Results 41 to 50 of about 156,390 (266)
Oncogene, 2020 RNA methylation is an important epigenetic modification. Recent studies on RNA methylation mainly focus on the m6A modification of mRNA, but very little is known about the m5C modification.
Zhen Sun +8 more
semanticscholar +1 more source
Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders
Non-Coding RNA, 2021 Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain.
V. Aliperti, J. Skonieczna, A. Cerase
semanticscholar +1 more source
LncRNA-mRNA correlation network of respose to clubroot infection process.
, 2019 LncRNA-mRNA correlation network of respose to clubroot infection process.
Dandan Xi (8087903) +5 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
lncRNA-miRNA-mRNA interaction network in tomato.
, 2019 The sky-blue, red, and orange nodes denote lncRNAs, miRNAs, and genes, respectively. Each gray edge denotes a target relationship between a miRNA and a gene or lncRNA, hidden in the ceRNA network.
Zhao Yang (358244) +5 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
A noncoding RNA promotes glycolysis in cancer cells by forming complexes with glycolytic enzymes in the cytoplasm [PDF]
, 2023 openA partire dalla scoperta dell’importanza delle sequenze contenute in quello che veniva definito “DNA spazzatura”, la ricerca ha fatto passi da giganti nello studio della porzione di genoma non codificante.
XODO, ELENA
core
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Local regulation of gene expression by lncRNA promoters, transcription, and splicing
Nature, 2016 Mammalian genomes are pervasively transcribed to produce thousands of long non-coding RNAs (lncRNAs). A few of these lncRNAs have been shown to recruit regulatory complexes through RNA–protein interactions to influence the expression of nearby genes, and
J. Engreitz +8 more
semanticscholar +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source