Results 81 to 90 of about 3,237 (188)

Forced expression of Lmx1b enhances differentiation of mouse ES cells into serotonergic neurons [PDF]

, 2011
The LIM homeodomain transcription factor Lmx1b is a key factor in the specification of the serotonergic neurotransmitter phenotype. Here, we explored the capacity of Lmx1b to direct differentiation of mouse embryonic stem (mES) cells into serotonergic ...
Alenina, N., Kennedy, H., Yvonne van de Vrede, Virginie Dolmazon, Markossian, S., Jimmy Mancip, Michael Bader, Emeline Fontaine, Natalia Alenina, Suzy Markossian, Bernat, A., Fontaine, E., Henry Kennedy, Van de Vrede, Y., Colette Dehay, Dehay, C., Mancip, J., Agnieszka Bernat, Bader, M., Savatier, P., Pierre Savatier, Dolmazon, V.   +21 more
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Lmx1b regulation and function during limb development and evolution

, 2023
Trabajo presentado en el 19th International Congress of Developmental Biology, celebrado en Guia (Portugal) del 16 al 20 de octubre de 2022.The dorso-ventral (DV) limb asymmetry is crucial for its function; however, little is known about how it is ...
Naranjo, Silvia, Castilla-Ibeas, Alejandro, Galán, Laura, Ros, María A., Mate, Irene, Juliá, Miguel, Tena, Juan J., Zdral, Sofía, Oberg, Kerby C.   +8 more
core   +1 more source

Transcription Factors Define the Neuroanatomical Organization of the Medullary Reticular Formation

Frontiers in Neuroanatomy, 2013
The medullary reticular formation contains large populations of inadequately described, excitatory interneurons that have been implicated in multiple homeostatic behaviors including breathing, viserosensory processing, vascular tone, and pain.
Paul A Gray
doaj   +1 more source

Genetics of Common Obesity in Children and Adolescents

Annals of the New York Academy of Sciences, Volume 1553, Issue 1, Page 34-49, November 2025.
Abstract Childhood obesity is a multifactorial public health problem worldwide. Genetic variation influences the predisposition to develop obesity at early stages of life. Childhood obesity may be classified as syndromic, monogenic, or polygenic depending on the genetic component.
Guadalupe León‐Reyes, Francisco J. López Alavez, Maria Elizabeth Tejero   +2 more
wiley   +1 more source

Early dorsomedial tissue interactions regulate gyrification of distal neocortex

Nature Communications, 2019
The contribution of long-range signaling to cortical gyrification remains poorly understood. In this study, authors demonstrate that the combined genetic loss of transcription factors Lmx1a and Lmx1b, expressed in the telencephalic dorsal midline ...
Victor V. Chizhikov, Igor Y. Iskusnykh, Ekaterina Y. Steshina, Nikolai Fattakhov, Anne G. Lindgren, Ashwin S. Shetty, Achira Roy, Shubha Tole, Kathleen J. Millen   +8 more
doaj   +1 more source

4in1 Procedure in Treating Congenital Dislocation of Patella in Children

Orthopaedic Surgery, Volume 17, Issue 9, Page 2647-2652, September 2025.
Congenital dislocation of patella (CDP) is a rare condition. The 4in1 procedure includes lateral release, correction of quadriceps, Roux‐Goldthwait procedure, and medial patello‐femoral ligament (MPFL) reconstruction. Early diagnosis and the 4in1 procedure optimize patellar stability and knee function, preventing long‐term complications.
Meng‐jie Chen, Yi‐Chen Wang, Qi‐Chao Ma, Qin Zhang, Ting‐ting Li, Fang‐Chun Jin, Yi Luo   +6 more
wiley   +1 more source

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

Nature Communications, 2018
Primary open-angle glaucoma (POAG) leads to progressive vision loss. Here, Choquet et al. perform genome-wide association analysis for POAG in a multi-ethnic cohort, identify a total of nine novel genetic loci and show relevant function of FMNL2 and ...
Hélène Choquet, Seyyedhassan Paylakhi, Stephen C. Kneeland, Khanh K. Thai, Thomas J. Hoffmann, Jie Yin, Mark N. Kvale, Yambazi Banda, Nicholas G. Tolman, Pete A. Williams, Catherine Schaefer, Ronald B. Melles, Neil Risch, Simon W. M. John, K. Saidas Nair, Eric Jorgenson   +15 more
doaj   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, Volume 12, Issue 20, May 29, 2025.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielmann, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Lmx1b-targeted cis-regulatory modules involved in limb dorsalization

, 2017
Lmx1b is a homeodomain transcription factor responsible for limb dorsalization. Despite striking double-ventral (loss-of-function) and double-dorsal (gain-of-function) limb phenotypes, no direct gene targets in the limb have been confirmed.
Kerby C. Oberg, Billy A. Watson, Jennifer M. Feenstra, Subburaman Mohan, Luke Tegeler, Charmaine U. Pira, Endika Haro   +6 more
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