Results 81 to 90 of about 144,315 (291)

LncRNAs in pancreatic cancer

Oncotarget, 2016
Pancreatic cancer (PC) is one of the most common causes of cancer-related death. The underlying mechanism of PC is not completely understood at present. Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation.
Huang, Xiaoyi, Zhi, Xiaosong, Gao, Yisha, Ta, Na, Jiang, Hui, Zheng, Jianming   +5 more
openaire   +3 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition [PDF]

, 2016
The transcription factor Snail is a master regulator of cellular identity and epithelial-to-mesenchymal transition (EMT) directly repressing a broad repertoire of epithelial genes.
A Kuzmichev, A Tramontano, AM Khalil, C Battistelli, C Battistelli, C Chu, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cifuentes-Rojas, C Davidovich, CA McHugh, CL Tien, E Bolotin, F Garibaldi, F J Gonzalez, G Deb, G Grassi, H Peinado, H Peinado, J Chen, J Yang, J Zhao, JA Simon, JL Rinn, JP Thiery, KD Nolan, L Amicone, L Amicone, L Grassi, L Li, L Santangelo, L Santangelo, M Colletti, M Courel, M Kretz, M Rodriguez, M Tripodi, M Yu, MA Nieto, MA Perez-Moreno, MC Tsai, OG McDonald, P Arnold, P Wongtrakoongate, Q Cao, R Cao, R Kogo, RA Gupta, RY Huang, S Fujii, S Javaid, S Kaneko, S Lamouille, TD Schmittgen, V de Nonno, Y Chen, Y Lin, Y Nie, Y Yonemitsu, YJ Geng, Z Hou, Z Yang, ZT Tong   +65 more
core   +2 more sources

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

HAND2-AS1 Inhibits Gastric Adenocarcinoma Cells Proliferation and Aerobic Glycolysis via miRNAs Sponge

Cancer Management and Research, 2020
Zhiyuan Xu,1,* Hang Lv,2,* Yiping Wang,2 Can Hu,3 Shangqi Chen,3 Yian Du,1 Chengwei Shi,3 Xiangdong Cheng1 1Department of Gastric Surgery, Institute of Cancer and Basic Medicine, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang ...
Xu Z, Lv H, Wang Y, Hu C, Chen S, Du Y, Shi C, Cheng X   +7 more
doaj  

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. [PDF]

, 2020
BackgroundLong non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy.
Akeson, Mark, Birk, Harjus S, Gupta, Nalin, He, Daniel, Hong, Sung Jun, Horlbeck, Max A, Jain, Miten, Koontz, Mark, Lien, Brian V, Lim, Daniel A, Liu, S John, Malatesta, Martina, Monje, Michelle, Olsen, Hugh E, Pedraza, Leslie, Raleigh, David R, Saha, Parna, Seo, Kyounghee, Thombare, Shivani S, Ullian, Erik M, Weissman, Jonathan S   +20 more
core   +1 more source

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. [PDF]

, 2016
Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which
Backofen, Rolf, Cao, Xuhong, Chinnaiyan, Arul M, Collins, Colin, Feng, Felix Y, Gawronski, Alexander, Han, Sumin, Hayes, Daniel F, Hosono, Yasuyuki, Iyer, Matthew K, Kregel, Steven, Ma, Teng, Malik, Rohit, Niknafs, Yashar S, Pierce, Lori J, Pitchiaya, Sethuramasundaram, Poliakov, Anton, Prensner, John R, Rae, James M, Sahinalp, Cenk S, Siebenaler, Ronald F, Singhal, Udit, Speers, Corey, Uhl, Michael, Wilder-Romans, Kari, Xiao, Lanbo, Zhang, Chao, Zhao, Shuang G   +27 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source