Results 21 to 30 of about 3,237 (188)

Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes [PDF]

Journal of the American Society of Nephrology, 2014
Podocin is a key protein of the kidney podocyte slit diaphragm protein complex, an important part of the glomerular filtration barrier. Mutations in the human podocin gene NPHS2 cause familial or sporadic forms of renal disease owing to the disruption of filtration barrier integrity.
He, B, Ebarasi, L, Zhao, Z, Guo, J, Ojala, JR, Hultenby, K, De Val, S, Betsholtz, C, Tryggvason, K   +8 more
openaire   +3 more sources

Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives. [PDF]

Bioessays
Breathing is typically automatic, ensuring homeostasis, but it is also shaped by emotion, behavior, and volition. This review synthesizes our current understanding of the flexible neural mechanisms that enable multimodal control of breathing, emphasizing the role of pontomedullary circuits.
Baertsch NA, Reily E, Sedano J, Phillips RS, Arthurs JW.   +4 more
europepmc   +2 more sources

Identification of a novel missense variant in the LMX1B gene associated with nail-patella syndrome in a Chinese family [PDF]

Frontiers in Genetics
BackgroundNail-patella syndrome (NPS) is an autosomal dominant disorder caused by the variants of the LMX1B gene, affecting several systems, including musculoskeletal, renal, and ocular systems. Despite the well-established genetic basis, the complicated
Qian Sun, Yaqiong Ren, Yue Cao, Wen Zheng, Guanghao Su, Xiaodong Wang, Hongying Wang   +6 more
doaj   +2 more sources

Deciphering Lmx1b regulation during development and evolution

, 2023
Trabajo presentado en la 16th International Conference on Limb Development, regeneration, and evolution, celebrada en Cambridge (Estados Unidos) del 08 al 11 de agosto de 2022.
Zdral, Sofía, Castilla-Ibeas, Alejandro, Naranjo Duran, Silvia, Mate, Irene, Juliá, Miguel, Galán, Laura, Tena, Juan J., Ros, María A.   +7 more
openaire   +2 more sources

Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer [PDF]

Development, 2005
The mesencephalic and metencephalic region (MMR) of the vertebrate central nervous system develops in response to signals produced by the isthmic organizer (IsO). We have previously reported that the LIM homeobox transcription factor Lmx1b is expressed within the chick IsO, where it is sufficient to maintain expression of the secreted factor wnt1.
F Patrick, O'Hara, Ernestine, Beck, Lauren K, Barr, Lily L, Wong, Daniel S, Kessler, Robert D, Riddle   +5 more
  +5 more sources

Characterisation of lmx1b paralogues in zebrafish reveals divergent roles in skeletal, kidney and muscle development [PDF]

Biology Open
Joanna J. Moss, Chris R. Neal, Erika Kague, Jon D. Lane, Chrissy L. Hammond   +4 more
doaj   +3 more sources

Absence of digit tip regeneration in Lmx1b-deficient nailless digits suggests a role for Lmx1b distinct from patterning

, 2023
Trabajo presentado en el 19th International Congress of Developmental Biology, celebrado en Guia (Portugal) del 16 al 20 de octubre de 2022.
Castilla-Ibeas, Alejandro, Zdral, Sofía, Galán, Laura, Haro, Endika, Allou, Lila, Campa, Víctor M., Icardo, Jose M., Mundlos, Stefan, Oberg, Kerby C., Ros, María A.   +9 more
openaire   +2 more sources

Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1β-Induced Human Osteoarthritis Chondrocytes through NF-κB and NLRP3 Signal Pathway

Mediators of Inflammation, 2022
Osteoarthritis (OA), a chronic degenerative joint disease, always occurred in the aging population. There is evidence suggests that chondrocytes’ survival, inflammation, and apoptosis play critical roles in OA pathogenesis.
Yiping Mu, Lining Wang, Ling Fu, Qi Li
doaj   +1 more source

Lineage-specific mutation of Lmx1b provides new insights into distinct regulation of suture development in different areas of the calvaria

Frontiers in Physiology, 2023
The calvaria (top part of the skull) is made of pieces of bone as well as multiple soft tissue joints called sutures. The latter is crucial to the growth and morphogenesis of the skull, and thus a loss of calvarial sutures can lead to severe congenital ...
Angel Cabrera Pereira, Krishnakali Dasgupta, Thach-Vu Ho, Maria Pacheco-Vergara, Julie Kim, Niam Kataria, Yaowei Liang, Jeslyn Mei, Jeslyn Mei, Jinyeong Yu, Jinyeong Yu, Lukasz Witek, Lukasz Witek, Lukasz Witek, Yang Chai, Juhee Jeong   +15 more
doaj   +1 more source

Genetic analysis of a pedigree with nail-patella syndrome and literature review [PDF]

Xin yixue, 2023
Objective To analyze the clinical and molecular genetic features in one pedigree with nail-patella syndrome（NPS）， and provide evidence for genetic counseling and reproductive guidance for this family.
Liu Yingwen, Zhang Yuxin, Yan Lulu, Han Chunxiao, Li Haibo
doaj   +1 more source