Results 91 to 100 of about 144,315 (291)
Advanced Science, EarlyView.Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang +14 more
wiley +1 more source
Non-Coding RNA, 2020 Telomerase RNA contains a template for synthesizing telomeric DNA and has been proposed to act as a flexible scaffold for holoenzyme protein subunits in the RNP.
Evan P. Hass, David C. Zappulla
doaj +1 more source
Targeting of polycombs to DNA in EMT [PDF]
, 2017 We here describe the conceptual advance provided by the study by Battistelli and coworkers (PMID: 27452518), that shed light on a molecular mechanism of Polycomb targeting in the biological process known as Epithelial-to-Mesenchymal Transition (EMT ...
Battistelli, Cecilia +2 more
core +1 more source
Advanced Science, EarlyView.TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng +9 more
wiley +1 more source
Cancer Management and Research, 2020 Dongdong Zhang,1,* Xingdong Cai,2,* Songwang Cai,1,* Wenyou Chen,1 Chuang Hu1 1Department of Thoracic Surgery, The First Affiliated Hospital, Jinan University, Guangzhou 510632, People’s Republic of China; 2Department of Respiratory Medicine, The ...
Zhang D, Cai X, Cai S, Chen W, Hu C
doaj
Long Non-Coding RNA XIST Promotes Wilms Tumor Progression Through the miR-194-5p/YAP Axis
Cancer Management and Research, 2021 Xingyue He,1 Xin Luo,2 Junjun Dong,1 Xing Deng,1 Feng Liu,1,2 Guanghui Wei1,2 1Department of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key ...
He X +5 more
doaj
The non-coding RNA landscape of plasma cell dyscrasias [PDF]
, 2020 Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat.
Azab, Kareem A +3 more
core +1 more source
Epigenomes in Cardiovascular Disease. [PDF]
, 2018 If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA +4 more
core +1 more source
Advanced Science, EarlyView.Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng +14 more
wiley +1 more source
Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]
, 2015 BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M +5 more
core +2 more sources