Results 171 to 180 of about 48,734 (209)

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, Volume 183, Issue 8, Page 1640-1652, April 2026.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

lncRNAs: a new generation of targets and biomarkers in thyroid cancer. [PDF]

Eur Thyroid J
Maturi R, Esposito M, Coppes RP, De Vita G.   +3 more
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Targeting lncRNA DSCAM-AS1 for disease diagnosis and therapy. [PDF]

Noncoding RNA Res
Zhou L, Jin Y, Li Z, Dong H, Jin Y.
europepmc   +1 more source

Circular RNA Vv‐circCOR27 modulates thermotolerance through attenuating VvHSP90.2b‐VvHsfA7a interaction in grapevine

New Phytologist, Volume 250, Issue 2, Page 988-1003, April 2026.
Summary Circular RNAs (circRNAs) are single‐stranded, covalently closed RNA molecules that arise from exon back‐splicing. The identification and function investigation of circRNAs have been comprehensively explored in plants, however, the regulatory mechanisms are largely unknown.
Yi Ren, Yuanyuan Xu, Moyang Liu, Lipeng Zhang, Yue Song, Junpeng Li, Jingjing Liu, Dongying Fan, Zhen Zhang, Juan He, Jiuyun Wu, Qian Zha, Zhen Gao, Zheng'an Yang, Chao Ma   +14 more
wiley   +1 more source

Non-coding RNAs in neurodegeneration: an axis-based, evidence-tiered mechanistic synthesis. [PDF]

Metabol Open
Ahim SS, Bandegi M, Ghanbarzadeh E, Heidarzadehpilehrood R.   +3 more
europepmc   +1 more source

From Single‐Cell Clusters to Causality: ITCH Engagement for CKD Uncovered by Integrative Analysis of MR and MAGMA

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
This graphical abstract illustrates an integrative analysis of single‐cell RNA‐seq data in CKD. DEGs were subsequently identified as candidate genes via Mendelian randomization analysis and combined with MAGMA analysis, ITCH was identified as a key gene.
Xia Zhang, Dongdong Zhang, Jiazhen Shang, Zhitao Zeng, Shouyu Chai, Xincong Lv, Zhimei Lv, Rong Wang   +7 more
wiley   +1 more source

Systematic Identification of the Functional lncRNAs During H7N9 Avian Influenza Virus Infection in Mice. [PDF]

Viruses
Wang G, Hu Z, Cai X, Hu S, Gu M, Wang X, Peng D, Hu J, Liu X.   +8 more
europepmc   +1 more source

Recent Advances in Chemical Probing Strategies for RNA Structure Determination In Vivo

Chemistry – A European Journal, Volume 32, Issue 12, 23 March 2026.
This Review illustrates how structural probes combined with advanced sequencing technologies are revolutionizing our ability to map RNA structures and interactions within living cells. It highlights the development of innovative strategies tailored to probe RNA structures in particular biological contexts.
Maryana Yarshova, Jieyu Zhao, Chun Kit Kwok   +2 more
wiley   +1 more source