Results 51 to 60 of about 285,592 (275)

DataSheet_1_Projection-Based Neighborhood Non-Negative Matrix Factorization for lncRNA-Protein Interaction Prediction.zip

, 2019
Many long ncRNAs (lncRNA) make their effort by interacting with the corresponding RNA-binding proteins, and identifying the interactions between lncRNAs and proteins is important to understand the functions of lncRNA. Compared with the time-consuming and
Tingting He (297525), Yingjun Ma (1962334), Xingpeng Jiang (135440)   +2 more
core   +1 more source

LncRNA-TBP mediates TATA-binding protein recruitment to regulate myogenesis and induce slow-twitch myofibers

Cell Communication and Signaling, 2023
Background Skeletal muscle is comprised of heterogeneous myofibers that differ in their physiological and metabolic parameters. Of these, slow-twitch (type I; oxidative) myofibers have more myoglobin, more mitochondria, and higher activity of oxidative ...
Manting Ma, Bolin Cai, Zhen Zhou, Shaofen Kong, Jing Zhang, Haiping Xu, Xiquan Zhang, Qinghua Nie   +7 more
doaj   +1 more source

Classification of protein interaction sentences via gaussian processes [PDF]

, 2009
The increase in the availability of protein interaction studies in textual format coupled with the demand for easier access to the key results has lead to a need for text mining solutions.
Polajnar, T., Rogers, S., Tamara Polajnar, Mark Girolami, Girolami, M., Simon Rogers   +5 more
core   +1 more source

Protein-protein interaction.

, 2022
STRING software depicts the protein-protein interaction network of XRCC2, XRCC3 and RAD51. The first ten proteins that primarily interacts with XRCC2, XRCC3 and RAD51 is highlighted.
Nageswara Rao Dunna (11985969), Taruna Rajagopal (11985957), Srikanth Talluri (442338), Krishna Kumar Rathnam (11985963), Sivaramakrishnan Venkatabalasubramanian (11985966), Arun Seshachalam (11985960)   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A machine learning framework that integrates multi-omics data predicts cancer-related LncRNAs

BMC Bioinformatics, 2021
Background LncRNAs (Long non-coding RNAs) are a type of non-coding RNA molecule with transcript length longer than 200 nucleotides. LncRNA has been novel candidate biomarkers in cancer diagnosis and prognosis.
Lin Yuan, Jing Zhao, Tao Sun, Zhen Shen
doaj   +1 more source

LncRNA–Protein Interactions: A Key to Deciphering LncRNA Mechanisms

Biomolecules
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in a multitude of biological processes. However, their functional basis, particularly structure-based functional characteristics, remains elusive. lncRNAs exert their influence primarily through intricate interactions with various cellular components.
Zuoneng Wang, Muhammad Aftab, Zigang Dong, Yanan Jiang, Kangdong Liu   +4 more
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

PLAIDOH: a novel method for functional prediction of long non-coding RNAs identifies cancer-specific LncRNA activities

BMC Genomics, 2019
Background Long non-coding RNAs (lncRNAs) exhibit remarkable cell-type specificity and disease association. LncRNA’s functional versatility includes epigenetic modification, nuclear domain organization, transcriptional control, regulation of RNA splicing
Sarah C. Pyfrom, Hong Luo, Jacqueline E. Payton   +2 more
doaj   +1 more source