Results 31 to 40 of about 144,315 (291)

The pan-cancer lncRNA MILIP links c-Myc to p53 repression

Molecular & Cellular Oncology, 2021
We have recently identified the MYC proto-oncogene, bHLH transcription factor (MYC, best known as c-Myc)-responsive pan-cancer lncRNA c-Myc-Inducible Long noncoding RNA Inactivating P53 (MILIP) as an oncogenic driver.
Yu Chen Feng, Xiao Hong Zhao, Liu Teng, Rick F. Thorne, Lei Jin, Xu Dong Zhang   +5 more
doaj   +1 more source

Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer [PDF]

, 2018
Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer.
Fatica, Alessandro, Morlando, Mariangela
core   +2 more sources

Epithelial-mesenchymal transition-related genes in coronary artery disease

Open Medicine, 2022
Epithelial-mesenchymal transition (EMT) is critical in the development of coronary artery disease (CAD). However, landscapes of EMT-related genes have not been fully established in CAD.
Xu Xiang, Zou Renchao, Liu Xiaoyong, Liu Jia, Su Qianqian   +4 more
doaj   +1 more source

The Landscape of Long Non-Coding RNA Dysregulation and Clinical Relevance in Muscle Invasive Bladder Urothelial Carcinoma. [PDF]

, 2019
Bladder cancer is one of the most common cancers in the United States, but few advancements in treatment options have occurred in the past few decades.
Chang, Eric Y, Chu, Megan, High, Rachel A, Li, Wei Tse, Ongkeko, Weg M, Shen, Haotian, Wang-Rodriguez, Jessica, Wong, Lindsay M   +7 more
core   +1 more source

LncRNAs in Stem Cells [PDF]

Stem Cells International, 2016
Noncoding RNAs are critical regulatory factors in essentially all forms of life. Stem cells occupy a special position in cell biology and Biomedicine, and emerging results show that multiple ncRNAs play essential roles in stem cells. We discuss some of the known ncRNAs in stem cells such as embryonic stem cells, induced pluripotent stem cells ...
Shanshan Hu, Ge Shan
openaire   +3 more sources

Long Non-Coding RNA MALAT1 Gene Polymorphism is Associated with Disease-Free Survival in Bladder Cancer Patients

Galician Medical Journal, 2020
The objective of the research was to study the possible association between MALAT1 gene rs3200401 polymorphism and the survival of patients with bladder cancer and clinicopathological characteristics in bladder cancer. Materials and Methods. The venous
Andrii Volkogon, Olena Kolnoguz, Viktoriia Harbuzova, Alexander Ataman   +3 more
doaj   +1 more source

Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. [PDF]

, 2017
Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, and thus may mediate oncogenic or tumor suppressing effects, as well as be a new class of cancer therapeutic targets. We performed high-throughput sequencing of RNA
Ai, B, Bai, X-F, Cao, H-H, Feng, C-C, He, J-Z, Huang, G-W, Koeffler, HP, Lei, F, Li, C-Q, Li, E-M, Li, M, Li, S, Li, X, Li, X-C, Liao, L-D, Lin, D-C, Liu, Y-J, Shen, J-H, Tang, Z-D, Wang, L-D, Wang, M-R, Wang, Q-Y, Wang, S-H, Wu, B-L, Wu, J-Y, Wu, Z-Y, Xu, L-Y, Xu, Y-J, Xue, Y-J, Zhang, J, Zhao, J-M, Zheng, C-P, Zhu, Y   +32 more
core   +1 more source

Construction and analysis of lncRNA-lncRNA synergistic networks to reveal clinically relevant lncRNAs in cancer

Oncotarget, 2015
Long non-coding RNAs (lncRNAs) play key roles in diverse biological processes. Moreover, the development and progression of cancer often involves the combined actions of several lncRNAs. Here we propose a multi-step method for constructing lncRNA-lncRNA functional synergistic networks (LFSNs) through co-regulation of functional modules having three ...
Yongsheng, Li, Juan, Chen, Jinwen, Zhang, Zishan, Wang, Tingting, Shao, Chunjie, Jiang, Juan, Xu, Xia, Li   +7 more
openaire   +3 more sources

Determination of antiviral action of long non-coding RNA loc107051710 during infectious bursal disease virus infection due to enhancement of interferon production

Virulence, 2020
The functions and profiles of lncRNAs during infectious bursal disease virus (IBDV) infection have not been determined, yet. The objectives of this study were to determine the antiviral action of loc107051710 lncRNA during IBDV infection by investigating
Xuewei Huang, Yigang Xu, Qingyu Lin, Weilong Guo, Dongfang Zhao, Chunmei Wang, Li Wang, Han Zhou, Yanping Jiang, Wen Cui, Xinyuan Qiao, Yijing Li, Guangpeng Ma, Lijie Tang   +13 more
doaj   +1 more source

The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter. [PDF]

, 2019
A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying and eradicating persistent reservoirs of replication-competent provirus.
Chang, Kungyen, Chao, Ti-Chun, Karris, Maile Ann Young, Kaul, Marcus, Li, Zhonghan, Qin, Yue, Rana, Tariq M, Sanchez, Ana, Singh, Gatikrushna, Tiwari, Shashi Kant, Yau, Edwin, Zhang, Qiong   +11 more
core   +1 more source