Results 61 to 70 of about 156,390 (266)

The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells [PDF]

, 2016
Growth arrest-specific 5 (GAS5) lncRNA promotes apoptosis, and its expression is down-regulated in breast cancer. GAS5 lncRNA is a decoy of glucocorticoid/related receptors; a stem-loop sequence constitutes the GAS5 hormone response element mimic (HREM),

core   +1 more source

modulation of lncRNA

, 2022
The gut-lung axis has been implicated as a potential therapeutic target in lung disorders. While increasing evidence suggests that gut microbiota plays a critical role in regulating host immunity and contributing to tuberculosis (TB) development and ...
Zixu Chen, Huixin Guo, Lei Liu, Lingming Chen, Fang Yang, Linna Liu, Yiwei Chen, Lin Zhou, Gucheng Zeng, Tao Lin, Hongbo Shen, Yi Yang, Liang Chen, Chunmin Zhang, Qiongdan Mai, Lingchan Zeng, Xinchun Chen, Zhiyi Zhang, Guoliang Zhang, Hongying Liao   +19 more
core   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in human aortic dissection

, 2021
Background Many studies on long chain non-coding RNAs (lncRNAs) are published in recent years. But the roles of lncRNAs in aortic dissection (AD) are still unclear and should be further examined.
Panpan Guo, Liu, Qingyang, Xiaotong Song, Zhang, Jian, Guo, Panpan, Han, Yanshuo, Hao Zhang, Tu, Simei, Simei Tu, Fanxing Yin, Zhang, Hao, Yin, Fanxing, Bian, Ce, Ce Bian, Chen Chen, Song, Xiaotong, Chen, Chen, Jian Zhang, Yanshuo Han, Qingyang Liu   +19 more
core   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, EarlyView.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Integrated Analysis of lncRNA–Mediated ceRNA Network in Lung Adenocarcinoma

Frontiers in Oncology, 2020
Background A growing body of evidence indicates that long non-coding RNAs (lncRNAs) can act as competitive endogenous RNAs (ceRNAs) to bind to microRNAs (miRNAs), thereby affecting and regulating the expression of target genes.
Xian-xian Wu, Zhi-lin Sui, Hongdian Zhang, Ying Wang, Zhentao Yu   +4 more
semanticscholar   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

MOESM7 of Prognosis of clear cell renal cell carcinoma (ccRCC) based on a six-lncRNA-based risk score: an investigation based on RNA-sequencing data

, 2019
Additional file 7: Fig. S2. Flowchart for lncRNA validation in clear cell renal cell carcinoma (ccRCC) based on Gene Expression Omnibus (GEO ...
Gang Chen (107840), Xiu-Yun Liang (5917442), Liang Liang (19309), Xu Zhu (424407), Hui-hua Lan (7306973), Jiang-hui Zeng (7306970), Wei Lu (3580)   +6 more
core   +1 more source