Results 101 to 110 of about 3,237 (188)

Two limb-specific enhancers control Lmx1b expression in a modular and autoregulatory manner

, 2022
Trabajo presentado en el EMBO Workshop: Enhanceropathies: understanding enhancer function to understand human disease, celebrado en Santander (España) del 06 al 09 de octubre de 2021.Lmx1b is the key regulator of dorso-ventral (DV) pattern in the limb ...
Castilla-Ibeas, Alejandro, Ros, María A., Galán, Laura, Zdral, Sofía, Oberg, Kerby C., Haro, Endika, Petit, Florence, Pira, Charmaine   +7 more
core  

Electron Microscopic and Immunohistochemical Findings of the Epidermal Basement Membrane in Two Families with Nail-patella Syndrome

Acta Dermato-Venereologica, 2019
Nail-patella syndrome is an autosomal dominant disorder characterized by nail dysplasia and skeletal anomaly. Some patients have been shown to have ultrastructural abnormalities of the glomerular basement membrane that result in nephrosis.
Satoru Shinkuma, Hideki Nakamura, Manami Maehara, Shota Takashima, Toshifumi Nomura, Yasuyuki Fujita, Satoshi Hasegawa, Kazuko C. Sato-Matsumura, Riichiro Abe, Hiroshi Shimizu   +9 more
doaj   +1 more source

Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish [PDF]

, 2009
To gain insight into the mechanisms of Lmx1b function during ocular morphogenesis, we have studied the roles of lmx1b.1 and lmx1b.2 during zebrafish eye development. In situ hybridization and characterization of transgenic lines in which GFP is expressed
Gestri, Gaia, Wilson, Stephen W., McMahon, Carrie, Link, Brian A.   +3 more
core   +1 more source

Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells.

PLoS ONE, 2015
Directed methods for differentiating human embryonic stem cells (hESCs) into dopaminergic (DA) precursor cells using stromal cells co-culture systems are already well established. However, not all of the hESCs differentiate into DA precursors using these
Mi-Sun Lim, Min-Seop Shin, Soo Young Lee, Yang-Ki Minn, Jeong-Kyu Hoh, Youl-Hee Cho, Dong-Wook Kim, Sang-Hun Lee, Chun-Hyung Kim, Chang-Hwan Park   +9 more
doaj   +1 more source

Electroacupuncture alleviates inflammatory pain via the activation of GABAergic inhibitory interneurons in mouse spinal dorsal horn

Brain Research Bulletin
Electroacupuncture (EA), a modern adaptation of traditional acupuncture, has shown promising analgesic effects across various pain models. However, the underlying central mechanisms remain insufficiently characterized.
Jiawei Zhang, Yang Bao, Mengye Zhu, Quan Wan, Jinjin Zhang, Xuezhong Cao, Huan Zou, Qinghua Yin, Ziming Chen, Gang Xu, Xuexue Zhang, Daying Zhang, Tao Liu, Yong Zhang   +13 more
doaj   +1 more source

Progress in Pathogenesis of Proteinuria

International Journal of Nephrology, 2012
Aims. Proteinuria not only is a sign of kidney damage, but also is involved in the progression of renal diseases as an independent pathologic factor. Clinically, glomerular proteinuria is most commonly observed, which relates to structural and functional
Aihua Zhang, Songming Huang
doaj   +1 more source

The IOP is elevated in Lmx1b^Icst/+ mice.

, 2014
(A) Box plot of IOP measurements of wild-type (WT) and Lmx1bIcst/+ (Het) mice taken at different ages. There is significantly elevated IOP in the Lmx1bIcst/+ mice up to 6 months (P = 0.006 at 2–3 months and P = 0.009 at 5–6 months).
Shalini Jadeja (561467), Richard S. Smith (50731), Ian J. Jackson (215017), Alison L. Kearney (561465), Margaret Keighren (256970), Danilo G. Macalinao (116351), Caroline Thaung (561466), Simon W. M. John (116361), Katrine West (561468), Stephen C. Kneeland (561469), Morag Robertson (561471), Gareth R. Howell (116343), Fiona Young (561470), Lisa McKie (214925), Joe Rainger (214922), Rob van t' Hof (561472), Sally H. Cross (561464), Lorraine Rose (496764)   +17 more
core   +1 more source

LMX1B Gene [PDF]

, 2020
openaire   +1 more source

Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach

European Journal of Medical Research
Background Chronic kidney disease presents global health challenges, with hemodialysis as a common treatment. However, non-dialyzable uremic toxins demand further investigation for new therapeutic approaches.
Roya Asadi, Pejman Shadpour, Akram Nakhaei   +2 more
doaj   +1 more source

Coordination of murine limb muscle, skeleton and connective tissue development by Lmx1b

, 2009
The underlying genetic defects of a congenital disease Nail-Patella Syndrome are loss-of-function mutations in the LMX1B gene. Lmx1b encodes a LIM-homeodomain transcription factor that is expressed specifically in the dorsal limb bud mesenchyme.
Li, Ying
core   +1 more source