Results 121 to 130 of about 215,538 (386)

Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Communications Biology, 2020
Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles.
Joana Carlevaro-Fita, Andrés Lanzós, L. Feuerbach, Chen Hong, David Mas-Ponte, J. S. Pedersen, Federico Samirkumar B. Gary D. Jonathan Rameen Johanna Keit Abascal Amin Bader Barenboim Beroukhim Bertl Boroe, F. Abascal, S. Amin, Gary D Bader, J. Barenboim, R. Beroukhim, Johanna Bertl, Keith A. Boroevich, S. Brunak, P. Campbell, D. Chakravarty, Calvin Wing Yiu Chan, Ken Chen, J. Choi, J. Deu-Pons, P. Dhingra, K. Diamanti, L. Feuerbach, J. Fink, Nuno A. Fonseca, J. Frigola, C. Gambacorti-Passerini, D. W. Garsed, M. Gerstein, G. Getz, A. González-Pérez, Qianyun Guo, I. Gut, D. Haan, M. P. Hamilton, N. Haradhvala, A. Harmanci, M. Helmy, C. Herrmann, J. Hess, A. Hobolth, Ermin Hodzic, H. Hornshøj, Keren Isaev, J. Izarzugaza, Rory Johnson, Todd A. Johnson, Malene Juul, R. Juul, A. Kahles, A. Kahraman, Manolis Kellis, Ekta Khurana, Jaegil Kim, J. K. Kim, Youngwook Kim, J. Komorowski, J. Korbel, Sushant Kumar, Andrés Lanzós, E. Larsson, M. Lawrence, Donghoon Lee, K. Lehmann, Shantao Li, Xiaotong Li, Ziao Lin, E. M. Liu, L. Lochovsky, S. Lou, Tobias Madsen, K. Marchal, I. Martincorena, A. Martínez-Fundichely, Y. Maruvka, Patrick D. McGillivray, W. Meyerson, Ferran Muiños, L. Mularoni, H. Nakagawa, M. Nielsen, M. Paczkowska, Keunchil Park, Kiejung Park, O. Pich, T. Pons, Sergio Pulido-Tamayo, Benjamin J. Raphael, J. Reimand, I. Reyes-Salazar, M. Reyna, Esther Rheinbay, M. Rubin, C. Rubio-Perez, R. Sabarinathan, S. C. Sahinalp, G. Saksena, L. Salichos, C. Sander, S. Schumacher, M. Shackleton, Ofer Shapira, Ciyue Shen, Raunak Shrestha, S. Shuai, N. Sidiropoulos, L. Sieverling, Nasa Sinnott-Armstrong, Lincoln D. Stein, Joshua M. Stuart, D. Tamborero, G. Tiao, T. Tsunoda, Husen M. Umer, Liis Uusküla-Reimand, A. Valencia, M. Vázquez, L. Verbeke, C. Wadelius, Lina Wadi, Jiayin Wang, J. Warrell, Sebastian M. Waszak, Joachim Weischenfeldt, D. Wheeler, Guanming Wu, Jun Yu, Jing Zhang, Xuanping Zhang, Yan Zhang, Zhongming Zhao, L. Zou, C. von Mering, Rory Johnson   +134 more
semanticscholar   +1 more source

Snord15b Maintains Stemness of Intestinal Stem Cells via Enhancement of Alternative Splicing of Btrc Short Isoform for Suppression of β‐Catenin Ubiquitination

Advanced Science, EarlyView.
In intestinal stem cells (ISCs), Snord15b associates with Ilf2 to recruit splicing factors for alternative splicing of Btrc mRNA, leading to the generation of short Btrc. This short Btrc fails to form a functional E3 ubiquitin ligase complex for β‐catenin ubiquitination and degradation.
Yuwei Xu, Peikang Zhang, Zhen Xiong, Yufei Lan, Hui Guo, Runyuan Wu, Cunzhen Li, Hongzhe Fan, Ying Du, Xiaoxiao Zhu, Dongdong Fan, Zhonglong Wang, Yong Tian, Zusen Fan   +13 more
wiley   +1 more source

Challenges and perspectives for structural biology of lncRNAs—the example of the Xist lncRNA A-repeats [PDF]

Journal of Molecular Cell Biology, 2019
AbstractFollowing the discovery of numerous long non-coding RNA (lncRNA) transcripts in the human genome, their important roles in biology and human disease are emerging. Recent progress in experimental methods has enabled the identification of structural features of lncRNAs. However, determining high-resolution structures is challenging as lncRNAs are
Alisha N Jones, Michael Sattler
openaire   +3 more sources

ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1

Journal of physiology and biochemistry, 2019
N6-Methyladenosine (m6A) is the most common posttranscriptional modification of RNA and plays critical roles in cancer pathogenesis. However, the biological function of long noncoding RNA (lncRNA) methylation remains unclear.
Jun Zhang, Shuai Guo, H. Piao, Yue Wang, Yue Wu, Xiang-yu Meng, Dong Yang, Zhi-chao Zheng, Yan Zhao   +8 more
semanticscholar   +1 more source

LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis

Aging, 2020
The role of LncRNA ADAMTS9-AS2 in the regulation of chemoresistance of gastric cancer (GC) is largely unknown. Here we found that LncRNA ADAMTS9-AS2 was low-expressed in GC tissues and cells compared to their normal counterparts.
Nian-sheng Ren, Tao Jiang, Chengbo Wang, Shilin Xie, Yanwei Xing, D. Piao, Tiemin Zhang, Yuekun Zhu   +7 more
semanticscholar   +1 more source

Gene Editing of a Susceptibility LncRNA Enhances Broad‐Spectrum Disease Resistance in Rice without Developmental Trade‐Offs

Advanced Science, EarlyView.
Editing susceptibility lncRNAs offers a strategy to enhance disease resistance without yield loss. RESIS, a domestication‐acquired, pathogen‐induced lncRNA, promotes protein N‐terminal acetylation through its interaction with NatA complex. Knockout of RESIS increases translation and confers broad‐spectrum resistance to both fungal and bacterial ...
Wen‐long Zhao, Ye Cheng, Jia‐hui Huang, Jun‐jie Feng, Hui‐yin Pang, Yi‐chao Qin, Zheng‐tong Chen, Yu Cheng, Jian‐ping Lian, Yan‐fei Zhou, Rui‐rui He, Meng‐qi Lei, Zi‐qin Cao, Lu Yang, Chao Yuan, Jie Jiang, Yue‐qin Chen, Yu‐chan Zhang   +17 more
wiley   +1 more source

Fer-1 like family member 4 pseudogene

EXCLI Journal : Experimental and Clinical Sciences
Cutaneous melanoma is the deadliest form of skin cancer. Despite advancements in treatment, many patients still face poor outcomes. A deeper understanding of the mechanisms involved in melanoma pathogenesis is crucial for improving diagnosis and therapy.
Tomasz Kolenda, Kacper Guglas, Maciej Stasiak, Paulina Poter, Joanna Kozłowska-Masłoń, Piotr Białas, Joanna Sobocińska, Marlena Janiczek-Polewska, Patrycja Mantaj, Anna Paszkowska, Zefiryn Cybulski, Anna Teresiak, Urszula Kazimierczak, Anna Przybyła, Andrzej Mackiewicz, Jacek Mackiewicz   +15 more
doaj   +1 more source

Determination of antiviral action of long non-coding RNA loc107051710 during infectious bursal disease virus infection due to enhancement of interferon production

Virulence, 2020
The functions and profiles of lncRNAs during infectious bursal disease virus (IBDV) infection have not been determined, yet. The objectives of this study were to determine the antiviral action of loc107051710 lncRNA during IBDV infection by investigating
Xuewei Huang, Yigang Xu, Qingyu Lin, Weilong Guo, Dongfang Zhao, Chunmei Wang, Li Wang, Han Zhou, Yanping Jiang, Wen Cui, Xinyuan Qiao, Yijing Li, Guangpeng Ma, Lijie Tang   +13 more
doaj   +1 more source

EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs. [PDF]

, 2018
BackgroundPolycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems.
He, Yuan, Li, Lili, Tang, Lixu, Wang, Yan, Wang, Yibin, Wang, Zhihua, Xie, Yinping, Yu, Ling, Yu, Pengcheng, Zheng, Di   +9 more
core  

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

Advanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang, Chengming Gao, Haibei Li, Yuying Chen, Liting Yang, Qian Jin, Lan Feng, Xia Wang, Xinyi Liu, Hongxia Chen, Rong Ye, Yuanchao Xue, Huiyun Wang, Musheng Zeng, Ming Yang, Huaiqiang Ju, Chengzhi Gao, Guangming Zhou, Qi Zhang, Qian Zhang, Geng Qin, Yuanfeng Li, Yahui Wang, Aiqing Yang, Anfeng Si, Qingfeng Song, Fuchu He, Pengbo Cao, Gangqiao Zhou   +28 more
wiley   +1 more source