Peptide–LNA oligonucleotide conjugates
Organic & Biomolecular Chemistry, 2013 Although peptide-oligonucleotide conjugates (POCs) are well-known for nucleic acids delivery and therapy, reports on internal attachment of peptides to oligonucleotides are limited in number. To develop a convenient route for preparation of internally labeled POCs with improved biomedical properties, peptides were introduced into oligonucleotides via a
Kira Astakhova +3 more
openalex +5 more sources
Investigation of the activity of phosphothioate and phosphothioate-LNA-modified oligonucleotides against HIV-1 [PDF]
Frontiers in MedicineThis study investigated the antiretroviral efficacy, toxicity profile, and cellular uptake of phosphothioate (PS) and PS/LNA-modified oligonucleotides within an in vitro HIV infection model.
Ludmila Gotfrid +5 more
doaj +2 more sources
Efficient and specific DNA-targeting using single-stranded LNA/MOE mixmers and chimeric Invader:XenoRNA probes. [PDF]
Org Biomol ChemEverly ME, Hrdlicka PJ.
europepmc +3 more sources
Electromagnetic Noise Characterization and Suppression in Low-Field MRI Systems. [PDF]
Magn Reson MedABSTRACT Purpose Our goal is to develop and validate a practical protocol that guides users in identifying and suppressing electromagnetic noise in low‐field MRI systems, enabling operation near the thermal noise limit. Methods We present a systematic, stepwise methodology that includes diagnostic measurements, hardware isolation strategies, and good ...
Guallart-Naval T, Algarín JM, Alonso J.
europepmc +2 more sources
A wideband noise-canceling CMOS LNA exploiting a transformer [PDF]
, 2006 A broadband LNA incorporating single-ended to differential conversion, has been successfully implemented using a noise-canceling technique and a single on-chip transformer. The LNA achieves a high voltage gain of 19dB, a wideband input match (2.5-4.0 GHz)
Blaakmeer, Stephan C. +3 more
core +5 more sources
Design of X-Band GaN LNA MMIC with Switched Impedance Network for Improved Noise Figure [PDF]
Journal of Electromagnetic Engineering and ScienceIn this work, an X-band gallium nitride (GaN) low-noise amplifier (LNA) monolithic microwave integrated circuit (MMIC) with a switched impedance network for improved noise performance is designed and fabricated using a 0.25 μm GaN WIN-semiconductor ...
Byeong-Uk Lee
doaj +1 more source
Rigorous elimination of fast stochastic variables from the linear noise approximation using projection operators [PDF]
, 2012 The linear noise approximation (LNA) offers a simple means by which one can study intrinsic noise in monostable biochemical networks. Using simple physical arguments, we have recently introduced the slow-scale LNA (ssLNA) which is a reduced version of ...
A. N. Tikhonov +9 more
core +2 more sources
W‐Band MMIC chipset in 0.1‐μm mHEMT technology
ETRI Journal, 2020 We developed a 0.1‐μm metamorphic high electron mobility transistor and fabricated a W‐band monolithic microwave integrated circuit chipset with our in‐house technology to verify the performance and usability of the developed technology.
Jong‐Min Lee +11 more
doaj +1 more source
Frontiers in Microbiology, 2023 Studies of high nucleic acid-content (HNA) and low nucleic acid-content (LNA) bacterial communities are updating our view of their distributions and taxonomic composition.
Wei Hu +4 more
doaj +1 more source
Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori [PDF]
, 2015 Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H.
Azevedo, Nuno F +13 more
core +6 more sources