Results 51 to 60 of about 3,237 (188)
Die Rolle von Lmx1b bei der Aufrechterhaltung der podozytären Struktur [PDF]
, 2013 Eine Beteiligung von LMX1B an Entwicklungsvorgängen ist unumstritten, gibt es doch zahlreiche fehlentwickelte Strukturen, die auf einen LMX1B-Defekt zurückzuführen sind. Wie diese Vorgänge allerdings ablaufen, ist noch weitgehend unerforscht.
Kastner, Jürgen
core +1 more source
eLife, 2022 Assembly of transcriptomes encoding unique neuronal identities requires selective accessibility of transcription factors to cis-regulatory sequences in nucleosome-embedded postmitotic chromatin.
Xinrui L Zhang +4 more
doaj +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
An investigation of genetic risk factors in primary open-angle glaucoma [PDF]
, 2009 Primary open-angle glaucoma (POAG) is a multifactorial disease with a strong genetic component. Notably however, few genes have been robustly associated with POAG in the general population.
Park, S.
core
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat +11 more
wiley +1 more source
Affinity purified Lmx1b-HIS proteins.
, 2013 (A) Lmx1b-HIS purified proteins from MN9D cells, by means of HIS tagged affinity purification via Ni-NTA agarose beads, followed by separation on silver-stained SDS gel. The left lane represents proteins purified from control transfected MN9D cells.
Marten P. Smidt (53462) +3 more
core +1 more source
Ectopic Wnt/beta-catenin signaling induces neurogenesis in the spinal cord and hindbrain floor plate. [PDF]
PLoS ONE, 2012 The most ventral structure of the developing neural tube, the floor plate (FP), differs in neurogenic capacity along the neuraxis. The FP is largely non-neurogenic at the hindbrain and spinal cord levels, but generates large numbers of dopamine (mDA ...
Milan Joksimovic +4 more
doaj +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
wiley +1 more source
Lmx1b is required at multiple stages to build expansive serotonergic axon architectures
eLife, 2019 Formation of long-range axons occurs over multiple stages of morphological maturation. However, the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development are unknown. Here, we addressed this question
Lauren J Donovan +7 more
doaj +1 more source
Advances in the genetics of refractive errors: Contributions from the CREAM consortium
Acta Ophthalmologica, Volume 104, Issue 3, Page e222-e231, May 2026.Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li +11 more
wiley +1 more source