Results 51 to 60 of about 23,272 (196)
A Sub‐Microsecond Switch Enabling SWIFT 23Na Imaging at 10.5 T
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose To enable sodium SWIFT imaging, which is a zero‐echo time imaging technique, at ultra‐high magnetic fields through the development of custom electronics hardware, and to showcase this capability with in vivo imaging results. Methods The custom hardware developed consists of a high‐speed optical trigger with 10 ns resolution, an in‐bore
Russell L. Lagore +10 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2016 Locked nucleic acid (LNA) oligonucleotides have been successfully used to efficiently inhibit endogenous small noncoding RNAs in vitro and in vivo. We previously demonstrated that the direct miR-221 inhibition by the novel 13-mer LNA-i-miR-221 induces ...
Maria Eugenia Gallo Cantafio +9 more
doaj +1 more source
Predictive efficacy of low burden EGFR mutation detected by next-generation sequencing on response to EGFR tyrosine kinase inhibitors in non-small-cell lung carcinoma. [PDF]
PLoS ONE, 2013 Direct sequencing remains the most widely used method for the detection of epidermal growth factor receptor (EGFR) mutations in lung cancer; however, its relatively low sensitivity limits its clinical use.
Hye Sook Kim +17 more
doaj +1 more source
Muscle &Nerve, EarlyView.ABSTRACT Aims We report 5‐year results from a phase 1/2a study of delandistrogene moxeparvovec, a recombinant adeno‐associated virus serotype rh74 vector‐based gene therapy for Duchenne muscular dystrophy (DMD), with post hoc analyses contextualizing functional outcomes. Methods Four ambulatory patients with DMD (≥ 4–< 8 years at enrollment) entered an
Jerry R. Mendell +10 more
wiley +1 more source
VIEW, EarlyView.In this work, we develop submicron‐resolution mapping of intracellular lipid elements (SMILE) as an extraction‐free vibrational spectroscopic imaging platform based on hyperspectral stimulated Raman scattering microscopy with a spectral analysis pipeline for pixel‐resolved lipid profiling.
Yihui Zhou +10 more
wiley +1 more source
Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity
VIEW, EarlyView.Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin +3 more
wiley +1 more source
Journal of Vinyl and Additive Technology, EarlyView.The curing process of epoxidized soybean oil (ESO) is feasible through the incorporation of amino acids, generating materials with greater thermal stability and improved environmental friendliness. ABSTRACT In this study, the curing and thermal degradation kinetics of epoxidized soybean oil (ESO) were investigated using L‐aspartic acid (AA) and DL ...
Nicole P. Soares +6 more
wiley +1 more source
Localized Lna Cooling in Vacuum
, 2006 In the Square Kilometre Array (SKA) telescope [1], [2], the noise temperature of the first LNA must be reduced in order to reduce the necessary active area and the total system costs. Cooling the LNA locally would significantly decrease the noise figure but also the necessary power since not the whole system has to be cooled.
Schreuder, F., Bij de Vaate, J.-G.
openaire +3 more sources
Journal of Lipid Research, 2007 We quantified incorporation rates of plasma-derived α-linolenic acid (α-LNA, 18:3n-3) into “stable” liver lipids and the conversion rate of α-LNA to docosahexaenoic acid (DHA, 22:6n-3) in male rats fed, after weaning, an n-3 PUFA-adequate diet (4.6% α ...
Miki Igarashi +5 more
doaj +1 more source
International Journal of Urban and Regional Research, EarlyView.Abstract This article develops the concept of environmental statecraft to study changing urban environmental politics in China and beyond. Our review of existing conceptions reveals a growing need to account for temporal and geographical complexity. Neoliberal conceptions of eco‐state restructuring are increasingly strained by contemporary geopolitical
Handuo Deng, Fulong Wu, Fangzhu Zhang
wiley +1 more source