Results 111 to 120 of about 144,315 (291)
Advanced Science, EarlyView.In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying +16 more
wiley +1 more source
Epigenetics, 2018 Long noncoding RNAs (lncRNAs) are critical regulators of cell biology whose alteration can lead to the development of diseases such as cancer. The potential role of lncRNAs and their epigenetic regulation in response to platinum treatment are largely ...
Olga Vera +5 more
doaj +1 more source
Advanced Science, EarlyView.We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng +8 more
wiley +1 more source
Epigenetics, 2018 Infants born preterm are at increased risk of multiple morbidities and mortality. Why some women deliver preterm remains poorly understood. Prior studies have shown that cervical microRNA expression and DNA methylation are associated with the length of ...
Heather H. Burris +10 more
doaj +1 more source
Advanced Science, EarlyView.CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang +9 more
wiley +1 more source
Cancer Management and Research, 2020 Suzhen Yan,1,* Lutao Du,1,* Xiumei Jiang,2 Weili Duan,1 Juan Li,1 Yujiao Xie,1 Yao Zhan,1 Shujun Zhang,1 Lili Wang,2 Shuhai Li,3 Chuanxin Wang1,4 1Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong Province ...
Yan S +10 more
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The Regulatory Roles of Long-non-Coding RNAs in Chemotherapy-Resistant Metastatic Breast Cancer [PDF]
Journal of Advanced Biomedical Sciences, 2020 Currently, breast cancer is the most prevalent malignancy worldwide, with the largest prevalence and mortality among women. The invasion and metastasis are the main causes of death from malignancies. However, the main mechanism of invasion and metastasis
Saeid Ghorbian +2 more
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Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. [PDF]
, 2018 Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been found that some of the chromatin modulatory machinery essential for proper development plays a previously unappreciated role in the ...
McKinsey, Timothy A +2 more
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The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity
AGING MEDICINE, EarlyView.Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley +1 more source
مجله علمی دانشگاه علوم پزشکی کردستان, 2023 Background and Aim: Allergic rhinitis is the most common chronic inflammatory disorder of the nasal mucosa. Long non-coding RNAs (lncRNA) are a group of non-coding RNAs involved in the pathogenesis of various inflammatory diseases. This study intended to
Gelayol Asadi +7 more
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