A Survey of Current Resources to Study lncRNA-protein Interactions. [PDF]
Non-Coding RNA, 2021 Phenotypes are driven by regulated gene expression, which in turn are mediated by complex interactions between diverse biological molecules. Protein-DNA interactions such as histone and transcription factor binding are well studied, along with RNA-RNA interactions in short RNA silencing of genes. In contrast, lncRNA-protein interaction (LPI) mechanisms
Melcy Philip, Tyrone Chen, Sonika Tyagi
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Predicting lncRNA–Protein Interactions by Heterogenous Network Embedding [PDF]
Frontiers in Genetics, 2022 lncRNA–protein interactions play essential roles in a variety of cellular processes. However, the experimental methods for systematically mapping of lncRNA–protein interactions remain time-consuming and expensive. Therefore, it is urgent to develop reliable computational methods for predicting lncRNA–protein interactions.
Guoqing Zhao +4 more
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IRWNRLPI: Integrating Random Walk and Neighborhood Regularized Logistic Matrix Factorization for lncRNA-Protein Interaction Prediction. [PDF]
Front Genet, 2018 Zhao Q +5 more
europepmc +2 more sources
Function of lncRNAs and approaches to lncRNA-protein interactions [PDF]
Science China Life Sciences, 2013 Long non-coding RNAs (lncRNAs), which represent a new frontier in molecular biology, play important roles in regulating gene expression at epigenetic, transcriptional and post-transcriptional levels. More and more lncRNAs have been found to play important roles in normal cell physiological activities, and participate in the development of varieties of ...
Zhu, JuanJuan +3 more
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LncRNA expression profile in human malignant embryonic rhabdomyosarcoma cell line infected with Coxsackie virus group B type 5 [PDF]
Jichu yixue yu linchuang, 2022 Objective To explore the molecular mechanism of the interaction between Coxsackie virus group B type 5 (CVB5) and the host, The long non-coding RNA(lncRNA) expression profile in human malignant embryonic rhabdomyosarcoma cell line (RD) infected by CVB5 ...
TENG Pei-ying, LI Jing, SHI Yu-lu, YANG Fan, OU Xia, CHEN Wei
doaj +1 more source
Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferation
Life Science Alliance, 2021 The authors determined that HOTAIR specifically bind to YBX1 and promote its nuclear translocation, and then regulating cell proliferation by stimulating the PI3K/Akt and ERK/RSK signaling pathways. HOTAIR is a long noncoding RNA (lncRNA) which serves as
Siting Li +8 more
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LPI-NRLMF: lncRNA-protein interaction prediction by neighborhood regularized logistic matrix factorization. [PDF]
Oncotarget, 2017 LncRNA-protein interactions play important roles in many important cellular processes including signaling, transcriptional regulation, and even the generation and progression of complex diseases. However, experimental methods for determining proteins bound by a specific lncRNA remain expensive, difficult and time-consuming, and only a few theoretical ...
Liu H +6 more
europepmc +4 more sources
Fitting a geometric graph to a protein-protein interaction network [PDF]
, 2008 Finding a good network null model for protein-protein interaction (PPI) networks is a fundamental issue. Such a model would provide insights into the interplay between network structure and biological function as well as into evolution.
Higham, Desmond J. +2 more
core +4 more sources
LPI-CSFFR: Combining Serial Fusion with Feature Reuse for Predicting LncRNA-Protein Interactions [PDF]
Computational Biology and Chemistry, 2022 <p>Long non-coding RNAs (LncRNAs) play important roles in a series of life activities, and they function primarily with proteins. The wet experimental-based methods in lncRNA-protein interactions (lncRPIs) study are time-consuming. Therefore, in this study, we propose a reliable computational-based method called LPI-CSFFR using sequences ...
Xiaoqian Huang +5 more
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Revealing protein-lncRNA interaction [PDF]
, 2015 Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs are often able to bind a large number of different RNAs.
Helmer Citterich, Manuela +5 more
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