Results 61 to 70 of about 3,237 (188)

Foxa2 and Pet1 Direct and Indirect Synergy Drive Serotonergic Neuronal Differentiation

Frontiers in Neuroscience, 2022
Neuronal programming by forced expression of transcription factors (TFs) holds promise for clinical applications of regenerative medicine. However, the mechanisms by which TFs coordinate their activities on the genome and control distinct neuronal fates ...
Begüm Aydin, Michael Sierk, Mireia Moreno-Estelles, Mireia Moreno-Estelles, Link Tejavibulya, Nikathan Kumar, Nuria Flames, Shaun Mahony, Esteban O. Mazzoni   +8 more
doaj   +1 more source

Little Known Facts, Controversies and Misconceptions About Cranial Motor Nuclei (and a New Classification for All Motoneurons, Cranial, and Spinal)

Journal of Comparative Neurology, Volume 534, Issue 4, April 2026.
ABSTRACT Cranial nerves represent a notoriously complex province of the neuroanatomical landscape of the vertebrates. Here, we offer a selection of the anatomic, genetic, and developmental features of their efferent component that are often misrepresented, ignored or controversial, as a complement to more exhaustive treatments of the subject.
Margaux Sivori, Bowen Dempsey, Jean‐François Brunet   +2 more
wiley   +1 more source

LMX1B‐Regulated Nephrogenesis: A Role for Proteoglycans

The FASEB Journal, 2013
Lmx1b is a transcription factor necessary for kidney development. In humans, haploinsufficiency causes Nail Patella Syndrome frequently with chronic renal failure. In Lmx1b knockout mice, glomerular basement membrane formation is impaired, blocking filtration, urine production and long term survival.
Aldo Jhonathan Espinoza, Jennifer Feenstra, Charmaine Pira, Kerby Oberg   +3 more
openaire   +1 more source

Two Lmx1b-associated cis-regulatory modules (LARM1/2) mediate Lmx1b auto-amplification during limb dorsalization and their disruption can cause a limb-specific form of Nail-Patella syndrome [PDF]

, 2020
Trabajo presentado en Limb Development and Regeneration: New Tools for a Classic Model System EMBO Workshop, celebrado en Barcelona (España) del 2 al 5 de julio de 2019.During limb development, the Lmx1b homeodomain transcription factor is restricted to ...
Ros, María A., Jourdain, Anne-Sophie, Manouvrier-Hanu, Sylvie, Gray, Austin L., Spady, Conor, Ivey, Lauren, Francannet, Christine, Escande, Fabienne, Nguyen, Andy, Oberg, Kerby C., Haro, Endika, Good, Jean-Marc, Petit, Florence, Pira, Charmaine   +13 more
core  

Spatiotemporal Characterization of Anterior Segment Mesenchyme Heterogeneity During Zebrafish Ocular Anterior Segment Development

Frontiers in Cell and Developmental Biology, 2020
Assembly of the ocular anterior segment (AS) is a critical event during development of the vertebrate visual system. Failure in this process leads to anterior segment dysgenesis (ASD), which is characterized by congenital blindness and predisposition to ...
Kristyn L. Van Der Meulen, Oliver Vöcking, Megan L. Weaver, Nishita N. Meshram, Jakub K. Famulski   +4 more
doaj   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

The pyrogenic mediator prostaglandin E2 elicits warmth seeking via EP3 receptor‐expressing parabrachial neurons: a potential mechanism of chills

The Journal of Physiology, Volume 604, Issue 5, Page 2110-2130, 1 March 2026.
Abstract figure legend During infection, prostaglandin E2 (PGE2) is produced and elicits warmth‐seeking behaviour and involuntary febrile responses by acting on prostaglandin EP3 receptors (EP3Rs) in two distinct brain sites. PGE2 acting on EP3Rs on neurons in the external lateral part of the lateral parabrachial nucleus (LPBel) augments cold sensory ...
Takaki Yahiro, Yoshiko Nakamura, Kazuhiro Nakamura   +2 more
wiley   +1 more source

LMX1B and TFAP2 modulate TWIST1 enhancers.

, 2018
(A)In vitro eTw-5 activity in HEK293T cells following co-transfection with LMX1B or TFAP2 (TFAP2α and/or TFAP2γ) expression vectors. Luciferase activity was measured for the eTw-5 sequence and for deleted LMX1B (ΔLMX1B), TFAP2 (ΔTFAP2) or both LMX1B and ...
Darío G. Lupiáñez (5904614), Reut Eshel (5904602), Tal Shahar (3517382), Reut Bar Yaacov (5904605), Naama Hirsch (5904599), Tommy Kaplan (42606), Fania Shmulevich (5904608), Idit Dahan (5904611), Noam Levaot (5683499), Ramon Y. Birnbaum (139631)   +9 more
core   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source