Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer [PDF]
Cellular Physiology and Biochemistry, 2018 LL-37, the C-terminal peptide of human cathelicidin antimicrobial peptide (CAMP, hCAP18), reportedly increases resistance to microbial invasion and exerts important physiological functions in chemotaxis, promotion of wound closure, and angiogenesis ...
Xi Chen +6 more
doaj +4 more sources
SP-LL-37, human antimicrobial peptide, enhances disease resistance in transgenic rice. [PDF]
PLoS ONE, 2017 Human LL-37 is a multifunctional antimicrobial peptide of cathelicidin family. It has been shown in recent studies that it can serve as a host's defense against influenza A virus.
In Hye Lee +6 more
doaj +2 more sources
Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism. [PDF]
PLoS ONE, 2014 Pyroptosis is a caspase-1 dependent cell death, associated with proinflammatory cytokine production, and is considered to play a crucial role in sepsis.
Zhongshuang Hu +6 more
doaj +2 more sources
The role of the human cathelicidin LL-37 in rhinovirus infection [PDF]
, 2019 Human rhinoviruses (HRVs) are the most common causes for symptomatic respiratory infections, and have been linked to severe respiratory conditions in children, and in immunocompromised and elderly individuals. Currently there are no specific treatments or vaccination available for HRV infections and novel antiviral therapeutics are urgently required ...
Henderson Sousa, Filipa
openaire +2 more sources
Structural and Functional Analysis of the Pro-Domain of Human Cathelicidin, LL-37 [PDF]
Biochemistry, 2013 Cathelicidins form a family of small host defense peptides distinct from another class of cationic antimicrobial peptides, the defensins. They are expressed as large precursor molecules with a highly conserved pro-domain known as the cathelin-like domain (CLD).
Pazgier, Marzena +12 more
openaire +5 more sources
Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. [PDF]
PLoS ONE, 2011 The extensive world-wide morbidity and mortality caused by influenza A viruses highlights the need for new insights into the host immune response and novel treatment approaches. Cationic Host Defense Peptides (CHDP, also known as antimicrobial peptides),
Peter G Barlow +7 more
doaj +2 more sources
International Journal of Nanomedicine, 2015 Katarzyna Niemirowicz,1 Izabela Prokop,2 Agnieszka Z Wilczewska,3 Urszula Wnorowska,1 Ewelina Piktel,1 Marzena Wątek,4 Paul B Savage,5 Robert Bucki1,6 1Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok ...
Niemirowicz K +7 more
doaj +1 more source
Cathelicidin LL-37 in Health and Diseases of the Oral Cavity. [PDF]
Biomedicines, 2022 The mechanisms for maintaining oral cavity homeostasis are subject to the constant influence of many environmental factors, including various chemicals and microorganisms. Most of them act directly on the oral mucosa, which is the mechanical and immune barrier of the oral cavity, and such interaction might lead to the development of various oral ...
Tokajuk J +8 more
europepmc +5 more sources
Cathelicidin LL-37 promotes EMT, migration and metastasis of hepatocellular carcinoma cells in vitro and mouse model. [PDF]
Cell Adh Migr, 2023 The effect of cathelicidin hCAP18/LL-37 in hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we confirmed that LL-37 expression enhanced endothelial-mesenchymal transition (EMT), migration and invasion in HCC cells.
Zhang H +5 more
europepmc +3 more sources
Circulating cathelicidin LL-37 in adult patients with pulmonary infectious diseases
Clinical and Investigative Medicine, 2017 Purpose The antimicrobial peptide cathelicidin LL-37 plays a role in the immune response in the course of lung infections; however, the exact role of LL-37 in defense mechanisms against bacteria within the respiratory tract is has not been precisely described.
Karol, Majewski +2 more
core +5 more sources