Results 181 to 190 of about 4,716 (190)

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Nature Neuroscience, 2015
The role of developmental transcription factors in maintenance of neuronal properties and in disease remains poorly understood. Lmx1a and Lmx1b are key transcription factors required for the early specification of ventral midbrain dopamine (mDA) neurons.
Ariadna, Laguna, Nicoletta, Schintu, André, Nobre, Alexandra, Alvarsson, Nikolaos, Volakakis, Jesper Kjaer, Jacobsen, Marta, Gómez-Galán, Elena, Sopova, Eliza, Joodmardi, Takashi, Yoshitake, Qiaolin, Deng, Jan, Kehr, Johan, Ericson, Per, Svenningsson, Oleg, Shupliakov, Thomas, Perlmann   +15 more
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Digit tip regeneration: role of Lmx1b

2023
Trabajo presentado en ISRB Webinars, celebrado en modalidad virtual el 06 de diciembre de 2022.
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Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development

Development, 2002
The isthmus is the organizing center for the tectum and cerebellum. Fgf8 and Wnt1 are secreted molecules expressed around the isthmus. The function of Fgf8 has been well analyzed, and now accepted as the most important organizing signal. Involvement of Wnt1 in the isthmic organizing activity was suggested by analysis of Wnt1 knockout mice. But its role
Eiji, Matsunaga, Tatsuya, Katahira, Harukazu, Nakamura   +2 more
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Absence of digit tip regeneration in Lmx1b-deficient nailless digits suggests a role for Lmx1b distinct from patterning

2023
Trabajo presentado en el 19th International Congress of Developmental Biology, celebrado en Guia (Portugal) del 16 al 20 de octubre de 2022.
Castilla-Ibeas, Alejandro, Zdral, Sofía, Galán, Laura, Haro, Endika, Allou, Lila, Campa, Víctor M., Icardo, Jose M., Mundlos, Stefan, Oberg, Kerby C., Ros, María A.   +9 more
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Charakterisierung induzierbarer, podozytenspezifischer Lmx1b Knock-out Mäuse

2014
Das Nagel-Patella Syndrom (NPS) zeigt eine Inzidenz von etwa 1:50.000 und ist durch Nagel-, Knie-, Ellbogen- und Hüftfehlbildungen sowie durch eine Nieren- und Augenbeteiligung gekennzeichnet (Sweeney E et al., 2003). Prognostisch entscheidend für die Patienten ist jedoch das Ausmaß der Nierenbeteiligung.
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LMX1B and the Nail Patella Syndrome

2008
Abstract Nail patella syndrome (NPS) is a dominantly inherited skeletal malformation syndrome. Patients have characteristic features including nail and patella hypoplasia, elbow and knee deformities, nephropathy, and ocular defects. The condition is characterized by high penetrance, variable expressivity, and signi)cant intrafamilial ...
Roy Morello, Jennifer N Lennington,, Brendan Lee   +2 more
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Lmx1b transcriptional regulation in limb development

Peer ...
Zdral, Sofía, Mate, Irene, Castilla-Ibeas, Alejandro, Galán, Laura, Oberg, Kerby C., Ros, María A.   +5 more
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LMX1B and the Nail-Patella Syndrome

2016
Philippe M. Campeau, Nadejda A. Bespalova, Brendan H. Lee   +2 more
openaire   +1 more source

Gene symbol: LMX1B. Disease: Nail-patella syndrome.

Human genetics, 2008
Wei-De, Lin, Chih-Ping, Chen, Der-Yean, Wang, Fuu-Jen, Tsai   +3 more
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Lmx1a and Lmx1b driven programming of mesodiencephalic dopaminergic neurons

2012
The last few years, considerable research has been realized to discover the molecular make-up of mdDA neurons, in order to generate specific mdDA populations that can be used for stem cell based replacement-therapy in Parkinson's disease (PD). The challenge is to identify genetic programs that are responsible for the generation of different mdDA ...
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