Results 71 to 80 of about 2,022,327 (302)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Scanning of Power Deformation of Tyre Surface by Tactile Piesoresistive sensors

Advances in Electrical and Electronic Engineering, 2004
Our work describes a static non-destructive method of measuring the contact pressures of tyres. The distribution of contact pressures during the contact of the tyre with a solid base represents one of the indicators we use.
Ferdinand Hurta
doaj  

Segmental External Load in Linear Running in Elite Futsal Players: A Multifactorial and Individual Variability Analysis Using Linear Mixed Models

Sports
Limited evidence exists on how segmental external load is distributed during linear running and how it varies with speed, training intensity, and individual differences.
Diego Hernán Villarejo-García, Carlos Navarro-Martínez, José Pino-Ortega   +2 more
doaj   +1 more source

Online Power-Aware Deployment and Load Distribution Optimization for Application Server Clusters

IEEE Access, 2019
The energy conservation of application server clusters is a pressing problem. In this paper, we propose an online power-aware deployment and load distribution optimization strategy for application server clusters, whose objective is to minimize the ...
Zhi Xiong, Yu Cheng, Lingru Cai, Weihong Cai   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

An experimental investigation of the load distribution of splined joints under gear loading conditions

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017
Splined joints are commonly used to transmit rotary motion from a shaft to machine elements such as gears. While computationally efficient spline load distribution models have recently been proposed, there is no validated load distribution model of a ...
Michael BENATAR, David TALBOT, Ahmet KAHRAMAN   +2 more
doaj   +1 more source

LOAD DISTRIBUTION AND RESOURCE SHARING [PDF]

This paper will discuss about the system structure and system design philosophy for the large scale control systems. The design philosophy, the main theme of this article, is "load distribution and resource sharing", but also the following items will be ...
Gheorghe Petrescu, Vasile Lungu
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Research on Load Distribution and Fatigue Life Under Elliptical Deformation of Four-Point Contact Slewing Bearing Rings for Excavators

Lubricants
Excavators are critical equipment in mining, construction, and other fields. The four-point contact slewing bearings used in their slewing mechanisms operate under harsh conditions such as heavy loads and impacts. Furthermore, the bearing rings are prone
Haisheng Yang, Run Zhang, Jiahang Zhang, Zhanwang Shi, Yingbin Wei   +4 more
doaj   +1 more source

Load Distribution of Semi-Central Evaporative Cooling Air-Conditioning System Based on the TRNSYS Platform

Energies, 2018
Evaporative cooling is a green, energy-efficient cooling technology adopted in hot and dry regions, which has wider application in the field of air-conditioning systems.
Ji Li, Yuanwei Liu, Ruixue Zhang, Zhijian Liu, Wei Xu, Biao Qiao, Xiaomei Feng   +6 more
doaj   +1 more source