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Characterizing miRNA–lncRNA Interplay
2021Long noncoding RNAs (lncRNAs) are noncoding transcripts, usually longer than 200 nt, that constitute one of the largest and significantly heterogeneous RNA families. The annotation of lncRNAs and the characterization of their function is a constantly evolving field. LncRNA interplay with microRNAs (miRNAs) is thoroughly studied in several physiological
Dimitra, Karagkouni +3 more
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2021
Although the great majority of cancers share a defined group of hallmarks that is responsible for the uncontrolled growth of particular cell types, it is today clear that under the name of cancer we refer to hundreds of different diseases. Furthermore, each of these diseases has an intrinsic variability due to the genetic background in which it ...
Iaccarino, Ingram, Klapper, Wolfram
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Although the great majority of cancers share a defined group of hallmarks that is responsible for the uncontrolled growth of particular cell types, it is today clear that under the name of cancer we refer to hundreds of different diseases. Furthermore, each of these diseases has an intrinsic variability due to the genetic background in which it ...
Iaccarino, Ingram, Klapper, Wolfram
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LncRNAs and Available Databases
2021Long noncoding RNAs (lncRNAs) are involved in many regulatory mechanisms in practically every step of the RNA cycle, from transcription to RNA stability and translation. They are a highly heterogeneous class of molecules in terms of site of production, interaction networks, and functions. More and more databases are available on the web with the aim to
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WIREs RNA, 2016
The diversity of long non‐coding RNAs (lncRNAs) in the human transcriptome is in stark contrast to the sparse exploration of their functions concomitant with their conservation and evolution. The pervasive transcription of the largely non‐coding human genome makes the evolutionary age and conservation patterns of lncRNAs to a topic of interest.
Anne Nitsche, Peter F. Stadler
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The diversity of long non‐coding RNAs (lncRNAs) in the human transcriptome is in stark contrast to the sparse exploration of their functions concomitant with their conservation and evolution. The pervasive transcription of the largely non‐coding human genome makes the evolutionary age and conservation patterns of lncRNAs to a topic of interest.
Anne Nitsche, Peter F. Stadler
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Analyzing MiRNA–LncRNA Interactions
2016Long noncoding RNAs (lncRNAs) are noncoding transcripts usually longer than 200 nts that have recently emerged as one of the largest and significantly diverse RNA families. The biological role and functions of lncRNAs are still mostly uncharacterized. Their target-mimetic, sponge/decoy function on microRNAs was recently uncovered. miRNAs are a class of
Maria D, Paraskevopoulou +1 more
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LncRNAs and Cardiovascular Disease
2022A novel class of RNA molecule emerged from human transcriptome sequencing studies termed long non-coding RNAs. These RNA molecules differ from other classes of non-coding RNAs such as microRNAs in their sizes, sequence motifs and structures. Studies have demonstrated that long non-coding RNAs play a prominent role in the development and progression of ...
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2015
All living organisms sense and respond to harmful changes in their intracellular and extracellular environment through complex signaling pathways that lead to changes in gene expression and cellular function in order to maintain homeostasis. Long non-coding RNAs (lncRNAs), a large and heterogeneous group of functional RNAs, play important roles in ...
Saba, Valadkhan +1 more
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All living organisms sense and respond to harmful changes in their intracellular and extracellular environment through complex signaling pathways that lead to changes in gene expression and cellular function in order to maintain homeostasis. Long non-coding RNAs (lncRNAs), a large and heterogeneous group of functional RNAs, play important roles in ...
Saba, Valadkhan +1 more
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Clinica Chimica Acta, 2019
Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this
Jin-yan Wang, Ai-qing Lu, Li-juan Chen
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Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this
Jin-yan Wang, Ai-qing Lu, Li-juan Chen
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LncRNA Cancer Pharmacogenomics
2019Datasets and scripts associated with "Discovering long noncoding RNA predictors of anticancer drug sensitivity beyond protein-coding genes". Nath et al.
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LncRNA 1600012P17Rik is a mouse placenta-specific lncRNA
Placenta, 2019Junxiao Wang +3 more
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