Results 21 to 30 of about 2,814,854 (281)

Polyproline Peptide Aggregation with Klebsiella pneumoniae Extracellular Polysaccharides Exposes Biofilm Associated Bacteria

Microbiology Spectrum, 2022
Klebsiella pneumoniae produces a thick capsule layer composed of extracellular polysaccharides protecting the bacterial cells from clearance by innate host immunity during infection.
Renee M. Fleeman, Bryan W. Davies
doaj   +1 more source

The future of recombinant host defense peptides

Microbial Cell Factories, 2022
Abstract The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities that are attractive for translational applications, with several already under clinical trials.
Ramon Roca-Pinilla, Leszek Lisowski, Anna Arís, Elena Garcia-Fruitós   +3 more
openaire   +3 more sources

The Intracellularly Acting Effector Foa3 Suppresses Defense Responses When Infiltrated Into the Apoplast

Frontiers in Plant Science, 2022
Plant pathogens employ secreted proteins, among which are effectors, to manipulate and colonize their hosts. A large fraction of effectors is translocated into host cells, where they can suppress defense signaling.
Nico Tintor, Gea A. M. Nieuweboer, Ilse A. W. Bakker, Frank L. W. Takken   +3 more
doaj   +1 more source

Antimicrobial peptides in echinoderm host defense [PDF]

Developmental & Comparative Immunology, 2015
Antimicrobial peptides (AMPs) are important effector molecules in innate immunity. Here we briefly summarize characteristic traits of AMPs and their mechanisms of antimicrobial activity. Echinoderms live in a microbe-rich marine environment and are known to express a wide range of AMPs. We address two novel AMP families from coelomocytes of sea urchins:
Li, Chun, Blencke, Hans-Matti, Haug, Tor, Stensvåg, Klara   +3 more
openaire   +3 more sources

Blocking SARS-CoV‑2 Delta Variant (B.1.617.2) Spike Protein Receptor-Binding Domain Binding with the ACE2 Receptor of the Host Cell and Inhibiting Virus Infections Using Human Host Defense Peptide-Conjugated Graphene Quantum Dots [PDF]

ACS Omega, 2022
Avijit Pramanik, Poonam C. Sharma, Shamily Patibandla, Ye Gao, Vinod Ruppa-Kasani, Jagruti Goli, Animesh Kumar, Abhirup Chatterjee, Sudarson Sekhar Sinha, John T. Bates, Michael A. Bierdeman, Ritesh Tandon, Paresh Chandra Ray   +12 more
doaj   +2 more sources

Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers

Bioactive Materials, 2021
It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical devices. Host defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant microbes. Our
Ziyi Lu, Yueming Wu, Zihao Cong, Yuxin Qian, Xue Wu, Ning Shao, Zhongqian Qiao, Haodong Zhang, Yunrui She, Kang Chen, Hengxue Xiang, Bin Sun, Qian Yu, Yuan Yuan, Haodong Lin, Meifang Zhu, Runhui Liu   +16 more
doaj   +1 more source

Bacterial Evasion of Host Antimicrobial Peptide Defenses [PDF]

Microbiology Spectrum, 2016
ABSTRACT Antimicrobial peptides (AMPs), also known as host defense peptides, are small naturally occurring microbicidal molecules produced by the host innate immune response that function as a first line of defense to kill pathogenic microorganisms by inducing deleterious cell membrane damage.
Cole, Jason N., Nizet, Victor
openaire   +5 more sources

Antiviral potential of cathelicidins [PDF]

, 2014
The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow.
Davidson, Donald J, Barlow, Peter G, Gwyer Findlay, Emily, Findlay, Emily Gwyer, Currie, Silke M, Davidson, D.J., Barlow, Peter G., Findlay, E.G., Currie, S.M.   +8 more
core   +1 more source

Immunomodulatory Activities of Small Host Defense Peptides [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACT Recent studies have demonstrated that in addition to their antimicrobial activity, cationic host defense peptides, like the human cathelicidin LL-37, perform many activities relating to innate immunity, including the induction or modulation of chemokine and cytokine production, alteration of gene ...
Bowdish, Dawn M E, Davidson, Donald J, Scott, Monisha G, Hancock, Robert E W   +3 more
openaire   +2 more sources

The Host Defense Proteome of Human and Bovine Milk [PDF]

, 2011
Milk is the single source of nutrients for the newborn mammal. The composition of milk of different mammals has been adapted during evolution of the species to fulfill the needs of the offspring.
Hooijdonk, A.C.M., van, Jacques Vervoort, Boeren, S., Hein van Valenberg, Vervoort Jacques, van Valenberg Hein, Sacco de Vries, de Vries Sacco, Boeren Sjef, Hettinga Kasper, Vries, S.C., de, Valenberg, H.J.F., van, Hettinga, K.A., van Hooijdonk Toon, Kasper Hettinga, Sjef Boeren, Arendonk, J.A.M., van, Toon van Hooijdonk, Johan van Arendonk, van Arendonk Johan, Vervoort, J.J.M.   +20 more
core   +2 more sources