Results 71 to 80 of about 52,950,106 (199)

Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. [PDF]

PLoS ONE, 2015
The human cathelicidin LL-37 has been shown to play a role in host defense against influenza A viruses (IAV) through direct antiviral effects and through modulating inflammatory responses to infection.
Shweta Tripathi, Guangshun Wang, Mitchell White, Michael Rynkiewicz, Barbara Seaton, Kevan Hartshorn   +5 more
doaj   +1 more source

Long-Lasting Stable Expression of Human LL-37 Antimicrobial Peptide in Transgenic Barley Plants

Antibiotics, 2021
Antimicrobial peptides play a crucial role in the innate immune system of multicellular organisms. LL-37 is the only known member of the human cathelicidin family.
Malihe Mirzaee, Edita Holásková, Alžbeta Mičúchová, David J. Kopečný, Zhila Osmani, Ivo Frébort   +5 more
doaj   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Polyphenols as Natural Therapeutics for Dental Infections and Oral Inflammation: Mechanisms and Clinical Perspectives

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Polyphenol‐rich plant extracts provide natural immunomodulatory protection for oral health through complementary antioxidant, antibacterial, and anti‐inflammatory actions. Their potential to reduce harmful microbial activity and inflammation highlights the promise of dietary polyphenols as a natural strategy for maintaining oral health and preventing ...
Deepa Subramanian, Divya Krishnamoorthi, Gowtham Kannan, Benedict Mathews Paul   +3 more
wiley   +1 more source

Supplementary Material for: Signaling Pathways Mediating Chemokine Induction in Keratinocytes by Cathelicidin LL-37 and Flagellin

, 2017
Cathelicidin LL-37 is a multifunctional immunomodulatory and antimicrobial host defense peptide that has an important role in the immune defenses of the skin and other epithelial barriers.
Hancock R.E.W. (4131289), Filewod N.C.J. (4131286), Pistolic J. (4131292), Nijnik A. (4131295)   +3 more
core   +1 more source

Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis. [PDF]

, 2014
BACKGROUND Loss-of-function point mutations in the cathepsin C gene are the underlying genetic event in patients with Papillon-Lefèvre syndrome (PLS).
Guentsch, A., Schacher, B., Eickholz, P., Puklo, Magdalena, Jan Potempa, Stennicke, Henning, Henning Stennicke, Hiemstra, Pieter, Peter Eickholz, Tomasz Kantyka, Adamowicz, Karina, Karina Adamowicz, Guentsch, Arndt, Magdalena Puklo, Stennicke, H., Eick, S., Potempa, J., Puklo, M., Eick, Sigrun, Potempa, Jan, Hiemstra, P., Kantyka, Tomasz, Pieter Hiemstra, Eickholz, Peter, Beate Schacher, Sigrun Eick, Adamowicz, K., Kantyka, T., Arndt Guentsch, Schacher, Beate   +29 more
core   +3 more sources

The role of endogenous antibacterial peptides in pneumonia occurrence among children of young age

Zdorovʹe Rebenka, 2017
The comprehensive examination included 204 children with community-acquired pneumonia aged 2 months to 3 years. It was found that in young children with community-acquired pneumonia, the main etiologic factor is bacteria Streptococcus pneumoniae (36.8 %).
G.O. Lezhenko, A.E. Abaturov, O.E. Pashkova, H.V. Kraynya   +3 more
doaj   +1 more source

Coptis chinensis Franch Directly Inhibits Proteolytic Activation of Kallikrein 5 and Cathelicidin Associated with Rosacea in Epidermal Keratinocytes

Molecules, 2020
Rosacea is a common and chronic inflammatory skin disease that is characterized by dysfunction of the immune and vascular system. The excessive production and activation of kallikerin 5 (KLK5) and cathelicidin have been implicated in the pathogenesis of ...
Kyung-Baeg Roh, De-Hun Ryu, Eunae Cho, Jin Bae Weon, Deokhoon Park, Dae-Hyuk Kweon, Eunsun Jung   +6 more
doaj   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Short, Synthetic Cationic Peptides Have Antibacterial Activity against Mycobacterium smegmatis by Forming Pores in Membrane and Synergizing with Antibiotics

Antibiotics, 2015
Multicellular organisms are constantly exposed to a multitude of pathogenic microbes. Infection is inhibited in vivo by the innate and adaptive immune system. Mycobacterium species have emerged that are resistant to most antibiotics.
Kajal Gupta, Sameer Singh, Monique L. van Hoek   +2 more
doaj   +1 more source