Results 81 to 90 of about 1,670,871 (318)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A global model-agnostic rule-based XAI method based on Parameterized Event Primitives for time series classifiers

Frontiers in Artificial Intelligence
Time series classification is a challenging research area where machine learning and deep learning techniques have shown remarkable performance. However, often, these are seen as black boxes due to their minimal interpretability.
Ephrem Tibebe Mekonnen, Ephrem Tibebe Mekonnen, Luca Longo, Luca Longo, Pierpaolo Dondio   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A dynamics of the trainings loadings of highly skilled shooters is from a bow in precompetytion middle cycle [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2010
Quantity indicators of shots of sportsmen in building blocks of a mesocycle are defined. The qualifying determined dynamic of volumes of training loads of sportsmen fixed.
Briskin Yu.A., Pitуn M.P., Antonov S.V.
doaj  

Mechanical properties of diamond lattice Ti–6Al–4V structures produced by laser powder bed fusion: On the effect of the load direction

, 2020
Antonio Cutolo, Bert Engelen, Wim Desmet, Brecht Van Hooreweder   +3 more
openalex   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Dynamic stress accumulation effects on soil strength under cyclic loading

, 2022
Dengheng Zheng, Liansheng Tang, Yuxi Wang, Yin‐Lei Sun   +3 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Bacterial load of cockroaches in relation to urban environment [PDF]

, 1993
C. Rivault, Ann Cloarec, Annie Le Guyader   +2 more
openalex   +1 more source

Devising a method for balancing the load on a territorially distributed foggy environment

, 2023
Nina Kuchuk, Oleksandr Mozhaiev, Serhii Semenov, Andrii Haichenko, Heorhii Kuchuk, Serhii Tiulieniev, Mykhailo Mozhaiev, Viacheslav Davydov, Оксана Брусакова, Yurii Gnusov   +9 more
openalex   +2 more sources