Results 61 to 70 of about 52,950,106 (199)

Expression of human cathelicidin peptide LL-37 in inflammatory bowel disease [PDF]

Clinical and Experimental Immunology, 2017
Summary Cathelicidin peptide LL-37 plays an important role in the early host response against invading pathogens via its broad-spectrum anti-microbial activity. In this study, we investigated LL-37 expression in the inflamed mucosa of inflammatory bowel disease (IBD) patients.
S Kusaka, A Nishida, K Takahashi, S Bamba, H Yasui, M Kawahara, O Inatomi, M Sugimoto, A Andoh   +8 more
openaire   +2 more sources

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Structural and Functional Analysis of the Pro-Domain of Human Cathelicidin, LL-37

, 2016
Cathelicidins form a family of small host defense peptides distinct from another class of cationic antimicrobial peptides, the defensins. They are expressed as large precursor molecules with a highly conserved pro-domain known as the cathelin-like domain
Liqiong Lan (1985242), Marzena Pazgier (481212), Bryan Ericksen (483826), Edwin Pozharski (1264725), Weirong Yuan (483828), Guozhang Zou (1631764), Wuyuan Lu (363836), Changyou Zhan (483827), Amy Galliher-Beckley (1985245), Xiangdong Li (343463), Eric Toth (1985248), Minhua Ling (126490), Jishu Shi (1985239)   +12 more
core   +1 more source

Cathelicidin (LL-37) level in the scalp hair of patients with tinea capitis [PDF]

Medical Mycology, 2016
Antimicrobial peptides (AMPs) are considered an important first line of defense against pathogens. Cathelicidin LL-37 was upregulated in response to fungal infection. In this work we aimed to evaluate cathelicidin LL-37 in the hair of tinea capitis and compare it to normal controls. Hair samples were collected from 30 children and 30 controls aged from
Nagwa H, Abdelaal, Laila A, Rashed, Sahar Y, Ibrahim, Mona H, Abd El Halim, Noha, Ghoneim, Noha A, Saleh, Marwah A, Saleh   +6 more
openaire   +2 more sources

Stimuli‐Responsive Lipid‐Based Nanocarriers for Antimicrobial Therapy

Advanced Therapeutics, Volume 9, Issue 11, November 2026.
This manuscript demonstrated, through a scoping review of the literature, that modifying lipid nanocarriers with organic and inorganic excipients is a promising alternative to increase in vitro drug release of antimicrobial compounds under the studied stimulus and significantly enhance in vitro and in vivo antimicrobial activity compared to isolated ...
Brenda Maria Silva Bezerra, Adrian Lima Roberto, Luiz Gustavo Girão Lima, Mariana Rillo Sato, Leila Aparecida Chiavacci, João Augusto Oshiro‐Junior   +5 more
wiley   +1 more source

Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated FibrosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Cathelicidin (LL-37 in human and mCRAMP in mice) represents a family of endogenous antimicrobial peptides with anti-inflammatory effects.
Jun Hwan Yoo, Samantha Ho, Deanna Hoang-Yen Tran, Michelle Cheng, Kyriaki Bakirtzi, Yuzu Kubota, Ryan Ichikawa, Bowei Su, Diana Hoang-Ngoc Tran, Tressia C. Hing, Irene Chang, David Q. Shih, Richard E. Issacson, Richard L. Gallo, Claudio Fiocchi, Charalabos Pothoulakis, Hon Wai Koon   +16 more
doaj   +1 more source

Immunomodulatory Role of the Antimicrobial LL-37 Peptide in Autoimmune Diseases and Viral Infections

Vaccines, 2020
Antimicrobial peptides (AMPs) are produced by neutrophils, monocytes, and macrophages, as well as epithelial cells, and are an essential component of innate immunity system against infection, including several viral infections.
Bapi Pahar, Stefania Madonna, Arpita Das, Cristina Albanesi, Giampiero Girolomoni   +4 more
doaj   +1 more source

Helicobacter pylori Infection Remodels Neutrophil‐Derived Extracellular Vesicles, Promoting Stress and Apoptosis in Infected Epithelial Cells

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
We report that Helicobacter pylori reprograms neutrophils to release extracellular vesicles (HPN‐EVs) with distinct biophysical and molecular features. These neutrophil‐derived vesicles, enriched in neutrophil granule proteins, LL‐37 and pro‐apoptotic miRNAs, suppress epithelial PI3K/Akt signalling, increase ROS, and induce mitochondrial dysfunction ...
Anand Kumar Keshri, Suraj Singh Rawat, Durganand Thakur, Swati Sharma, Parul Mehra, Anubha Chaudhary, Ananaya Kapoor, Amit Prasad   +7 more
wiley   +1 more source

Influence of Vitamin D Deficiency on the Level of Salivary cathelicidin LL-37 in relation to Dental Caries Experience: A Case-Control Study

مجله كليه طب الكندي, 2023
Background: Vitamin D improves innate immunity by enhancing the expression of antimicrobial peptides. The antimicrobial action of cathelicidin is widespread and effective against cariogenic bacteria.
Narjes M. Alhelfi, Nibal M. Hobi
doaj   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, Volume 13, Issue 56, 9 October 2026.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source