 2020
Cathelicidin host defense peptides (cHDPs) widely exist in animals with the functions of innate immunity and acquired immunity. To investigate the tissue and sequential expression patterns of the dCATH gene, which encodes the only cHDPs found in ...
Sanjun Jin, Qian Pang, Tingting Zhang, Min Wang, Hao Yang, Fangju Liu, Yingjie Wang, Anshan Shan, Xingjun Feng   +8 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Immuno-Stimulatory Peptides as a Potential Adjunct Therapy against Intra-Macrophagic Pathogens

Molecules, 2017
The treatment of infectious diseases is increasingly prone to failure due to the rapid spread of antibiotic-resistant pathogens. Antimicrobial peptides (AMPs) are natural components of the innate immune system of most living organisms.
Tânia Silva, Maria Salomé Gomes
doaj   +1 more source

Structural basis of ligand binding modes at the human formyl peptide receptor 2

Nature Communications, 2020
Formyl peptide receptors (FPRs) are GPCRs that play important roles in transducing chemotactic signals in phagocytes and mediating host-defense and inflammatory responses. Here the authors present the 2.8 Å crystal structure of human FPR2 in complex with
Tong Chen, Muya Xiong, Xin Zong, Yunjun Ge, Hui Zhang, Mu Wang, Gye Won Han, Cuiying Yi, Limin Ma, Richard D. Ye, Yechun Xu, Qiang Zhao, Beili Wu   +12 more
doaj   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

In Vitro Activities of Synthetic Host Defense Propeptides Processed by Neutrophil Elastase against Cystic Fibrosis Pathogens

, 2011
The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway ...
Timothy P. Smyth, Noel G McElvaney (7895978), Anusha P. Subasinghage, Dilip K. Rai, Stephane Desgranges (7956938), Noel G. McElvaney, Deirdre Fitzgerald Hughes (7895360), Timothy P. Smyth (2702662), Jennifer Lydon, Marian Brennan, Florie Le Prieult (8010023), Catherine Greene (7895252), Marian Brennan (7895849), Sally-Ann Cryan, Florie Le Prieult, Alan Daly, Marc Devocelle (7895822), Marc Devocelle, Alan Daly (6187994), Jennifer Lydon (10045868), Deirdre Fitzgerald-Hughes, Chandralal M. Hewage (2474131), Sally-Ann Cryan (7896101), Hilary Humphreys, Catherine Greene, Chandralal M. Hewage, Hilary Humphreys (7895573), Anusha P. Subasinghage (8010026), Stephane Desgranges, Dilip K. Rai (2032831), Le Prieult, Florie, Fitzgerald-Hughes, Deirdre, Rai, Dilip K, Greene, Catherine, Humphreys, Hilary, Devocelle, Marc, Lydon, Jennifer, Hewage, Chandralal M, Desgranges, Stephane, Brennan, Marian, Daly, Alan, Cryan, Sally-Ann, Smyth, Timothy P, Subasinghage, Anusha P, McElvaney, Noel G   +44 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Human host defense peptide LL-37 prevents bacterial biofilm formation [PDF]

, 2008
The ability to form biofilms is a critical factor in chronic infections by Pseudomonas aeruginosa and has made this bacterium a model organism with respect to biofilm formation.
Bains, Manjeet, Hancock, Robert EW, Overhage, Joerg, Torfs, Ellen CW, Rehm, Bernd HA, Campisano, Andrea   +5 more
core   +1 more source