Results 31 to 40 of about 23,328 (215)
Efficient reverse transcription using locked nucleic acid nucleotides towards the evolution of nuclease resistant RNA aptamers. [PDF]
PLoS ONE, 2012 BACKGROUND: Modified nucleotides are increasingly being utilized in the de novo selection of aptamers for enhancing their drug-like character and abolishing the need for time consuming trial-and-error based post-selection modifications.
Lucile Crouzier +5 more
doaj +1 more source
Advanced Science, EarlyView.This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng +7 more
wiley +1 more source
An 8-bit Digitally-controlled Low NF VGA for 5G Millimeter-wave Beamforming in 65 nm CMOS Technology
ENP Engineering Science JournalIn this paper, a linear-in-dB digitally controlled variable gain low-noise amplifier (D-VGLNA) designed in 65 nm CMOS process for the 5G mm-wave phase-array subsystem is presented.
Sid Ahmed Tedjini, Sonia Salhi
doaj +1 more source
The intratracheal administration of locked nucleic acid containing antisense oligonucleotides induced gene silencing and an immune-stimulatory effect in the murine lung. [PDF]
PLoS ONE, 2017 Locked nucleic acid containing antisense oligonucleotides (LNA-ASOs) have the potential to modulate the disease-related gene expression by the RNaseH-dependent degradation of mRNAs.
Yasunori Uemura +2 more
doaj +1 more source
Advanced Science, EarlyView.eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin +3 more
wiley +1 more source
Advanced Electronic Materials, EarlyView.In dynamic driving scenarios, the proposed approach ensures only temporally aligned sensor inputs to make driving decisions, preventing false activations. By enabling selective hardware‐level learning, it achieves fast, reliable responses under noisy conditions.
Kapil Bhardwaj +4 more
wiley +1 more source
Lateral Nasal Artery Perforator Flaps: Anatomic Study and Clinical Applications
Archives of Plastic Surgery, 2016 Background Previous studies have investigated facial artery perforators, but have reported inconsistent results regarding lateral nasal artery (LNA) perforators.
Giuseppe AG Lombardo +4 more
doaj +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT The United States (U.S.) faces challenges in achieving its ambitious net‐zero carbon emissions target by 2050, with current emissions having fallen by less than 1% in 2024. Despite an investment of $500 billion in low‐carbon resources while holding the second‐largest green technology patent portfolio globally, it is further imperative to ...
Md Zubair Ahmad +5 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2018 The successful development of high-affinity gapmer antisense oligonucleotide (ASO) therapeutics containing locked nucleic acid (LNA) or constrained ethyl (cEt) substitutions has been hampered by the risk of hepatotoxicity.
Andreas Dieckmann +7 more
doaj +1 more source
Spatio-Temporal Variations of High and Low Nucleic Acid Content Bacteria in an Exorheic River. [PDF]
PLoS ONE, 2016 Bacteria with high nucleic acid (HNA) and low nucleic acid (LNA) content are commonly observed in aquatic environments. To date, limited knowledge is available on their temporal and spatial variations in freshwater environments.
Jie Liu +5 more
doaj +1 more source