Results 111 to 120 of about 2,814,854 (281)

Host defense skin peptides vary with color pattern in the highly polymorphic red-eyed treefrog

Frontiers in Ecology and Evolution, 2016
Patterns of phenotypic variation across a geographic range provide important insights into evolutionary processes underlying diversification and speciation. Most evolutionary studies use putatively neutral markers to examine evolutionary diversification.
Leyla Rivero Davis, Leyla Rivero Davis, Karina Klonoski, Heidi L Rutschow, Klaas Van Wijk, Qi Sun, Meena M Haribal, Ralph A Saporito, Andres Vega, Erica B Rosenblum, Kelly R Zamudio, Jeanne M Robertson   +11 more
doaj   +1 more source

A Paneth cell analogue in Xenopus small intestine expresses antimicrobial peptide genes: conservation of an intestinal host-defense system.

, 1994
Antimicrobial peptides are a widespread component of host defense. We characterized the tissue distribution and cellular localization of expression of the magainin family of antimicrobial peptide genes in Xenopus laevis.
C L Bevins, M Zasloff, N Tomassini, D S Reilly   +3 more
core   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Surface Modified with a Host Defense Peptide-Mimicking β‑Peptide Polymer Kills Bacteria on Contact with High Efficacy

, 2018
Methicillin-resistant Staphylococcus aureus (MRSA) has been one of the major nosocomial pathogens to cause frequent and serious infections that are associated with various biomedical surfaces.
Yanyong Cheng (5135036), Si Zhang (111568), Ting Wei (113015), Zhongqian Qiao (5135030), Qiang Zhang (45005), Changyou Gao (1553950), Yiru Ding (5135033), Shan Yu (219591), Runhui Liu (435734), Fan Qi (5135039), Qi Chen (144168), Qian Yu (127062), Chenyu Jin (2113756), Zhengwei Mao (1795357), Yuxin Qian (2130250), Hexin Xie (1479064)   +15 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Functionalization of nanofibrillated cellulose with the host defense peptide KR-12

, 2021
When the process of wound healing is disturbed, chronic wounds may develop. Chronic wounds heal very slowly over long periods of time, and require specialised care in order to prevent further infection.
Pavelescu, Alina
core   +2 more sources

Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection

, 2020
Regulated antimicrobial peptide expression in the intestinal epithelium is key to defense against infection and to microbiota homeostasis. Understanding the mechanisms that regulate such expression is necessary for understanding immune homeostasis and ...
Wani, Khursheed A, Labed, Sid Ahmed, Najibi, Mehran, Hakkim, Abdul, Irazoqui, Javier E, Jagadeesan, Sakthimala   +5 more
core   +1 more source

Multifunctional host defense peptides: intracellular‐targeting antimicrobial peptides [PDF]

The FEBS Journal, 2009
There is widespread acceptance that cationic antimicrobial peptides, apart from their membrane‐permeabilizing/disrupting properties, also operate through interactions with intracellular targets, or disruption of key cellular processes. Examples of intracellular activity include inhibition of DNA and protein synthesis, inhibition of chaperone‐assisted ...
openaire   +2 more sources

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Host defense peptides in malaria infection: their contributions, significance and constraints

Malaria Journal
Plasmodium-induced malaria infection remains a leading global health threat. Host defense peptides (HDPs), key components of innate immunity, target multiple stages of Plasmodium development through direct antimicrobial activity and immunomodulation ...
Dia Aldeen Alfaki, Mohamed Mubarak Elbasheir   +1 more
doaj   +1 more source