Results 111 to 120 of about 8,651,646 (342)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

On the Deformation of a Hyperelastic Tube Due to Steady Viscous Flow Within

, 2019
In this chapter, we analyze the steady-state microscale fluid--structure interaction (FSI) between a generalized Newtonian fluid and a hyperelastic tube.
A Lazopoulos, A Lazopoulos, A. I. Lurie, AH Shapiro, AK Abramian, AV Porubov, CL Dym, DA Indeitsev, F Gay-Balmaz, H Kraus, H Moon, IS Liu, J Bonet, JB Grotberg, LA Mihai, M Heil, MA Hussain, MK Raj, N. I. Muskhelishvili, NJ Wagner, RB Bird, RJ Whittaker, RL Bisplinghoff, Ronald L. Panton, RW Ogden, S Chien, S Čanić, SB Elbaz, SB Elbaz, Vishal Anand, Wilhelm Flügge, Yavuz Başar, Yuan-Cheng Fung   +32 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Faz Kaydırıcı Transformatörlerin Dinamik Gerilim Kararlılığına Etkileri

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2018
Günümüzde elektrik enerjisine olantalebin sürekli artması ve gelişen teknoloji ile birlikte güç sistemindeyapısal değişiklikler olmaktadır. Ayrıca güç sistemleri üzerinde sürekli değişikliklerolmaktadır.
Salih Tosun, Ali Öztürk
doaj  

A study of the effects of varying the established operating and maintenance procedures of the EASL facility [PDF]

Microbial load caused by stopping laminar flow in Experimental Assembly and Sterilization Laboratory ...
Hajema, E. M.
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Robust and dynamic transactive energy system using Tsypkin–Polyak theorem

IET Smart Grid, 2018
In this study, a robust and dynamic transactive energy system in smart grid (SG) environment is proposed based on the Tsypkin–Polyak theorem. A key factor of the proposed system is to consider the uncertainties in electrical grid parameters.
Mohammad Rayati, Sanaz Amirzadeh Goghari, Zahra Nasiri Gheidari, Ali Mohammad Ranjbar   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Reducing voltage fluctuations using DSTATCOMs and reactive power of PV inverters in a medium voltage distribution system

The Journal of Engineering, 2019
This paper proposes local reactive power control to mitigate the voltage fluctuation in medium-voltage systems using DSTATCOMs and photovoltaic (PV) inverters.
Duong Quoc Hung, Yateendra Mishra, Geoffrey Walker   +2 more
doaj   +1 more source

Estimating turbine limit load [PDF]

A method for estimating turbine limit-load pressure ratio from turbine map information is presented and demonstrated. It is based on a mean line analysis at the last-rotor exit.
Glassman, Arthur J.
core   +1 more source