Results 211 to 220 of about 53,126,315 (234)

Optimized LL-37-Derived Peptides Exhibit Antitubercular Activity, Induce Membrane Disruption, and P-Type ATPase Transcriptional Responses in <i>Mycobacterium tuberculosis</i>. [PDF]

Biomolecules
Santos PA, Maya-Hoyos M, Salazar LM, Cruz CA, Cruz-Cacais A, Giraldo-Avila M, Gómez-Manchego J, Triana LV, Soto CY.   +8 more
europepmc   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

<i>LL-37</i> as a biomarker for therapeutic response to scaling and root planing. [PDF]

J Indian Soc Periodontol
Rao KS, Yadalam PK, Ravishankar PL, Rajula PB, Ravikumar H, Arunraj DR.   +5 more
europepmc   +1 more source

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

LAPTM5 exacerbates STING-mediated inflammation induced by LL-37 through stabilizing STING in rosacea. [PDF]

Commun Biol
Huang W, He H, Wu H, Wang Y, Wang J, Sun Y, Wang H, Yao S, Zhu L, Jiang Y, Cai X, Wu Y.   +11 more
europepmc   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Design and Screening of the Peptide SAMP-12aa Derived from LL-37, Which Exhibits Anti-<i>H. Pylori</i> Activity and Immunomodulatory Effects. [PDF]

Molecules
Lu J, Wang Q, Qin M, Dou J, Xiong Y, Zhang X.   +5 more
europepmc   +1 more source

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

LL-37-biofunctionalized titanium improves soft tissue seal surrounding the dental implant from the perspective of optimizing a race to the surface. [PDF]

Regen Biomater
Li Y, Huang J, Zhang Y, He Y, Cai D, Xu M, Ma Q, Zhang Y, Wang J.   +8 more
europepmc   +1 more source

Shear‐Mode Direct Piezoelectric Response of Ferroelectric Nematic Liquid Crystals

Advanced Science, EarlyView.
Periodic shear‐induced electric current measurements are reported on two archetypic ferroelectric nematic liquid crystal compounds. From the temperature, frequency and shear angle dependent results of the first and second harmonic current signals together with temperature and oscillatory rheology measurements, the effective piezoelectric coupling ...
Péter Salamon, Marcell Tibor Máthé, Hiroya Nishikawa, Fumito Araoka, Antal Jákli   +4 more
wiley   +1 more source