Results 51 to 60 of about 2,585 (164)
Advanced Science, Volume 13, Issue 18, 27 March 2026.Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian +5 more
wiley +1 more source
LMX1B‐Regulated Nephrogenesis: A Role for Proteoglycans
The FASEB Journal, 2013 Lmx1b is a transcription factor necessary for kidney development. In humans, haploinsufficiency causes Nail Patella Syndrome frequently with chronic renal failure. In Lmx1b knockout mice, glomerular basement membrane formation is impaired, blocking filtration, urine production and long term survival.
Aldo Jhonathan Espinoza +3 more
openaire +1 more source
The Journal of Physiology, Volume 604, Issue 5, Page 2110-2130, 1 March 2026.Abstract figure legend During infection, prostaglandin E2 (PGE2) is produced and elicits warmth‐seeking behaviour and involuntary febrile responses by acting on prostaglandin EP3 receptors (EP3Rs) in two distinct brain sites. PGE2 acting on EP3Rs on neurons in the external lateral part of the lateral parabrachial nucleus (LPBel) augments cold sensory ...
Takaki Yahiro +2 more
wiley +1 more source
Integration of genomic and functional approaches reveals enhancers at LMX1A and LMX1B [PDF]
Molecular Genetics and Genomics, 2013 LMX1A and LMX1B encode two closely related members of the LIM homeobox family of transcription factors. These genes play significant, and frequently overlapping, roles in the development of many structures in the nervous system, including the cerebellum, hindbrain, spinal cord roof plate, sensory systems and dopaminergic midbrain neurons.
Grzegorz M, Burzynski +4 more
openaire +2 more sources
Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS
Advanced Science, Volume 13, Issue 10, 18 February 2026.This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu +14 more
wiley +1 more source
LMX1B mutation with residual transcriptional activity as a cause of isolated glomerulopathy [PDF]
Nephrology Dialysis Transplantation, 2013 Nail-patella syndrome (NPS) is a rare autosomal-dominant disorder caused by LMX1B mutation. In patients with the renal lesions typical of NPS without skeletal or nail findings, it is described as nail-patella-like renal disease (NPLRD). However, the pathogenesis of NPLRD is largely unknown.A 6-year-old girl with microscopic haematuria and mild ...
Tsuyoshi, Isojima +10 more
openaire +2 more sources
Polydopamine‐Based Antioxidant Countermeasures Against Spaceflight‐Induced Neurodegeneration
Small Science, Volume 6, Issue 1, January 2026.Polydopamine nanoparticles (PDNPs) protect neuron‐like cells from microgravity‐ and cosmic radiation‐induced oxidative stress. Through in‐flight and ground‐based experiments, it has been shown that PDNPs preserve neuronal and mitochondrial function, markedly mitigating transcriptional dysregulation caused by spaceflight.
Alessio Carmignani +10 more
wiley +1 more source
Nail-patella-like renal disease masquerading as Fabry disease on kidney biopsy: a case report
BMC Nephrology, 2020 Background Genetic changes in the LIM homeobox transcription factor 1 beta (LMX1B) have been associated with focal segmental glomerulosclerosis (FSGS) without the extra-renal or ultrastructural manifestations of Nail-patella syndrome (NPS) known as Nail ...
Filippo Pinto e Vairo +7 more
doaj +1 more source
A Novel CRB2 Mutation Associated With FSGS and ESRD in an Adult Patient
Case Reports in Nephrology, Volume 2026, Issue 1, 2026.Background Chronic kidney disease (CKD) is a major global health concern, with a substantial proportion of cases that remain of undetermined cause. Mutations in genes affecting podocyte structure and function, are increasingly recognized as causes of focal segmental glomerulosclerosis (FSGS), a common but highly nonspecific histological pattern of ...
Michele Marchini +3 more
wiley +1 more source
The lmx1b gene is pivotal in glomus development in Xenopus laevis
Developmental Biology, 2008 We have previously shown that lmx1b, a LIM homeodomain protein, is expressed in the pronephric glomus. We now show temporal and spatial expression patterns of lmx1b and its potential binding partners in both dissected pronephric anlagen and in individual dissected components of stage 42 pronephroi.
Haldin, Caroline E. +5 more
openaire +2 more sources