Results 141 to 150 of about 103,530 (319)
Exploratory Bioinformatics Study of lncRNAs in Alzheimer’s Disease mRNA Sequences with Application to Drug Development [PDF]
, 2013 Todd Holden +8 more
openalex +1 more source
BMC CancerAbstractLong noncoding RNAs (lncRNAs) are crucial regulators of biological processes such as transcription interference and activation, chromatin remodeling, and mRNA translation. Uncontrolled gene expression could result from various epigenetic modifiers, like lncRNAs.
Neveen A. Hussein +4 more
openaire +3 more sources
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Background: This study aims to identify genes with a high likelihood of genetic variation, significant expression differences, and prognostic implications in colorectal cancer (CRC) patients. The research also seeks to investigate the role and mechanisms of key genes in CRC through the analysis of health information data and a combination of ...
Kaobin Ouyang +3 more
wiley +1 more source
New insight into the role of long non-coding RNAs in the pathogenesis of preeclampsia
Hypertension in Pregnancy, 2019 Objective:Dysregulation of lncRNAs and the absence of coordination between them could affect the normal placentation, uteroplacental circulation, and endothelial cell function. All these misfunctions can finally lead to preeclampsia.
Mohammad-Taher Moradi +2 more
doaj +1 more source
Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia
BioEssays, EarlyView.Enhancers are key regulatory elements that are conceptually conserved from bacteria to humans. Enhancer dysregulation is common in cancers, including leukemia. We argue that highly specific protein–protein interactions, including transcription factors, mediate enhancer‐promoter proximity to allow enhancer‐bound factors to directly act on RNA polymerase
Nicholas T. Crump, Thomas A. Milne
wiley +1 more source
Thoracic Cancer, Volume 13, Issue 23, Page 3341-3352, December 2022., 2022 A multiphase, case–control study was conducted among 140 ESCC patients and 140 healthy controls (a). Microarray screening was performed to acquire differentially expressed exosomal lncRNAs in the discovery phase. Joint microarray results from serum and tissue samples determined the candidate lncRNAs (b). A diagnostic model Index I was constructed based
Kai Xie +11 more
wiley +1 more source
Clinical and Experimental Obstetrics & GynecologyBackground: Cervical cancer, a malignancy of gynecological origin, typically necessitates a therapeutic approach combining surgery and chemoradiotherapy as the primary intervention.
Jie Zhang, Qiong Xia, Qinghua Zhang
doaj +1 more source
Identification and characterization of unique to human regulatory sequences in embryonic stem cells reveal associations with transposable elements, distal enhancers, non-coding RNA, and DNA methylation-driven mechanisms of genome editing [PDF]
arXiv, 2014 Despite significant progress in structural and functional characterization of human genome, understanding of mechanisms underlying the genetic basis of human phenotypic uniqueness remains limited. We report that non-randomly distributed transposable element-derived sequences, most notably HERV-H/LTR7 and L1HS, are associated with creation of 99.8 ...
arxiv
The contribution of extracellular RNA and its derived biomaterials in disease management
BMEMat, EarlyView.The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei +8 more
wiley +1 more source
Platelet lncRNA as a biomarker for early screening of lung adenocarcinoma: a preliminary study
Zhongguo shuxue zazhiObjective To explore the diagnostic value of platelet long non-coding RNA (lncRNA) as a biomarker for early screening of lung adenocarcinoma (LUAD).
Bowen XIONG +3 more
doaj +1 more source