Results 81 to 90 of about 367,594 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition. [PDF]

, 2018
Candidate pro-cognitive drugs for schizophrenia targeting several neurochemical systems have consistently failed to demonstrate robust efficacy. It remains untested whether concurrent antipsychotic medications exert pharmacodynamic interactions that ...
Carter, Cameron S, Minzenberg, Michael J, Soosman, Steffan K, Yoon, Jong H   +3 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Performance Analysis of Inverter Fed Single Phase Induction Motor Drive

ABUAD Journal of Engineering Research and Development
This paper presents performance analysis of effects of modulation index on cascaded multilevel inverter fed single phase induction motor drive using closest level control technique. The modulation index is varied to analyze its performance.
Gerald Chidozie Diyoke, Candidus Ugwuoke Eya, Patrick Ifeanyichukwu Obi, Ifeanyichukwu Kalu Onwuka   +3 more
doaj   +1 more source

Harmonic load modulation in Doherty amplifiers [PDF]

Electronics Letters, 2008
In a Doherty amplifier employing a class-B main amplifier and a class-C peaking amplifier, harmonics are normally suppressed at each amplifier. If odd harmonic currents generated by the peaking amplifier are permitted to flow into the main amplifier, the loadline of the main amplifier is shaped in such a manner as to allow a lower supply voltage to be ...
Eccleston, K.W., Smith, K.J.I,, Mann, S.I., Gough, P.T.   +3 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Receiver Multiuser Diversity Aided Multi-Stage MMSE Multiuser Detection for DS-CDMA and SDMA Systems Employing I-Q Modulation

, 2010
The so-called receiver multiuser diversity aided multistage minimum mean-square error multiuser detector (RMD/MS-MMSE MUD), which was proposed previously by the author, is investigated in the context of the direct-sequence code-division multiple-access ...
Yang, Lie-Liang
core   +1 more source

A Fault-Tolerant T-Type Multilevel Inverter Topology With Increased Overload Capability and Soft-Switching Characteristics [PDF]

, 2017
he performance of a novel three-phase four-leg fault-tolerant T-type inverter topology is introduced in this paper. This inverter topology provides a fault-tolerant solution to any open-circuit and certain short-circuit switching faults in the power ...
Demerdash, Nabeel, He, Jiangbiao, Katebi, Ramin, Wei, Lixiang, Weise, Nathan   +4 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Multidimensional Index Modulation in Wireless Communications

IEEE Access, 2018
In index modulation schemes, information bits are conveyed through indexing of transmission entities, such as antennas, subcarriers, times slots, precoders, subarrays, and radio frequency (RF) mirrors.
Bharath Shamasundar, Sandeep Bhat, Swaroop Jacob, Ananthanarayanan Chockalingam   +3 more
doaj   +1 more source