Results 41 to 50 of about 52,950,106 (199)

Susceptibility of Pseudomonas aeruginosa biofilm to alpha-helical peptides: D-enantiomer of LL-37

Frontiers in Cellular and Infection Microbiology, 2011
Pseudomonas aeruginosa is a highly versatile opportunistic pathogen and its ability to produce biofilms is a direct impediment to the healing of wounds and recovery from infection.
Scott N. Dean, Barney M. Bishop, Monique L Van Hoek   +2 more
doaj   +1 more source

Significance of LL-37 on Immunomodulation and Disease Outcome [PDF]

, 2020
LL-37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial ...
Yi, Zhengjun, Yang, Binbin, Good, David, Mosaiab, Tamim, Liu, Xiaosong, Jessop, Calvin, Yang, Lu, Liu, Wei, Fadhil, Rushdi, Ni, Guoying, Kaur, Jasmine, Wei, Ming Q   +11 more
core   +1 more source

Cathelicidin LL-37: An Antimicrobial Peptide with a Role in Inflammatory Skin Disease [PDF]

Annals of Dermatology, 2012
Chronic inflammatory skin diseases such as atopic dermatitis, psoriasis or rosacea are very common. Although their exact pathogenesis is not completely understood all three diseases are characterized by dysregulation of cutaneous innate immunity. Cathelicidin LL-37 is an important effector molecule of innate immunity in the skin and atopic dermatitis ...
Reinholz, Markus, Ruzicka, Thomas, Schauber, Jürgen   +2 more
openaire   +2 more sources

In silico assessment of missense point mutations on human cathelicidin LL-37 [PDF]

Journal of Molecular Graphics and Modelling, 2021
Abstract Cathelicidin antimicrobial peptides are a diverse family of cationic amphipathic peptides with multiple activities. In humans, cathelicidin LL-37 is one of the main host defense peptides with a remarkable medical and biotechnological potential.
William F. Porto, Sergio A. Alencar
openaire   +2 more sources

Human cathelicidin LL-37-derived peptide IG-19 confers protection in a murine model of collagen-induced arthritis [PDF]

, 2014
Current therapies for autoimmune chronic inflammatory diseases e.g. rheumatoid arthritis (RA) include inhibitors of inflammatory cytokines. However, these therapies can result in increased risk of infections.
Bossart, Maike, Choi, Ka-Yee Grace, Mookherjee, Neeloffer, Uzonna, Jude, Piyadasa, Hadeesha, Klonisch, Thomas, Chow, Leola, Maike Bossert, Thomas Klonisch, Ka-Yee (Grace) Choi, Leola N.Y. Chow, Jude Uzonna, Hadeesha Piyadasa, Neeloffer Mookherjee   +13 more
core   +1 more source

Multifunctional Roles of Human Cathelicidin (LL-37) at the Ocular Surface

Investigative Opthalmology & Visual Science, 2006
The goals of this study were to examine the expression of the antimicrobial peptide LL-37 in the corneal epithelium during wound healing and to investigate whether LL-37 stimulates human corneal epithelial cell (HCEC) migration, proliferation, and cytokine production.Expression of LL-37 was determined by RT-PCR and immunostaining in tissue sections and
Ling C, Huang, Tihomira D, Petkova, Rose Y, Reins, Rita J, Proske, Alison M, McDermott   +4 more
openaire   +2 more sources

Human cathelicidin production by the cervix.

PLoS ONE, 2014
hCAP18/LL-37 is the sole human cathelicidin; a family of host defence peptides with key roles in innate host defence. hCAP18/LL-37 is expressed primarily by neutrophils and epithelial cells, but its production and function in the lower genital tract is ...
Lorraine Frew, Sofia Makieva, Andrew T M McKinlay, Brian J McHugh, Ann Doust, Jane E Norman, Donald J Davidson, Sarah J Stock   +7 more
doaj   +1 more source

The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy

Pharmaceuticals, 2016
Influenza A virus (IAV) remains a major threat that can cause severe morbidity and mortality due to rapid genomic variation. Resistance of IAVs to current anti-IAV drugs has been emerging, and antimicrobial peptides (AMPs) have been considered to be ...
I-Ni Hsieh, Kevan L. Hartshorn
doaj   +1 more source

The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma

, 2010
BACKGROUND: Recent evidence suggests cathelicidin LL-37 to be a growth factor for various human cancers such as lung cancer, ovarian cancer and breast cancer. However, the effect of LL-37 against malignant skin cancer has not been reported.
정기양, 정진영
core   +1 more source

Evaluating the Antiviral Activities of Human Cathelicidin LL-37 Peptide Against Rotavirus in Vitro

The Journal of Qazvin University of Medical Sciences, 2019
Background Rotavirus is the most prevalent cause of severe gastroenteritis, hospitalizations, and deaths among infants and young children, globally. No specific antiviral drug is available against rotavirus infection. Objective The current study aimed
Zohreh Hosseini, Angila Ataei-Pirkooh, Mohammad Bagher Habibi Najafi, Masoud Yavarmanesh   +3 more
doaj   +1 more source