Results 11 to 20 of about 4,772 (187)
Cell Reports, 2023 Summary: Mammalian digit tip regeneration is linked to the presence of nail tissue, but a nail-explicit model is missing. Here, we report that nail-less double-ventral digits of ΔLARM1/2 mutants that lack limb-specific Lmx1b enhancers fail to regenerate.
Alejandro Castilla-Ibeas +9 more
doaj +5 more sources
Association of transcription factor gene LMX1B with autism. [PDF]
PLoS ONE, 2011 Multiple lines of evidence suggest a serotoninergic dysfunction in autism. The role of LMX1B in the development and maintenance of serotoninergic neurons is well known.
Ismail Thanseem +14 more
doaj +4 more sources
Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons. [PDF]
PLoS ONE, 2015 Studying the development of mesodiencephalic dopaminergic (mdDA) neurons provides an important basis for better understanding dopamine-associated brain functions and disorders and is critical for establishing cell replacement therapy for Parkinson's ...
Orna Sherf +7 more
doaj +6 more sources
LMX1B is part of a transcriptional complex with PSPC1 and PSF. [PDF]
PLoS ONE, 2013 The LIM homeodomain transcription factor Lmx1b is essential for the development of the isthmic organizer and mesodiencephalic dopaminergic neurons. The uncoupling of Pitx3 and Th expression, in the Lmx1b null mutant, suggests that Lmx1b may act as a ...
Elisa J Hoekstra +3 more
doaj +6 more sources
LMX1B-associated gankyrin expression predicts poor prognosis in glioma patients [PDF]
Journal of International Medical Research, 2020 Objective To explore the potential of the transcription factor LMX1B and downstream gankyrin as prognostic biomarkers of glioma. Methods The expression levels of gankyrin and LMX1B were detected in 52 normal brain specimens and 339 glioma specimens ...
Xu Guo +4 more
doaj +3 more sources
Lmx1b Influences Correct Post-mitotic Coding of Mesodiencephalic Dopaminergic Neurons [PDF]
Frontiers in Molecular Neuroscience, 2019 The Lim Homeobox transcription factor 1 beta (LMX1b) has been identified as one of the transcription factors important for the development of mesodiencephalic dopaminergic (mdDA) neurons.
Iris Wever +3 more
doaj +5 more sources
Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice [PDF]
Disease Models & Mechanisms, 2021 Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals.
Nicholas G. Tolman +11 more
doaj +4 more sources
AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice. [PDF]
J Comp NeurolRetro‐orbital injection of AAV‐PHP.eB‐FLEX‐tdTomato into four different strains of Cre mice produced various and distinct patterns of transduction efficiency and tropism across brain regions and cell types. We found many target neurons expressing tdTomato in most but not all strains, along with a low level of nonspecific (Cre‐independent) expression ...
Zhu H, Geerling JC.
europepmc +2 more sources
Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer [PDF]
Development, 2005 The mesencephalic and metencephalic region (MMR) of the vertebrate central nervous system develops in response to signals produced by the isthmic organizer (IsO). We have previously reported that the LIM homeobox transcription factor Lmx1b is expressed within the chick IsO, where it is sufficient to maintain expression of the secreted factor wnt1.
F Patrick, O'Hara +5 more
+5 more sources
Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives. [PDF]
BioessaysBreathing is typically automatic, ensuring homeostasis, but it is also shaped by emotion, behavior, and volition. This review synthesizes our current understanding of the flexible neural mechanisms that enable multimodal control of breathing, emphasizing the role of pontomedullary circuits.
Baertsch NA +4 more
europepmc +2 more sources