Results 11 to 20 of about 4,807 (209)
LMX1B is part of a transcriptional complex with PSPC1 and PSF. [PDF]
PLoS ONE, 2013 The LIM homeodomain transcription factor Lmx1b is essential for the development of the isthmic organizer and mesodiencephalic dopaminergic neurons. The uncoupling of Pitx3 and Th expression, in the Lmx1b null mutant, suggests that Lmx1b may act as a ...
Elisa J Hoekstra +3 more
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Association of transcription factor gene LMX1B with autism. [PDF]
PLoS ONE, 2011 Multiple lines of evidence suggest a serotoninergic dysfunction in autism. The role of LMX1B in the development and maintenance of serotoninergic neurons is well known.
Ismail Thanseem +14 more
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Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons. [PDF]
PLoS ONE, 2015 Studying the development of mesodiencephalic dopaminergic (mdDA) neurons provides an important basis for better understanding dopamine-associated brain functions and disorders and is critical for establishing cell replacement therapy for Parkinson's ...
Orna Sherf +7 more
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Transcription Factors Define the Neuroanatomical Organization of the Medullary Reticular Formation [PDF]
Frontiers in Neuroanatomy, 2013 The medullary reticular formation contains large populations of inadequately described, excitatory interneurons that have been implicated in multiple homeostatic behaviors including breathing, viserosensory processing, vascular tone, and pain.
Paul A Gray
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Orthopedic manifestations and management of nail-patella syndrome: a narrative review [PDF]
Frontiers in PediatricsNail-patella syndrome (NPS) is a rare autosomal dominant disorder characterized by skeletal and renal abnormalities. Diagnosis is primarily clinical, based on four main features: nail dysplasia, patellar and elbow abnormalities, and the presence of iliac
Amandine Beaugé +6 more
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Characterisation of lmx1b paralogues in zebrafish reveals divergent roles in skeletal, kidney and muscle development [PDF]
Biology OpenJoanna J. Moss +4 more
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Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer [PDF]
Development, 2005 The mesencephalic and metencephalic region (MMR) of the vertebrate central nervous system develops in response to signals produced by the isthmic organizer (IsO). We have previously reported that the LIM homeobox transcription factor Lmx1b is expressed within the chick IsO, where it is sufficient to maintain expression of the secreted factor wnt1.
F Patrick, O'Hara +5 more
+5 more sources
Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. [PDF]
PLoS ONE, 2011 The transcription factor Lmx1b is essential for the differentiation and survival of central serotonergic (5-HTergic) neurons during embryonic development. However, the role of Lmx1b in adult 5-HTergic neurons is unknown.
Ning-Ning Song +8 more
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Mediators of Inflammation, 2022 Osteoarthritis (OA), a chronic degenerative joint disease, always occurred in the aging population. There is evidence suggests that chondrocytes’ survival, inflammation, and apoptosis play critical roles in OA pathogenesis.
Yiping Mu, Lining Wang, Ling Fu, Qi Li
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Frontiers in Physiology, 2023 The calvaria (top part of the skull) is made of pieces of bone as well as multiple soft tissue joints called sutures. The latter is crucial to the growth and morphogenesis of the skull, and thus a loss of calvarial sutures can lead to severe congenital ...
Angel Cabrera Pereira +15 more
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