Results 51 to 60 of about 112,460 (239)

Efficient reverse transcription using locked nucleic acid nucleotides towards the evolution of nuclease resistant RNA aptamers. [PDF]

PLoS ONE, 2012
BACKGROUND: Modified nucleotides are increasingly being utilized in the de novo selection of aptamers for enhancing their drug-like character and abolishing the need for time consuming trial-and-error based post-selection modifications.
Lucile Crouzier, Camille Dubois, Stacey L Edwards, Lasse H Lauridsen, Jesper Wengel, Rakesh N Veedu   +5 more
doaj   +1 more source

Preparation and Study of Solid Lipid Nanoparticles Based on Curcumin, Resveratrol and Capsaicin Containing Linolenic Acid

Pharmaceutics, 2022
Linolenic acid (LNA) is the most highly consumed polyunsaturated fatty acid found in the human diet. It possesses anti-inflammatory effects and the ability to reverse skin-related disorders related to its deficiency.
Roberta Cassano, Simona Serini, Federica Curcio, Sonia Trombino, Gabriella Calviello   +4 more
doaj   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

SiGe HBT X-Band LNAs for Ultra-Low-Noise Cryogenic Receivers [PDF]

, 2008
We report results on the cryogenic operation of two different monolithic X-band silicon-germanium (SiGe) heterojunction bipolar transistor low noise amplifiers (LNAs) implemented in a commercially-available 130 nm SiGe BiCMOS platform.
Bardin, Joseph C., Cressler, John D., Kuo, Wei-Min Lance, Mani, Hamdi, Phillips, Stanley D., Thirivikraman, Tushar K., Weinreb, Sander, Yuan, Jiahui   +7 more
core   +1 more source

Antenna Effect in Halogen‐Containing ZnSm Coordination Compounds: Utilizing Colorimetry for a Room‐Temperature Tunable Ratiometric Molecular Thermometer

Advanced Science, EarlyView.
The ZnSm‐Cl dinuclear molecular complex was synthesized through a simple one‐pot method. ZnL and Sm3+ exhibit complementary temperature‐dependent emission As the temperature increases, a noticeable color difference of ZnSm‐Cl can be observed within the room temperature range of 253‐333 K.
Ye Xia, Yingshan Xue, Feng Pan, Ai Wang, Hong Huang, Zhenxing Li, Bing‐Wu Wang, Song Gao   +7 more
wiley   +1 more source

A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides

Molecular Therapy: Nucleic Acids, 2018
The successful development of high-affinity gapmer antisense oligonucleotide (ASO) therapeutics containing locked nucleic acid (LNA) or constrained ethyl (cEt) substitutions has been hampered by the risk of hepatotoxicity.
Andreas Dieckmann, Peter H. Hagedorn, Yvonne Burki, Christine Brügmann, Marco Berrera, Martin Ebeling, Thomas Singer, Franz Schuler   +7 more
doaj   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Lateral Nasal Artery Perforator Flaps: Anatomic Study and Clinical Applications

Archives of Plastic Surgery, 2016
Background Previous studies have investigated facial artery perforators, but have reported inconsistent results regarding lateral nasal artery (LNA) perforators.
Giuseppe AG Lombardo, Serena Tamburino, Luciano Tracia, Maria Stella Tarico, Rosario Emanuele Perrotta   +4 more
doaj   +1 more source

Chiral Analysis of Quenched Baryon Masses [PDF]

, 2002
We extend to quenched QCD an earlier investigation of the chiral structure of the masses of the nucleon and the delta in lattice simulations of full QCD. Even after including the meson-loop self-energies which give rise to the leading and next-to-leading
A. W. Thomas, A.W. Thomas, C. Bernard, C.W. Bernard, C.W. Bernard, D. B. Leinweber, D.B. Leinweber, D.B. Leinweber, D.B. Leinweber, D.B. Leinweber, D.B. Leinweber, D.B. Leinweber, D.B. Leinweber, D.B. Leinweber, E.J. Hackett-Jones, E.J. Hackett-Jones, G.V. Dunne, J. Gasser, J. Gasser, J.F. Donoghue, J.M. Zanotti, J.N. Labrenz, K. Kanaya, K.C. Bowler, M.J. Savage, M.N. Butler, P.A.M. Guichon, R. D. Young, R. Sommer, R.D. Young, R.G. Edwards, S. Aoki, S. Aoki, S. V. Wright, S.D. Bass, S.R. Sharpe, S.R. Sharpe, T. DeGrand, V. Bernard, W. Bardeen, W. Detmold, W. Detmold, W. Detmold, Y. Kuramashi   +43 more
core   +2 more sources

Emerging research directions in nanoparticle‐based foam control for bioprocessing: a bibliometric approach

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Overfoaming remains a critical challenge in industrial bioprocesses, compromising mass transfer, operational stability, and downstream efficiency in bioreactors and wastewater treatment systems. This study provides a bibliometric and scientometric assessment of nanoparticle‐enabled foam control to map technological trends and identify research
Antonio Átila Menezes Ferreira, John Hebert da Silva Felix, Thiago Queiroz da Silva, Larissa Oliveira Araújo, Maria Tayane Barroso dos Santos, Larysse Maria Santiago de Castro, José Cleiton Sousa dos Santos   +6 more
wiley   +1 more source