Results 61 to 70 of about 23,272 (196)

Peri‐operative management of diabetes mellitus: a multidisciplinary consensus statement from the Association of Anaesthetists and the Joint British Diabetes Societies for Inpatient Care group

Anaesthesia, EarlyView.
Summary Introduction Surgery in patients with diabetes mellitus is associated with increased morbidity and mortality compared with those who do not have diabetes mellitus. This is likely multifactorial and could be attributed to organisational issues; dysglycaemia; hospital‐acquired diabetic ketoacidosis; errors with insulin prescribing and ...
Nicholas A. Levy, Kariem El‐Boghdadly, Dileep N. Lobo, Daniel J. Stubbs, Parizad Avari, Donal Buggy, Claire Frank, Kim Howson, Jinty Moffett, Emma Morris, Omar G. Mustafa, Glynn Nash, Pádraig Ó Scanaill, Sarah Procter, Gerry Rayman, Kim Russon, Caroline Thomas, Sarah Tinsley, Allan Xu, Ketan Dhatariya   +19 more
wiley   +1 more source

First Detection of Outflowing Gas in the Outskirts of the Broad-line Region in 1H 0707−495

The Astronomical Journal
We use near-infrared spectroscopy covering simultaneously the zJHK bands to look for outflowing gas from the nuclear environment of 1H 0707−495 taking advantage that this region is dominated by low-ionization broad-line region lines, most of them ...
Alberto Rodríguez-Ardila, Marcos Antonio Fonseca-Faria, Denimara Dias dos Santos, Swayamtrupta Panda, Murilo Marinello   +4 more
doaj   +1 more source

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source

Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling

Molecular Therapy: Nucleic Acids, 2017
Antisense oligonucleotide (AON) therapeutics offer new avenues to pursue clinically relevant targets inaccessible with other technologies. Advances in improving AON affinity and stability by incorporation of high affinity nucleotides, such as locked ...
Annie Moisan, Marcel Gubler, Jitao David Zhang, Yann Tessier, Kamille Dumong Erichsen, Sabine Sewing, Régine Gérard, Blandine Avignon, Sylwia Huber, Fethallah Benmansour, Xing Chen, Roberto Villaseñor, Annamaria Braendli-Baiocco, Matthias Festag, Andreas Maunz, Thomas Singer, Franz Schuler, Adrian B. Roth   +17 more
doaj   +1 more source

Bile‐Derived Exosomal miR‐196a/‐196b as Diagnostic Biomarkers Associated With Tumor Progression in Biliary Tract Cancer

Cancer Science, EarlyView.
Bile‐derived exosomal miR‐196a and miR‐196b are identified as novel biomarkers for biliary tract cancer. Serum miR‐196a levels are significantly elevated in advanced disease with metastasis, while both miRNAs contribute to tumor progression by promoting cancer cell proliferation and invasion.
Naotaka Kugiyama, Katsuya Nagaoka, Takehisa Watanabe, Michihiro Yoshida, Tadashi Toyohara, Cheng Pan, Kenyu Hashimoto, Fumiya Otsuka, Shinya Ushijima, Yukiko Uramoto, Hajime Iwasaki, Motohiro Yoshinari, Shunpei Hashigo, Kazuki Hayashi, Itaru Naitoh, Fumihiro Okumura, Hiromu Kondo, Kaiki Anbe, Hiromitsu Hayashi, Yoshihiro Komohara, Yasuhito Tanaka   +20 more
wiley   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, EarlyView.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source

Evaluating the protection status and exposure to warming of Caribbean reefs with high functional potential

Conservation Biology, EarlyView.
Abstract Over the past decades, climate change has emerged as a major threat to global biodiversity, negatively affecting the integrity and functioning of ecosystems and the benefits they provide to people. To mitigate these impacts, it is essential to identify climate refugia that support the persistence of the structure and function of reef ...
Sara M. Melo‐Merino, Andrés Lira‐Noriega, Enrique Martínez‐Meyer, Héctor Reyes‐Bonilla, Lorenzo Álvarez‐Filip   +4 more
wiley   +1 more source

Targeting LDL Cholesterol With LNA

Molecular Therapy - Nucleic Acids, 2012
Cardiovascular disease is the number one cause of death in the industrialized world. Much of the morbidity and mortality from heart disease can be linked to elevated low-density lipoprotein (LDL) cholesterol, and one of the key genes that increases LDL cholesterol is Proprotein convertase subtilisin/kexin type 9 (PCSK9).
openaire   +3 more sources

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

High Performance Low Noise Amplifier for Operations in Lower ISM Band [PDF]

Journal of Electrical and Electronics Engineering, 2019
Increasing wireless standards pushes the limits on the nonlinearity of the receivers. The mobile devices, being battery operated forces the power constrains on the design of RF receivers.
MECWAN Akash, DEVAHSRAYEE N. M.
doaj