Results 41 to 50 of about 4,807 (209)

LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult Kidneys [PDF]

Journal of the American Society of Nephrology, 2013
Mutations of the LMX1B gene cause nail-patella syndrome, a rare autosomal-dominant disorder affecting the development of the limbs, eyes, brain, and kidneys. The characterization of conventional Lmx1b knockout mice has shown that LMX1B regulates the development of podocyte foot processes and slit diaphragms, but studies using podocyte-specific Lmx1b ...
Burghardt, T., Kastner, J., Suleiman, H., Rivera-Milla, E., Stepanova, N., Lottaz, C., Kubitza, M., Boeger, C., Schmidt, S., Gorski, M., de Vries, U., Schmidt, H., Hertting, I., Kopp, J., Rascle, A., Moser, M., Heid, I., Warth, R., Spang, R., Wegener, J., Mierke, C., Englert, C., Witzgall, R.   +22 more
openaire   +3 more sources

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

, 2020
Stem-cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human pluripotent stem cells (hPSCs) differentiate into pancreatic islets in vitro by profiling DNA ...
Alvarez-Dominguez, J., Charlton, J., Donaghey, J., Helman, A., Kenty, J., Meissner, A., Melton, D., Rasouli, N., Straubhaar, J.   +8 more
core   +1 more source

Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem [PDF]

, 2014
BACKGROUND: Despite the importance of 5-HT1A as a major target for the action of several anxiolytics/antidepressant drugs, little is known about its regulation in central serotonin (5-hydroxytryptamine, 5-HT) neurons.
Chen, Zhou-Feng, Kim, Ana, Kim, Ji-Young, Liu, Xian-Yu, Zhou, Zhong-Qiu   +4 more
core   +2 more sources

LMX1B-associated nephropathy that showed myelin figures on electron microscopy [PDF]

CEN Case Reports, 2021
The mutation of LIM homeodomain transcription factor LMX1B gene leads to nail-patella syndrome (NPS), which is characterized by dysplastic nails, hypoplastic patellae, iliac horns and nephropathy. The characteristic renal histological finding of NPS nephropathy is irregular thickening of the glomerular basement membrane with patchy lucent areas ...
Homare Shimohata, Yusuke Miyake, Yu Yoshida, Joichi Usui, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Kouichi Hirayama, Masaki Kobayashi   +8 more
openaire   +2 more sources

A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].

PLoS Genetics, 2014
Mutations in the LIM-homeodomain transcription factor LMX1B cause nail-patella syndrome, an autosomal dominant pleiotrophic human disorder in which nail, patella and elbow dysplasia is associated with other skeletal abnormalities and variably nephropathy
Sally H Cross, Danilo G Macalinao, Lisa McKie, Lorraine Rose, Alison L Kearney, Joe Rainger, Caroline Thaung, Margaret Keighren, Shalini Jadeja, Katrine West, Stephen C Kneeland, Richard S Smith, Gareth R Howell, Fiona Young, Morag Robertson, Rob van T' Hof, Simon W M John, Ian J Jackson   +17 more
doaj   +1 more source

The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development [PDF]

, 2003
LIM homeobox family members regulate a variety of cell fate choices during animal development. In C. elegans, mutations in the LIM homeobox gene lin-11 have previously been shown to alter the cell division pattern of a subset of the 2° lineage vulval ...
Gupta, Bhagwati P., Sternberg, Paul W., Wang, Minqin   +2 more
core   +1 more source

Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe [PDF]

, 2016
Peer ...
Achim, Kaia, Haugas, Maarja, Partanen, Juha Matti, Salminen, Marjo Hannele, Tikker, Laura   +4 more
core   +1 more source

Fine mapping of bone structure and strength QTLs in heterogeneous stock rat [PDF]

, 2015
We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for
Alam, Imranul, Baud, Amelie, Blázquez, Gloria, Cañete, Toni, Diez, Margarita, Díaz-Morán, Sira, Econs, Michael J., Fernández-Teruel, Alberto, Foroud, Tatiana, Johannesson, Martina, Koller, Daniel L., López-Aumatell, Regina, Martínez-Membrives, Esther, Mont-Cardona, Carme, Olsson, Tomas, Stridh, Pernilla, Tobeña, Adolf   +16 more
core   +1 more source

LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer

Journal of Immunology Research, 2022
Prostate cancer (PCa) is the most common cancer affecting men, with increasing global mortality and morbidity rates. Despite the progress in the diagnosis and treatment of PCa, patient outcomes remain poor, and novel therapeutic targets for PCa are ...
Min Meng, Yi-chen Wu
doaj   +1 more source

Sox, Fox, and Lmx1b binding sites differentially regulate a Gdf5-Associated regulatory region during elbow development

Frontiers in Cell and Developmental Biology, 2023
Introduction: The articulating ends of limb bones have precise morphology and asymmetry that ensures proper joint function. Growth differentiation factor 5 (Gdf5) is a secreted morphogen involved in cartilage and bone development that contributes to the ...
Ruth-Love Yeboah, Charmaine U. Pira, Matthew Shankel, Allen M. Cooper, Endika Haro, Van-Dai Ly, Kenrick Wysong, Michael Zhang, Nicole Sandoval, Kerby C. Oberg   +9 more
doaj   +1 more source