Results 81 to 90 of about 2,814,854 (281)

An endogenous danger detection system in "Arabidopsis thaliana": the AtPep peptides and their receptors [PDF]

, 2014
Plants use a plethora of sophisticated detection systems to recognize a variety of attackers and to subsequently initiate defense responses. A well-known paradigm in this context is the perception of microbe-associated molecular patterns (MAMPs) by ...
Klauser, Dominik Roman
core   +1 more source

Expression and Function of Host Defense Peptides at Inflammation Sites [PDF]

International Journal of Molecular Sciences, 2019
There is a growing interest in the complex role of host defense peptides (HDPs) in the pathophysiology of several immune-mediated inflammatory diseases. The physicochemical properties and selective interaction of HDPs with various receptors define their immunomodulatory effects. However, it is quite challenging to understand their function because some
Suhanya V. Prasad, Krzysztof Fiedoruk, Tamara Daniluk, Ewelina Piktel, Robert Bucki   +4 more
openaire   +3 more sources

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens

Frontiers in Immunology, 2019
The mammalian intestine is colonized by over a trillion microbes that comprise the “gut microbiota,” a microbial community which has co-evolved with the host to form a mutually beneficial relationship.
Hong-Yu Cheng, Meng-Xia Ning, De-Kun Chen, Wen-Tao Ma   +3 more
doaj   +1 more source

Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability

Frontiers in Microbiology, 2020
Can antimicrobial activity and peptide stability of alpha-helical peptides be increased by making them into dimers and macrocycles? Here, we explore that concept by using KR-12 as the starting point for peptide engineering.
Sunithi Gunasekera, Taj Muhammad, Adam A. Strömstedt, K. Johan Rosengren, Ulf Göransson   +4 more
doaj   +1 more source

At the frontier; RXLR effectors crossing the Phytophthora -host interface [PDF]

, 2011
Plants are constantly beset by pathogenic organisms. To successfully infect their hosts, plant pathogens secrete effector proteins, many of which are translocated to the inside of the host cell where they manipulate normal physiological processes and ...
Meijer, H.J.G., Francine eGovers, Govers, F., Bouwmeester, K., Klaas eBouwmeester, Harold J. G. Meijer, Francine Govers, Harold. J.G. eMeijer, Klaas Bouwmeester   +8 more
core   +1 more source

Engineering Antigen Density on M13 Bacteriophage for Personalized Nanovaccine

Advanced Healthcare Materials, EarlyView.
Increasing antigen density on the phage capsid impacts phage uptake and antigen cross‐presentation by antigen‐presenting cells, leading to enhanced activation of antitumor CD8+ T cells in the draining lymph nodes. These activated CD8+ T cells subsequently recognize the antigen‐expressing tumors and mediate their specific cytotoxic killing, thereby ...
Shengnan Huang, Allison Madow, Jack Rudrum, Huaiyao Peng, Hao Nghi Luu, Peiyan Dong, Jifa Qi, Angela M. Belcher   +7 more
wiley   +1 more source

RNA selectively modulates activity of virulent amyloid PSMα3 and host-defense LL-37 via phase separation and aggregation dynamics

eLife
Amyloid-forming peptides are increasingly recognized as dynamic regulators at the host–pathogen interface, yet how environmental factors control their assembly and activity remains poorly understood.
Bader Rayan, Eilon Barnea, Rinat Indig, Christian F Pantoja, Jesse Gayk, Yael Lupu-Haber, Alexander Upcher, Amir Argoetti, Jacob Aunstrup Larsen, Alexander Kai Buell, Markus Zweckstetter, Meytal Landau   +11 more
doaj   +1 more source

The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes

, 2015
Host defense peptides have recently gained much interest as novel anti-infectives owing to their ability to kill bacteria and simultaneously modulate host cell responses.
Hansen, Finja, Kalle, Martina, Strömdahl, Ann-Charlotte, van der Plas, Mariena, Malmsten, Martin, Schmidtchen, Artur, Malmsten, Martin,, Hansen, Finja C., Kalle-Brune, Martina, van der Plas, Mariena J. A., Mörgelin, Matthias, Strömdahl, Ann-Charlotte,, Hansen, Finja,, Mörgelin, Matthias,, Kalle, Martina,, Schmidtchen, Artur,, van der Plas, Mariena,, Lund University.   +17 more
core   +1 more source

Multifunctional host defense peptides: antiparasitic activities [PDF]

The FEBS Journal, 2009
Whereas significant knowledge is accumulating on the antibacterial and antifungal properties of host defense peptides (HDPs) and their synthetic mimics, much less is known of their activities against parasites. A variety of in vitro and in vivo antiparasitic assays suggest that these notorious antimicrobial compounds could represent a powerful tool for
openaire   +2 more sources