A Survey of Current Resources to Study lncRNA-protein Interactions. [PDF]
Non-Coding RNA, 2021 Phenotypes are driven by regulated gene expression, which in turn are mediated by complex interactions between diverse biological molecules. Protein-DNA interactions such as histone and transcription factor binding are well studied, along with RNA-RNA interactions in short RNA silencing of genes. In contrast, lncRNA-protein interaction (LPI) mechanisms
Melcy Philip, Tyrone Chen, Sonika Tyagi
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Predicting lncRNA–Protein Interactions by Heterogenous Network Embedding [PDF]
Frontiers in Genetics, 2022 lncRNA–protein interactions play essential roles in a variety of cellular processes. However, the experimental methods for systematically mapping of lncRNA–protein interactions remain time-consuming and expensive. Therefore, it is urgent to develop reliable computational methods for predicting lncRNA–protein interactions.
Guoqing Zhao +4 more
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IRWNRLPI: Integrating Random Walk and Neighborhood Regularized Logistic Matrix Factorization for lncRNA-Protein Interaction Prediction. [PDF]
Front Genet, 2018 Zhao Q +5 more
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Protocol for detecting lncRNA-protein interactions in vitro by tRSA RNA pull-down assay
STAR ProtocolsSummary: Long non-coding RNAs (lncRNAs) work together with diverse RNA-binding proteins (RBPs) to fulfill key regulations in important cellular functions.
Liyun Jiang +4 more
doaj +3 more sources
LncRNA expression profile in human malignant embryonic rhabdomyosarcoma cell line infected with Coxsackie virus group B type 5 [PDF]
Jichu yixue yu linchuang, 2022 Objective To explore the molecular mechanism of the interaction between Coxsackie virus group B type 5 (CVB5) and the host, The long non-coding RNA(lncRNA) expression profile in human malignant embryonic rhabdomyosarcoma cell line (RD) infected by CVB5 ...
TENG Pei-ying, LI Jing, SHI Yu-lu, YANG Fan, OU Xia, CHEN Wei
doaj +1 more source
Function of lncRNAs and approaches to lncRNA-protein interactions [PDF]
Science China Life Sciences, 2013 Long non-coding RNAs (lncRNAs), which represent a new frontier in molecular biology, play important roles in regulating gene expression at epigenetic, transcriptional and post-transcriptional levels. More and more lncRNAs have been found to play important roles in normal cell physiological activities, and participate in the development of varieties of ...
Zhu, JuanJuan +3 more
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Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferation
Life Science Alliance, 2021 The authors determined that HOTAIR specifically bind to YBX1 and promote its nuclear translocation, and then regulating cell proliferation by stimulating the PI3K/Akt and ERK/RSK signaling pathways. HOTAIR is a long noncoding RNA (lncRNA) which serves as
Siting Li +8 more
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The Challenges and Opportunities of lncRNAs in Ovarian Cancer Research and Clinical Use [PDF]
, 2020 [Abstract] Ovarian cancer is one of the most lethal gynecological malignancies worldwide because it tends to be detected late, when the disease has already spread, and prognosis is poor.
Barreiro-Alonso, Aida +6 more
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LPI-NRLMF: lncRNA-protein interaction prediction by neighborhood regularized logistic matrix factorization. [PDF]
Oncotarget, 2017 LncRNA-protein interactions play important roles in many important cellular processes including signaling, transcriptional regulation, and even the generation and progression of complex diseases. However, experimental methods for determining proteins bound by a specific lncRNA remain expensive, difficult and time-consuming, and only a few theoretical ...
Liu H +6 more
europepmc +4 more sources
Interaction and cross-talk between non-coding RNAs. [PDF]
, 2017 Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each ...
Dahiya, Rajvir +3 more
core +2 more sources