Results 71 to 80 of about 4,807 (209)

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

The Role of Lmx1a and Lmx1b in Regulating Mesencephalon Development and Dopamine Neuron Specification [PDF]

, 2010
One of the most challenging questions in developmental biology is how neurons are specified, acquire their distinct characteristics and find their correct innervations to form functional circuits.
Deng, Qiaolin
core  

En1 and Wnt signaling in midbrain dopaminergic neuronal development [PDF]

, 2011
Dopaminergic neurons of the ventral mesodiencephalon are affected in significant health disorders such as Parkinson's disease, schizophrenia, and addiction.
Maria TM Alves dos Santos, Marten P Smidt   +1 more
core   +1 more source

Polydopamine‐Based Antioxidant Countermeasures Against Spaceflight‐Induced Neurodegeneration

Small Science, Volume 6, Issue 1, January 2026.
Polydopamine nanoparticles (PDNPs) protect neuron‐like cells from microgravity‐ and cosmic radiation‐induced oxidative stress. Through in‐flight and ground‐based experiments, it has been shown that PDNPs preserve neuronal and mitochondrial function, markedly mitigating transcriptional dysregulation caused by spaceflight.
Alessio Carmignani, Attilio Marino, Matteo Battaglini, Melike Belenli Gümüş, Elisa Carrubba, Michele Balsamo, Giovanni Valentini, Gabriele Mascetti, Marco Vukich, Giada Graziana Genchi, Gianni Ciofani   +10 more
wiley   +1 more source

The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord [PDF]

, 2013
Dorsal horn neurons in the spinal cord integrate and relay sensory information to higher brain centers. These neurons are organized in specific laminae and different transcription factors are involved in their specification.
Bellocchio, Ben-Ari, Bermingham, Bouillet, Briscoe, Brown, Brown, Buckley, Burroughs-Garcia, Caspary, Chen, Cheng, Chiang, Chotteau-Lelièvre, Cui, Dickenson, Escurat, Fremeau, Ganguly, Glasgow, Goulding, Gowan, Graham, Gross, Guo, Hatcher, Helms, Honda, Irwin, John, Kaneko, Larsson, Le Mouellic, Lee, Leonardo, Lewis, Lin, Magin, Malcangio, Melzack, Müller, Nagy, Niss, Ozaki, Ramírez-Solis, Rebelo, Rexed, Rhinn, Rhinn, Rhinn, Rhinn, Robertson, Shamim, Sibilla, Simeone, Somogyi, Stein, Todd, Wassarman, Waters, Waters, White, Willis   +62 more
core   +3 more sources

Integration of genomic and functional approaches reveals enhancers at LMX1A and LMX1B [PDF]

Molecular Genetics and Genomics, 2013
LMX1A and LMX1B encode two closely related members of the LIM homeobox family of transcription factors. These genes play significant, and frequently overlapping, roles in the development of many structures in the nervous system, including the cerebellum, hindbrain, spinal cord roof plate, sensory systems and dopaminergic midbrain neurons.
Grzegorz M, Burzynski, Xylena, Reed, Samantha, Maragh, Takeshi, Matsui, Andrew S, McCallion   +4 more
openaire   +2 more sources

A Novel CRB2 Mutation Associated With FSGS and ESRD in an Adult Patient

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Background Chronic kidney disease (CKD) is a major global health concern, with a substantial proportion of cases that remain of undetermined cause. Mutations in genes affecting podocyte structure and function, are increasingly recognized as causes of focal segmental glomerulosclerosis (FSGS), a common but highly nonspecific histological pattern of ...
Michele Marchini, Sonila Mocka, Matteo Trezzi, Poorani Gurumallesh   +3 more
wiley   +1 more source

LMX1B mutation with residual transcriptional activity as a cause of isolated glomerulopathy [PDF]

Nephrology Dialysis Transplantation, 2013
Nail-patella syndrome (NPS) is a rare autosomal-dominant disorder caused by LMX1B mutation. In patients with the renal lesions typical of NPS without skeletal or nail findings, it is described as nail-patella-like renal disease (NPLRD). However, the pathogenesis of NPLRD is largely unknown.A 6-year-old girl with microscopic haematuria and mild ...
Tsuyoshi, Isojima, Yutaka, Harita, Masayuki, Furuyama, Noriko, Sugawara, Kiyonobu, Ishizuka, Shigeru, Horita, Yuko, Kajiho, Kenichiro, Miura, Takashi, Igarashi, Motoshi, Hattori, Sachiko, Kitanaka   +10 more
openaire   +2 more sources

Nail-patella-like renal disease masquerading as Fabry disease on kidney biopsy: a case report

BMC Nephrology, 2020
Background Genetic changes in the LIM homeobox transcription factor 1 beta (LMX1B) have been associated with focal segmental glomerulosclerosis (FSGS) without the extra-renal or ultrastructural manifestations of Nail-patella syndrome (NPS) known as Nail ...
Filippo Pinto e Vairo, Pavel N. Pichurin, Fernando C. Fervenza, Samih H. Nasr, Kevin Mills, Christopher T. Schmitz, Eric W. Klee, Sandra M. Herrmann   +7 more
doaj   +1 more source

The zebrafish eye—a paradigm for investigating human ocular genetics [PDF]

, 2016
Although human epidemiological and genetic studies are essential to elucidate the aetiology of normal and aberrant ocular development, animal models have provided us with an understanding of the pathogenesis of multiple developmental ocular malformations.
Moosajee, M, Richardson, R, Tracey-White, D, Webster, A   +3 more
core   +1 more source