Results 11 to 20 of about 3,237 (188)

LMX1B is part of a transcriptional complex with PSPC1 and PSF. [PDF]

PLoS ONE, 2013
The LIM homeodomain transcription factor Lmx1b is essential for the development of the isthmic organizer and mesodiencephalic dopaminergic neurons. The uncoupling of Pitx3 and Th expression, in the Lmx1b null mutant, suggests that Lmx1b may act as a ...
Elisa J Hoekstra, Simone Mesman, Willem A de Munnik, Marten P Smidt   +3 more
doaj   +8 more sources

Association of transcription factor gene LMX1B with autism. [PDF]

PLoS ONE, 2011
Multiple lines of evidence suggest a serotoninergic dysfunction in autism. The role of LMX1B in the development and maintenance of serotoninergic neurons is well known.
Ismail Thanseem, Kazuhiko Nakamura, Ayyappan Anitha, Shiro Suda, Kazuo Yamada, Yoshimi Iwayama, Tomoko Toyota, Masatsugu Tsujii, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Keiko Iwata, Toshiro Sugiyama, Takeo Yoshikawa, Norio Mori   +14 more
doaj   +5 more sources

Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons. [PDF]

PLoS ONE, 2015
Studying the development of mesodiencephalic dopaminergic (mdDA) neurons provides an important basis for better understanding dopamine-associated brain functions and disorders and is critical for establishing cell replacement therapy for Parkinson's ...
Orna Sherf, Limor Nashelsky Zolotov, Keren Liser, Hadas Tilleman, Vukasin M Jovanovic, Ksenija Zega, Marin M Jukic, Claude Brodski   +7 more
doaj   +8 more sources

Lmx1b Influences Correct Post-mitotic Coding of Mesodiencephalic Dopaminergic Neurons [PDF]

Frontiers in Molecular Neuroscience, 2019
The Lim Homeobox transcription factor 1 beta (LMX1b) has been identified as one of the transcription factors important for the development of mesodiencephalic dopaminergic (mdDA) neurons.
Iris Wever, Pablo Largo-Barrientos, Elisa J. Hoekstra, Marten P. Smidt   +3 more
doaj   +3 more sources

Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome

Nature Genetics, 1998
Dorsal-ventral limb patterning in vertebrates is thought to be controlled by the LIM-homeodomain protein Lmx1b which is expressed in a spatially and temporally restricted manner along the dorsal-ventral limb axis. Here we describe the phenotype resulting from targeted disruption of Lmx1b.
Chen H., Lun Y., Ovchinnikov D., Kokubo H., Oberg K.C., Pepicelli C.V., Gan L., Lee B., Johnson R.L.   +8 more
openaire   +6 more sources

Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. [PDF]

PLoS ONE, 2011
The transcription factor Lmx1b is essential for the differentiation and survival of central serotonergic (5-HTergic) neurons during embryonic development. However, the role of Lmx1b in adult 5-HTergic neurons is unknown.
Ning-Ning Song, Jian-Bo Xiu, Ying Huang, Jia-Yin Chen, Lei Zhang, Lise Gutknecht, Klaus Peter Lesch, He Li, Yu-Qiang Ding   +8 more
doaj   +3 more sources

Identification of limb-specific Lmx1b auto-regulatory modules with Nail-patella syndrome pathogenicity [PDF]

Nature Communications, 2021
Nail-patella syndrome (NPS) is characterized by nail dysplasia, absent/hypoplastic patellae, chronic kidney disease, and glaucoma and can be caused by haploinsufficiency of LMX1B; however, not all patients harbor pathogenic LMX1B mutations.
Endika Haro, Florence Petit, Charmaine U. Pira, Conor D. Spady, Sara Lucas-Toca, Lauren I. Yorozuya, Austin L. Gray, Fabienne Escande, Anne-Sophie Jourdain, Andy Nguyen, Florence Fellmann, Jean-Marc Good, Christine Francannet, Sylvie Manouvrier-Hanu, Marian A. Ros, Kerby C. Oberg   +15 more
doaj   +2 more sources

Identification and characterization of LMX1B target genes [PDF]

, 2016
Mutationen im LMX1B Gen sind mit einer autosomal-dominanten Erkrankung namens Nagel-Patella-Syndrom verbunden, die Gliedmaßen, Augen, Gehirn und Nieren beeinflusst. Hauptziele von LMX1B in den Nieren sind die Fussfortsätze und Schlitzmembran der Podozyten.
Stepanova, Natalya
openaire   +2 more sources

LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult Kidneys [PDF]

Journal of the American Society of Nephrology, 2013
Mutations of the LMX1B gene cause nail-patella syndrome, a rare autosomal-dominant disorder affecting the development of the limbs, eyes, brain, and kidneys. The characterization of conventional Lmx1b knockout mice has shown that LMX1B regulates the development of podocyte foot processes and slit diaphragms, but studies using podocyte-specific Lmx1b ...
Burghardt, T., Kastner, J., Suleiman, H., Rivera-Milla, E., Stepanova, N., Lottaz, C., Kubitza, M., Boeger, C., Schmidt, S., Gorski, M., de Vries, U., Schmidt, H., Hertting, I., Kopp, J., Rascle, A., Moser, M., Heid, I., Warth, R., Spang, R., Wegener, J., Mierke, C., Englert, C., Witzgall, R.   +22 more
openaire   +4 more sources

The lmx1b gene is pivotal in glomus development in Xenopus laevis [PDF]

Developmental Biology, 2008
We have previously shown that lmx1b, a LIM homeodomain protein, is expressed in the pronephric glomus. We now show temporal and spatial expression patterns of lmx1b and its potential binding partners in both dissected pronephric anlagen and in individual dissected components of stage 42 pronephroi.
Haldin, Caroline E., Massé, Karine L., Bhamra, Surinder, Simrick, Subreena, Kyuno, Jun-ichi, Jones, Elizabeth A.   +5 more
openaire   +3 more sources